proC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ProC

Synonyms

pyrroline-5-carboxylate reductase, NAD(P)-binding[1], B0386[2][1], ProC[2][1] , ECK0381, JW0377, pro, Pro2, b0386

Product description

ProC[2][3];

Component of pyrroline-5-carboxylate-reductase[2][3]

Pyrroline-5-carboxylate reductase, proline biosynthesis[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004735

pyrroline-5-carboxylate reductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000304

F

Seeded from EcoCyc (v14.0)

complete

GO:0004735

pyrroline-5-carboxylate reductase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.5.1.2

F

Seeded from EcoCyc (v14.0)

complete

GO:0004735

pyrroline-5-carboxylate reductase activity

PMID:12133[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0004735

pyrroline-5-carboxylate reductase activity

PMID:6296787[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000304

P

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0641

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

P

Seeded from EcoCyc (v14.0)

complete

GO:0008652

cellular amino acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0028

P

Seeded from EcoCyc (v14.0)

complete

GO:0050661

NADP or NADPH binding

PMID:6296787[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000304

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of pyrroline-5-carboxylate-reductase

could be indirect

Protein

ydiA

PMID:16606699[7]

Experiment(s):EBI-1136420

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1136420

Protein

rpsP

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplK

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplJ

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplE

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rraB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gapA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gadB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsH

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

eno

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

tufB

PMID:19402753[8]

MALDI(Z-score):21.691492

Protein

yfiD

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

pflB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

ahpC

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplX

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

hupB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

dnaN

PMID:19402753[8]

LCMS(ID Probability):99.6 MALDI(Z-score):36.383184

Protein

rpsJ

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gyrA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

tig

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

yebC

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

parC

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

dps

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

mdh

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

frdA

PMID:19402753[8]

LCMS(ID Probability):98.5

Protein

ppk

PMID:19402753[8]

LCMS(ID Probability):99.4

Protein

fabB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

dksA

PMID:19402753[8]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MEKKIGFIGC GNMGKAILGG LIASGQVLPG QIWVYTPSPD KVAALHDQFG INAAESAQEV
AQIADIIFAA VKPGIMIKVL SEITSSLNKD SLVVSIAAGV TLDQLARALG HDRKIIRAMP
NTPALVNAGM TSVTPNALVT PEDTADVLNI FRCFGEAEVI AEPMIHPVVG VSGSSPAYVF
MFIEAMADAA VLGGMPRAQA YKFAAQAVMG SAKMVLETGE HPGALKDMVC SPGGTTIEAV
RVLEEKGFRA AVIEAMTKCM EKSEKLSKS
Length

269

Mol. Wt

28.144 kDa

pI

5.7 (calculated)

Extinction coefficient

9,970 - 10,470 (calc based on 3 Y, 1 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

4..99

PF03807 NADP oxidoreductase coenzyme F420-dependent

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=proC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128371

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945034

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001338

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A9L8

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10769

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10769

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945034

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000760

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0762

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Rossi, JJ et al. (1977) Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli. J. Bacteriol. 129 108-14 PubMed
  6. ↑ 6.0 6.1 Deutch, AH et al. (1982) Escherichia coli delta 1-pyrroline-5-carboxylate reductase: gene sequence, protein overproduction and purification. Nucleic Acids Res. 10 7701-14 PubMed
  7. ↑ 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 8.22 8.23 8.24 8.25 8.26 8.27 8.28 8.29 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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