hrpA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HrpA

Synonyms

ATP-dependent helicase[1], B1413[2][1], HrpA[2][1] , ECK1406, JW5905, b1413

Product description

predicted ATP-dependent helicase, involved in mRNA processing[2][3]

RNA helicase-like; similarity to eukaryotic DEAH family[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004386

helicase activity

PMID:15186427[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0009451

RNA modification

PMID:15186427[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded from EcoCyc (v14.0)

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011545

F

Seeded from EcoCyc (v14.0)

complete

GO:0004386

helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded from EcoCyc (v14.0)

complete

GO:0004386

helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007502

F

Seeded from EcoCyc (v14.0)

complete

GO:0004386

helicase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0347

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010222

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011545

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0008026

ATP-dependent helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010222

F

Seeded from EcoCyc (v14.0)

complete

GO:0008026

ATP-dependent helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011545

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0017111

nucleoside-triphosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

aceE

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

aceF

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

lpdA

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rplI

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsA

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsB

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsC

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsE

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsG

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsM

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

rpsS

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

tufA

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

yfiF

PMID:15690043[6]

Experiment(s):EBI-884859

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):19.500516

Protein

rpsC

PMID:19402753[7]

MALDI(Z-score):31.200902

Protein

rpsA

PMID:19402753[7]

MALDI(Z-score):25.115542

Protein

rplA

PMID:19402753[7]

MALDI(Z-score):24.337429

Protein

yfiF

PMID:19402753[7]

MALDI(Z-score):37.301991

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLRDRLRFSR RLHGVKKVKN PDAQQAIFQE MAKEIDQAAG KVLLREAARP EITYPDNLPV
SQKKQDILEA IRDHQVVIVA GETGSGKTTQ LPKICMELGR GIKGLIGHTQ PRRLAARTVA
NRIAEELKTE PGGCIGYKVR FSDHVSDNTM VKLMTDGILL AEIQQDRLLM QYDTIIIDEA
HERSLNIDFL LGYLKELLPR RPDLKIIITS ATIDPERFSR HFNNAPIIEV SGRTYPVEVR
YRPIVEEADD TERDQLQAIF DAVDELSQES HGDILIFMSG EREIRDTADA LNKLNLRHTE
ILPLYARLSN SEQNRVFQSH SGRRIVLATN VAETSLTVPG IKYVIDPGTA RISRYSYRTK
VQRLPIEPIS QASANQRKGR CGRVSEGICI RLYSEDDFLS RPEFTDPEIL RTNLASVILQ
MTALGLGDIA AFPFVEAPDK RNIQDGVRLL EELGAITTDE QASAYKLTPL GRQLSQLPVD
PRLARMVLEA QKHGCVREAM IITSALSIQD PRERPMDKQQ ASDEKHRRFH DKESDFLAFV
NLWNYLGEQQ KALSSNAFRR LCRTDYLNYL RVREWQDIYT QLRQVVKELG IPVNSEPAEY
REIHIALLTG LLSHIGMKDA DKQEYTGARN ARFSIFPGSG LFKKPPKWVM VAELVETSRL
WGRIAARIDP EWVEPVAQHL IKRTYSEPHW ERAQGAVMAT EKVTVYGLPI VAARKVNYSQ
IDPALCRELF IRHALVEGDW QTRHAFFREN LKLRAEVEEL EHKSRRRDIL VDDETLFEFY
DQRISHDVIS ARHFDSWWKK VSRETPDLLN FEKSMLIKEG AEKISKLDYP NFWHQGNLKL
RLSYQFEPGA DADGVTVHIP LPLLNQVEES GFEWQIPGLR RELVIALIKS LPKPVRRNFV
PAPNYAEAFL GRVKPLELPL LDSLERELRR MTGVTVDRED WHWDQVPDHL KITFRVVDDK
NKKLKEGRSL QDLKDALKGK VQETLSAVAD DGIEQSGLHI WSFGQLPESY EQKRGNYKVK
AWPALVDERD SVAIKLFDNP LEQKQAMWNG LRRLLLLNIP SPIKYLHEKL PNKAKLGLYF
NPYGKVLELI DDCISCGVDK LIDANGGPVW TEEGFAALHE KVRAELNDTV VDIAKQVEQI
LTAVFNINKR LKGRVDMTMA LGLSDIKAQM GGLVYRGFVT GNGFKRLGDT LRYLQAIEKR
LEKLAVDPHR DRAQMLKVEN VQQAWQQWIN KLPPARREDE DVKEIRWMIE ELRVSYFAQQ
LGTPYPISDK RILQAMEQIS G
Length

1,281

Mol. Wt

146.798 kDa

pI

8.0 (calculated)

Extinction coefficient

160,660 - 161,785 (calc based on 34 Y, 20 W, and 9 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

80..239

PF00270 DEAD/DEAH box helicase

PMID:19920124[8]

Domain

464..559

PF04408 Helicase associated domain (HA2)

PMID:19920124[8]

Domain

311..404

PF00271 Helicase conserved C-terminal domain

PMID:19920124[8]

Domain

599..699

PF07717 Domain of unknown function (DUF1605)

PMID:19920124[8]

Domain

711..1298

PF11898 Domain of unknown function (DUF3418)

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hrpA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:145698255

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948444

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004718

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P43329

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6732

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12936

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948444

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003325

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2772

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Koo, JT et al. (2004) HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli. Mol. Microbiol. 52 1813-26 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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