lpxB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LpxB

Synonyms

tetraacyldisaccharide-1-P synthase[1], B0182[2][1], PgsB[2][1], LpxB[2][1] , ECK0181, JW0177, pgsB, b0182

Product description

LpxB[2][3];

Component of lipid A disaccharide synthase[3]

Lipid A disaccharide synthase[4]

EC number (for enzymes)

2.4.1.182[1]

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008915

lipid-A-disaccharide synthase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00392

F

Seeded from EcoCyc (v14.0)

complete

GO:0008915

lipid-A-disaccharide synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003835

F

Seeded from EcoCyc (v14.0)

complete

GO:0008915

lipid-A-disaccharide synthase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.4.1.182

F

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00392

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003835

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441

P

Seeded from EcoCyc (v14.0)

complete

GO:0019897

extrinsic to plasma membrane

PMID:19883124[5]

IDA: Inferred from Direct Assay

C

complete

GO:0005543

phospholipid binding

PMID:19883124[5]

IDA: Inferred from Direct Assay

F

complete

GO:0008915

lipid-A-disaccharide synthase activity

PMID:6370995[6]

IDA: Inferred from Direct Assay

F

complete

GO:0009245

lipid A biosynthetic process

PMID:6370995[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009245

lipid A biosynthetic process

PMID:3531165[7]

IEP: Inferred from Expression Pattern

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of lipid A disaccharide synthase

could be indirect

Protein

tufA

PMID:15690043[8]

Experiment(s):EBI-886035, EBI-892581

Protein

sdhA

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

mreB

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

dnaJ

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

ppsA

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

rplJ

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

dadA

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

glpD

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

uspG

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

prs

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

groL

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

fur

PMID:16606699[9]

Experiment(s):EBI-1135833

Protein

uppP

PMID:15690043[8]

Experiment(s):EBI-892581

Protein

rplM

PMID:15690043[8]

Experiment(s):EBI-892581

Protein

rplS

PMID:15690043[8]

Experiment(s):EBI-892581

Protein

rpsB

PMID:15690043[8]

Experiment(s):EBI-892581

Protein

torC

PMID:15690043[8]

Experiment(s):EBI-892581

Protein

tufB

PMID:19402753[10]

MALDI(Z-score):19.578618

Protein

rpsD

PMID:19402753[10]

MALDI(Z-score):30.803055

Protein

torC

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

bacA

PMID:19402753[10]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTEQRPLTIA LVAGETSGDI LGAGLIRALK EHVPNARFVG VAGPRMQAEG CEAWYEMEEL
AVMGIVEVLG RLRRLLHIRA DLTKRFGELK PDVFVGIDAP DFNITLEGNL KKQGIKTIHY
VSPSVWAWRQ KRVFKIGRAT DLVLAFLPFE KAFYDKYNVP CRFIGHTMAD AMPLDPDKNA
ARDVLGIPHD AHCLALLPGS RGAEVEMLSA DFLKTAQLLR QTYPDLEIVV PLVNAKRREQ
FERIKAEVAP DLSVHLLDGM GREAMVASDA ALLASGTAAL ECMLAKCPMV VGYRMKPFTF
WLAKRLVKTD YVSLPNLLAG RELVKELLQE ECEPQKLAAA LLPLLANGKT SHAMHDTFRE
LHQQIRCNAD EQAAQAVLEL AQ
Length

382

Mol. Wt

42.382 kDa

pI

7.0 (calculated)

Extinction coefficient

32,430 - 33,305 (calc based on 7 Y, 4 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

9..377

PF02684 Lipid-A-disaccharide synthetase

PMID:19920124[11]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lpxB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128175

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944838

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000620

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P10441

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10546

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10546

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944838

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000539

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0541

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Metzger, LE 4th & Raetz, CR (2009) Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein. Biochemistry 48 11559-71 PubMed
  6. ↑ 6.0 6.1 Ray, BL et al. (1984) The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli. J. Biol. Chem. 259 4852-9 PubMed
  7. ↑ Crowell, DN et al. (1986) Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coli. J. Bacteriol. 168 152-9 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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