tolQ:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

TolQ

Synonyms

membrane spanning protein in TolA-TolQ-TolR complex[1], B0737[2][1], Fii[2][1], TolP[2][1], TolQ[2][1] , ECK0726, fii, JW0727, tolP, b0737

Product description

TolQ[2][3];

Component of Tol-Pal Cell Envelope Complex[2]; The Tol-Pal Cell Envelope Complex[3]; The Colicin A Import System[3]; Colicin S4 Transport System[3]

Tolerance to group A colicins and ssDNA filamentous phage; cell envelope integrity; inner membrane protein[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

PMID:10419942[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:7744737[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

PMID:8331075[7]

IDA: Inferred from Direct Assay

C

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

PMID:8331075[7]

IDA: Inferred from Direct Assay

C

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0017038

protein import

PMID:2651401[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006810

transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002898

P

Seeded from EcoCyc (v14.0)

complete

GO:0043213

bacteriocin transport

PMID:2651401[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:7744737[6]

IDA: Inferred from Direct Assay

F

with TolA

complete

GO:0008565

protein transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002898

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:10419942[5]

IDA: Inferred from Direct Assay

F

with TolR

complete

GO:0015031

protein transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0653

P

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0043213

bacteriocin transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0080

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of Tol-Pal Cell Envelope Complex

could be indirect

Protein

Subunits of The Tol-Pal Cell Envelope Complex

could be indirect

Protein

Subunits of The Colicin A Import System

could be indirect

Protein

Subunits of Colicin S4 Transport System

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 3 predicted transmembrane domains

Daley et al. (2005) [9]

Inner Membrane

PMID:8300535[10], PMID:8331075[7]

EchoLocation:tolQ


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTDMNILDLF LKASLLVKLI MLILIGFSIA SWAIIIQRTR ILNAAAREAE AFEDKFWSGI
ELSRLYQESQ GKRDNLTGSE QIFYSGFKEF VRLHRANSHA PEAVVEGASR AMRISMNREL
ENLETHIPFL GTVGSISPYI GLFGTVWGIM HAFIALGAVK QATLQMVAPG IAEALIATAI
GLFAAIPAVM AYNRLNQRVN KLELNYDNFM EEFTAILHRQ AFTVSESNKG
Length

230

Mol. Wt

25.598 kDa

pI

7.1 (calculated)

Extinction coefficient

23,950 (calc based on 5 Y, 3 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

73..211

PF01618 MotA/TolQ/ExbB proton channel family

PMID:19920124[11]

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<motif_map/>

tmhmm.php?gene=tolQ&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tolQ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128712

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948900

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002511

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABU9

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11010

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11010

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948900

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000999

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1003

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Journet, L et al. (1999) Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ. J. Bacteriol. 181 4476-84 PubMed
  6. ↑ 6.0 6.1 Derouiche, R et al. (1995) Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins. J. Biol. Chem. 270 11078-84 PubMed
  7. ↑ 7.0 7.1 7.2 Kampfenkel, K & Braun, V (1993) Membrane topologies of the TolQ and TolR proteins of Escherichia coli: inactivation of TolQ by a missense mutation in the proposed first transmembrane segment. J. Bacteriol. 175 4485-91 PubMed
  8. ↑ 8.0 8.1 Bourdineaud, JP et al. (1989) Localization and assembly into the Escherichia coli envelope of a protein required for entry of colicin A. J. Bacteriol. 171 2458-65 PubMed
  9. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  10. ↑ Vianney, A et al. (1994) Membrane topology and mutational analysis of the TolQ protein of Escherichia coli required for the uptake of macromolecules and cell envelope integrity. J. Bacteriol. 176 822-9 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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