mltA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MltA

Synonyms

membrane-bound lytic murein transglycosylase A[1], B2813[2][1], YgdM[2][1], Mlt[2][1], MltA[2][1] , ECK2809, JW2784, mlt, ygdM, b2813

Product description

membrane-bound lytic murein transglycosylase A[2][3]

Membrane-bound lytic transglycosylase A, murein hydrolase; periplasmic OM-attached lipoprotein[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005300

F

Seeded from EcoCyc (v14.0)

complete

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010611

F

Seeded from EcoCyc (v14.0)

complete

GO:0005887

integral to plasma membrane

PMID:8288527[5]

IDA: Inferred from Direct Assay

C

complete

GO:0009254

peptidoglycan turnover

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010611

P

Seeded from EcoCyc (v14.0)

complete

GO:0008933

lytic transglycosylase activity

PMID:8288527[5]

IDA: Inferred from Direct Assay

F

complete

GO:0009279

cell outer membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0016837

carbon-oxygen lyase activity, acting on polysaccharides

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.2.2

F

Seeded from EcoCyc (v14.0)

complete

GO:0019867

outer membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010611

C

Seeded from EcoCyc (v14.0)

complete

GO:0031225

anchored to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9901

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

proV

PMID:16606699[6]

Experiment(s):EBI-1144046
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Outer membrane

PMID:15174130

EchoLocation:mltA


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKGRWVKYLL MGTVVAMLAA CSSKPTDRGQ QYKDGKFTQP FSLVNQPDAV GAPINAGDFA
EQINHIRNSS PRLYGNQSNV YNAVQEWLRA GGDTRNMRQF GIDAWQMEGA DNYGNVQFTG
YYTPVIQARH TRQGEFQYPI YRMPPKRGRL PSRAEIYAGA LSDKYILAYS NSLMDNFIMD
VQGSGYIDFG DGSPLNFFSY AGKNGHAYRS IGKVLIDRGE VKKEDMSMQA IRHWGETHSE
AEVRELLEQN PSFVFFKPQS FAPVKGASAV PLVGRASVAS DRSIIPPGTT LLAEVPLLDN
NGKFNGQYEL RLMVALDVGG AIKGQHFDIY QGIGPEAGHR AGWYNHYGRV WVLKTAPGAG
NVFSG
Length

365

Mol. Wt

40.41 kDa

pI

9.4 (calculated)

Extinction coefficient

61,310 - 61,435 (calc based on 19 Y, 6 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-20

UniProt Manual:Signal Peptides

UniProt:P0A935

Domain

125..257

PF03562 MltA specific insert domain

PMID:19920124[7]

Domain

276..354

PF06725 3D domain

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mltA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130720

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944964

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009228

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A935

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7457

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13085

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944964

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004020

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2894

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Ursinus, A & Höltje, JV (1994) Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli. J. Bacteriol. 176 338-43 PubMed
  6. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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