nupG:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

NupG

Synonyms

nucleoside transporter[1], B2964[2][1], NupG[2][1] , ECK2959, JW2932, b2964

Product description

NupG nucleoside MFS transporter[2][3]

Nucleoside transporter[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005337

nucleoside transmembrane transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004740

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0015858

nucleoside transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004740

P

Seeded from EcoCyc (v14.0)

complete

GO:0005887

integral to plasma membrane

PMID:15513740[5]

IDA: Inferred from Direct Assay

C

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0015864

pyrimidine nucleoside transport

PMID:15513740[5]

IDA: Inferred from Direct Assay

P

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004740

C

Seeded from EcoCyc (v14.0)

complete

GO:0015862

uridine transport

PMID:15513740[5]

IDA: Inferred from Direct Assay

P

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0015213

uridine transmembrane transporter activity

PMID:15513740[5]

IDA: Inferred from Direct Assay

F

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0015214

pyrimidine nucleoside transmembrane transporter activity

PMID:15513740[5]

IDA: Inferred from Direct Assay

F

complete

GO:0015213

uridine transmembrane transporter activity

PMID:374403[6]

IMP: Inferred from Mutant Phenotype

F

Fig. 3

complete

GO:0015212

cytidine transmembrane transporter activity

PMID:374403[6]

IMP: Inferred from Mutant Phenotype

F

Fig. 3

complete

GO:0032238

adenosine transport

PMID:374403[6]

IMP: Inferred from Mutant Phenotype

P

Fig. 3

complete

GO:0015860

purine nucleoside transmembrane transport

PMID:374403[6]

IMP: Inferred from Mutant Phenotype

P

Fig. 3, both guanosine and adenosine are transported

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 12 predicted transmembrane domains

Daley et al. (2005) [7]

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MCFFKHSSAS RCEEINMNLK LQLKILSFLQ FCLWGSWLTT LGSYMFVTLK FDGASIGAVY
SSLGIAAVFM PALLGIVADK WLSAKWVYAI CHTIGAITLF MAAQVTTPEA MFLVILINSF
AYMPTLGLIN TISYYRLQNA GMDIVTDFPP IRIWGTIGFI MAMWVVSLSG FELSHMQLYI
GAALSAILVL FTLTLPHIPV AKQQANQSWT TLLGLDAFAL FKNKRMAIFF IFSMLLGAEL
QITNMFGNTF LHSFDKDPMF ASSFIVQHAS IIMSISQISE TLFILTIPFF LSRYGIKNVM
MISIVAWILR FALFAYGDPT PFGTVLLVLS MIVYGCAFDF FNISGSVFVE KEVSPAIRAS
AQGMFLMMTN GFGCILGGIV SGKVVEMYTQ NGITDWQTVW LIFAGYSVVL AFAFMAMFKY
KHVRVPTGTQ TVSH
Length

434

Mol. Wt

48.262 kDa

pI

8.6 (calculated)

Extinction coefficient

74,370 - 75,120 (calc based on 13 Y, 10 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..407

PF03825 Nucleoside H+ symporter

PMID:19920124[8]

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tmhmm.php?gene=nupG&show=pic&.jpg
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=nupG taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111521

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946282

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009728

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AFF4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10664

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10664

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946282

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000657

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0658

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Xie, H et al. () Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family. Mol. Membr. Biol. 21 323-36 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Munch-Petersen, A et al. (1979) Nucleoside transport in cells and membrane vesicles from Escherichia coli K12. J. Biol. Chem. 254 3730-7 PubMed
  7. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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