hns:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Hns

Synonyms

global DNA-binding transcriptional dual regulator H-NS[1], B1237[2][1], Irk[2][1], MsyA[2][1], PilG[2][1], TopS[2][1], TopX[2][1], VirR[2][1], Drs[2][1], Drc[2][1], Cur[2][1], Hns[2][1], DrdX[2][1], BglY[2][1], HnsA[2][1], DNA-binding protein HLP-II (HU, BH2, HD, NS); pleiotropic regulator[2][1], OsmZ[2][1], DNA-binding protein HLP-II (HU, BH2, HD, NS)[3][1] , B1, bglY, cur, drc, drdX, drs, ECK1232, fimG, H1, hnsA, irk, JW1225, msyA, osmZ, pilG, topS, topX, verA, virR, b1237

Product description

H-NS transcriptional dual regulator[2][3]

DNA-binding global regulator H-NS; diverse mutant phenotypes affecting transcription, transposition, inversion, cryptic-gene expression; involved in chromosome organization; preferentially binds bent DNA; has N-terminal dimerization domain[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

C

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0003681

bent DNA binding

PMID:10551881[6]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ssb

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

ymfG

PMID:16606699[8]

Experiment(s):EBI-1139271

Protein

stpA

PMID:16606699[8]

Experiment(s):EBI-1139271

Protein

sxy

PMID:16606699[8]

Experiment(s):EBI-1139271

Protein

prs

PMID:16606699[8]

Experiment(s):EBI-1139271

Protein

rplN

PMID:16606699[8]

Experiment(s):EBI-1139271

Protein

ruvC

PMID:16606699[8]

Experiment(s):EBI-1139271

Protein

aceE

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

ynbC

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

malP

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

malQ

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

rpoB

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

rpoC

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-890481, EBI-895331

Protein

secA

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

tig

PMID:15690043[7]

Experiment(s):EBI-890481

Protein

cnu

PMID:15690043[7]

Experiment(s):EBI-895331

Protein

hupA

PMID:15690043[7]

Experiment(s):EBI-895331

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-895331

Protein

rplX

PMID:15690043[7]

Experiment(s):EBI-895331

Protein

stpA

PMID:15690043[7]

Experiment(s):EBI-895331

Protein

tig

PMID:19402753[9]

LCMS(ID Probability):97.9 MALDI(Z-score):36.434009

Protein

ssb

PMID:19402753[9]

MALDI(Z-score):29.456422

Protein

rplX

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

stpA

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

cnu

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

HF-1

H-NS acts upstream or at the same level that HF-1 does; H-NS influences the expression or activity of HF-1 leading to affects in rpoStranslation

PMID:8654929[10]

there is no change in rpoS translation when there is an hns mutation when in and hfq mutant

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSEALKILNN IRTLRAQARE CTLETLEEML EKLEVVVNER REEESAAAAE VEERTRKLQQ
YREMLIADGI DPNELLNSLA AVKSGTKAKR AQRPAKYSYV DENGETKTWT GQGRTPAVIK
KAMDEQGKSL DDFLIKQ
Length

137

Mol. Wt

15.539 kDa

pI

5.3 (calculated)

Extinction coefficient

9,970 - 10,095 (calc based on 3 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0ACF8

Domain

24..130

PF00816 H-NS histone family

PMID:19920124[11]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hns taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129198

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945829

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004152

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ACF8

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10457

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10457

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945829

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000450

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0452

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ Muffler, A et al. (1996) The RNA-binding protein HF-I, known as a host factor for phage Qbeta RNA replication, is essential for rpoS translation in Escherichia coli. Genes Dev. 10 1143-51 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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