tolC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TolC

Synonyms

transport channel[1], B3035[2][1], WeeA[2][1], Toc[2][1], RefI[2][1], MukA[2][1], MtcB[2][1], TolC[2][1] , colE1-i, ECK3026, JW5503, mtcB, mukA, refI, toc, weeA, b3035

Product description

TolC outer membrane channel[2][3]

Outer membrane factor (OMF) of tripartite efflux pumps; channel-tunnel spanning the outer membrane and periplasm; homotrimeric; ColE1 tolerance[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0042930

enterobactin transport

PMID:16166532[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:fur

P

complete

GO:0014070

response to organic cyclic substance

PMID:9473050[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005215

transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003423

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010130

P

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

PMID:6337123[7]

IDA: Inferred from Direct Assay

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

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Compartment Description Evidence Reference/Source Notes

Outer Membrane

PMID:9298646

EchoLocation:tolC

outer membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MQMKKLLPIL IGLSLSGFSS LSQAENLMQV YQQARLSNPE LRKSAADRDA AFEKINEARS
PLLPQLGLGA DYTYSNGYRD ANGINSNATS ASLQLTQSIF DMSKWRALTL QEKAAGIQDV
TYQTDQQTLI LNTATAYFNV LNAIDVLSYT QAQKEAIYRQ LDQTTQRFNV GLVAITDVQN
ARAQYDTVLA NEVTARNNLD NAVEQLRQIT GNYYPELAAL NVENFKTDKP QPVNALLKEA
EKRNLSLLQA RLSQDLAREQ IRQAQDGHLP TLDLTASTGI SDTSYSGSKT RGAAGTQYDD
SNMGQNKVGL SFSLPIYQGG MVNSQVKQAQ YNFVGASEQL ESAHRSVVQT VRSSFNNINA
SISSINAYKQ AVVSAQSSLD AMEAGYSVGT RTIVDVLDAT TTLYNAKQEL ANARYNYLIN
QLNIKSALGT LNEQDLLALN NALSKPVSTN PENVAPQTPE QNAIADGYAP DSPAPVVQQT
SARTTTSNGH NPFRN
Length

495

Mol. Wt

54 kDa

pI

5.4 (calculated)

Extinction coefficient

36,790 (calc based on 21 Y, 1 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-22

UniProt Manual:Signal Peptides

UniProt:P02930

Domain

25..209

PF02321 Outer membrane efflux protein

PMID:19920124[8]

Domain

231..427

PF02321 Outer membrane efflux protein

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tolC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111528

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947521

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009965

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P02930

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11009

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11009

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947521

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000998

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1002

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Bleuel, C et al. (2005) TolC is involved in enterobactin efflux across the outer membrane of Escherichia coli. J. Bacteriol. 187 6701-7 PubMed
  6. ↑ Aono, R et al. (1998) Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J. Bacteriol. 180 938-44 PubMed
  7. ↑ Morona, R et al. (1983) Identification and characterization of the TolC protein, an outer membrane protein from Escherichia coli. J. Bacteriol. 153 693-9 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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