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Expression|

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Standard Name	qmcA
Gene Synonym(s)	ybbK, ECK0483, b0489, JW0478^[1]^[2], JW0478
Product Desc.	putative protease^[2]^[3] Multicopy suppressor of ftsH htpX double mutant; membrane-anchored with C-terminal cytoplasmic PHB domain; non-essential gene^[4]
Product Synonyms(s)	predicted protease, membrane anchored^[1], B0489^[2]^[1], YbbK^[2]^[1], QmcA^[2]^[1] , ECK0483, JW0478, ybbK, b0489
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ybbJ^[2]
Regulation/Activity
Quick Links
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Notes

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Prohibitin homology (PHB) domain. QmcA is oligomeric and interacts with ftsH. QmcA suppressor activity, but not protein synthesis, is stimulated by downstream NfeD/STOPP family gene ybbJ. QmcA expression from the chromosome is detected, but must be insufficient for suppression. QmcA is not stably complexed with FtsH, but they do physically interact.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	qmcA
Mnemonic	Quality control-related Membrane Complex
Synonyms	ybbK, ECK0483, b0489, JW0478^[1]^[2], JW0478
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	11.08 minutes	MG1655: 514997..514080 <gbrowseImage> name=NC_000913:514080..514997 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 487024..487941 <gbrowseImage> name=NC_012967:487024..487941 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 416839..417756 <gbrowseImage> name=NC_012759:416839..417756 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 514997..514080 <gbrowseImage> name=NC_007779:514080..514997 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 454328..453411 <gbrowseImage> name=NC_010473:453411..454328 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔqmcA772::kan					PMID:16738554	CGSC:106294
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource

Resource Type

Source

Notes/Reference

Plasmid clone

Shigen

PMID:16769691

Status:

Primer 1:

Primer 2:

7C12

Kohara Phage

Genobase

PMID:3038334

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6265	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13258	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002873	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947257	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3046	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0001697	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YbbK
Synonyms	predicted protease, membrane anchored^[1], B0489^[2]^[1], YbbK^[2]^[1], QmcA^[2]^[1] , ECK0483, JW0478, ybbK, b0489
Product description	putative protease^[2]^[3] Multicopy suppressor of ftsH htpX double mutant; membrane-anchored with C-terminal cytoplasmic PHB domain; non-essential gene^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001972	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9904	C	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	cydC	PMID:16606699	Experiment(s):EBI-1136881
Protein	aceF	PMID:16606699	Experiment(s):EBI-1136881
Protein	ydfG	PMID:19402753	LCMS(ID Probability):99.6
Protein	rpsN	PMID:19402753	LCMS(ID Probability):99.6
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
plasma membrane
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLIFIPILIF VALVIVGAGV KIVPQGYQWT VERFGRYTKT LQPGLSLVVP FMDRIGRKIN MMEQVLDIPS QEVISKDNAN VTIDAVCFIQ VIDAPRAAYE VSNLELAIIN LTMTNIRTVL GSMELDEMLS QRDSINSRLL RIVDEATNPW GIKVTRIEIR DVRPPAELIS SMNAQMKAER TKRAYILEAE GIRQAEILKA EGEKQSQILK AEGERQSAFL QAEARERSAE AEARATKMVS EAIASGDIQA VNYFVAQKYT EALQQIGSSS NSKVVMMPLE ASSLMGSIAG IAELVKDSAN KRTQP
Length	305
Mol. Wt	33.743 kDa
pI	5.4 (calculated)
Extinction coefficient	19,940 - 20,065 (calc based on 6 Y, 2 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	21..204	PF01145 SPFH domain / Band 7 family		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=qmcA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128473	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947257	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0001697	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AA53	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6265	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13258	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947257	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002873	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3046	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	178	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	150	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	151	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ybbJ
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:514977..515017 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0489 (EcoliWiki Page)	NCBI GEO profiles for qmcA
microarray	GenExpDB:b0489 (EcoliWiki Page)	Summary of data for qmcA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to qmcA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6265	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3046	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0489
EcoGene	EcoGene:EG13258	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002873	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0001697	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000018661 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Apis mellifera	ENSAPMP00000023312 (score: 1.000; bootstrap: 100%) ENSAPMP00000004607 (score: 0.532)	From Inparanoid:20070104
Arabidopsis thaliana	AT4G27585 (score: 1.000; bootstrap: 99%) AT5G54100 (score: 0.549)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000015136 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00042595 (score: 1.000; bootstrap: 88%)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00006061 (score: 1.000; bootstrap: 95%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000002960 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000019012 (score: 1.000; bootstrap: 93%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-040426-1139 (score: 1.000; bootstrap: 98%) ZDB-CDNA-040425-2071 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0201908 (score: 1.000; bootstrap: 79%)	From Inparanoid:20070104
Drosophila melanogaster	FBgn0034936 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Drosophila pseudoobscura	GA20495-PA (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000034251 (score: 1.000; bootstrap: 98%) ENSGALP00000027477 (score: 0.599) ENSGALP00000006610 (score: 0.363)	From Inparanoid:20070104
Homo sapiens	ENSP00000348886 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000015573 (score: 1.000; bootstrap: 97%)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000009598 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Mus musculus	MGI:1913842 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Oryza gramene	Q7EZD2 (score: 1.000; bootstrap: 99%) Q9M585 (score: 0.511)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000041700 (score: 1.000; bootstrap: 97%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000013151 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPBC16G57c (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000163308 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00003655001 (score: 1.000; bootstrap: 97%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000034943 (score: 1.000; bootstrap: 100%) ENSXETP00000012854 (score: 0.465) ENSXETP00000050207 (score: 0.283) ENSXETP00000042903 (score: 0.152)	From Inparanoid:20070104
Shigella flexneri	YBBK	From SHIGELLACYC
E. coli O157	YBBK	From ECOO157CYC
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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01145 SPFH domain / Band 7 family
Panther (EcoliWiki Page)	PTHR10264:SF27
Superfamily (EcoliWiki Page)	SUPERFAMILY:117892
EcoCyc	EcoCyc:G6265	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13258	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002873	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3046	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0001697	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.

qmcA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to qmcA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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