Category:Complex:lipid A disaccharide synthase
About
Description (originally from EcoCyc[1]) lipid A disaccharide synthase
Comments (originally from EcoCyc[1]) Lipid A disaccharide synthase (LpxB) catalyzes the fifth step in lipid A biosynthesis.
LpxB catalyzes the condensation of 2,3-bis(3-hydroxymyristoyl)-β-D-glucosaminyl 1-phosphate and UDP-2,3-bis(3-hydroxymyristoyl)glucosamine (lipid X) to form lipid A disaccharide [2][3][4][5][4][6][7][8][9].
References
- ↑ 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Ray, BL et al. (1984) The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli. J. Biol. Chem. 259 4852-9 PubMed
- ↑ Crowell, DN et al. (1986) Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coli. J. Bacteriol. 168 152-9 PubMed
- ↑ 4.0 4.1 Radika, K & Raetz, CR (1988) Purification and properties of lipid A disaccharide synthase of Escherichia coli. J. Biol. Chem. 263 14859-67 PubMed
- ↑ Babinski, KJ et al. (2002) Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene. J. Biol. Chem. 277 25947-56 PubMed
- ↑ Milla, ME & Raetz, CR (1996) Association of lipid A disaccharide synthase with aerobic glycerol-3-phosphate dehydrogenase in extracts of Escherichia coli. Biochim. Biophys. Acta 1304 245-53 PubMed
- ↑ Nishijima, M & Raetz, CR (1979) Membrane lipid biogenesis in Escherichia coli: identification of genetic loci for phosphatidylglycerophosphate synthetase and construction of mutants lacking phosphatidylglycerol. J. Biol. Chem. 254 7837-44 PubMed
- ↑ Nishijima, M et al. (1981) Two interacting mutations causing temperature-sensitive phosphatidylglycerol synthesis in Escherichia coli membranes. J. Bacteriol. 145 113-21 PubMed
- ↑ Bulawa, CE & Raetz, CR (1984) The biosynthesis of gram-negative endotoxin. Identification and function of UDP-2,3-diacylglucosamine in Escherichia coli. J. Biol. Chem. 259 4846-51 PubMed
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