sulA:Gene Product(s)

Standard name	SulA
Synonyms	SOS cell division inhibitor^[1], B0958^[2]^[1], Suf^[2]^[1], SfiA^[2]^[1], SulA^[2]^[1] , ECK0949, JW0941, sfiA, b0958
Product description	suppressor of lon; inhibits cell division and ftsZ ring formation^[2]; SOS cell division inhibitor^[3] Inhibits cell division and ftsZ ring formation; lexA regulon^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000917	barrier septum formation	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0717	P	Seeded from EcoCyc (v14.0)	complete
	GO:0005515	protein binding	PMID:8752322^[5]	IPI: Inferred from Physical Interaction		F	Seeded from EcoCyc (v14.0)	Missing: with/from
	GO:0032466	negative regulation of cytokinesis	PMID:6087326^[6]	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0005515	protein binding	PMID:8752322^[5]	IPI: Inferred from Physical Interaction	EcoliWiki:ftsZ	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006281	DNA repair	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006974	response to DNA damage stimulus	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01179	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006974	response to DNA damage stimulus	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded from EcoCyc (v14.0)	complete
	GO:0007049	cell cycle	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009276	Gram-negative-bacterium-type cell wall	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004596	C	Seeded from EcoCyc (v14.0)	complete
	GO:0009432	SOS response	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01179	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009432	SOS response	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004596	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009432	SOS response	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0742	P	Seeded from EcoCyc (v14.0)	complete
	GO:0051782	negative regulation of cell division	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01179	P	Seeded from EcoCyc (v14.0)	complete
	GO:0051782	negative regulation of cell division	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004596	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009432	SOS response	PMID:6998947^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded from EcoCyc (v14.0)	complete
	GO:0051782	negative regulation of cell division	PMID:6998947^[7]	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0006974	response to DNA damage stimulus	PMID:11967071^[8]	IEP: Inferred from Expression Pattern		P		complete
	GO:0005515	protein binding	PMID:8752322^[5]	IPI: Inferred from Physical Interaction	EcoliWiki: ftsZ	F		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	FtsZ full length	FtsZ and SulA interact directly causing SulA to block cell division	PMID:8752322^[5]	2 hybrid screen
Protein	FtsZ2		PMID:8752322^[5]	2 hybrid screen
Protein	FtsZ ring	sulA blocks formation of FtsZ ring and leads to filamentation	PMID:8432706^[9]
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</protect>

Notes

FtsZ contains a fairly strong activation domain (AD) and cannot be used as the bait in 2 hybrid screens.^[5]

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MYTSGYAHRS SSFSSAASKI ARVSTENTTA GLISEVVYRE DQPMMTQLLL LPLLQQLGQQ SRWQLWLTPQ QKLSREWVQA SGLPLTKVMQ ISQLSPCHTV ESMVRALRTG NYSVVIGWLA DDLTEEEHAE LVDAANEGNA MGFIMRPVSA SSHATRQLSG LKIHSNLYH
Length	169
Mol. Wt	18.8 kDa
pI	7.1 (calculated)
Extinction coefficient	29,450 - 29,575 (calc based on 5 Y, 4 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	2..120	PF03846 Cell division inhibitor SulA		PMID:19920124^[10]
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=sulA taxon=562,83333 </beststructure>

Models

View models at:

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</protect>

Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128925	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947335	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003244	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AFZ5	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10984	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10984	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947335	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000973	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0977	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Huang, J et al. (1996) Interaction between FtsZ and inhibitors of cell division. J. Bacteriol. 178 5080-5 PubMed
↑ Huisman, O et al. (1984) Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation. Proc. Natl. Acad. Sci. U.S.A. 81 4490-4 PubMed
↑ ^7.0 ^7.1 Huisman, O et al. (1980) Further characterization of sfiA and sfiB mutations in Escherichia coli. J. Bacteriol. 144 185-91 PubMed
↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed
↑ Bi, E & Lutkenhaus, J (1993) Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring. J. Bacteriol. 175 1118-25 PubMed
↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

sulA:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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