hlyE:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
HlyE |
|---|---|
| Synonyms |
hemolysin E[1], B1182[2][1], YcgD[2][1], Hpr[2][1], SheA[2][1], ClyA[2][1], HlyE[2][1] , clyA, ECK1170, hpr, JW5181, sheA, ycgD, b1182 |
| Product description |
Latent secreted hemolysin E; regulated by SlyA, Fnr and HN-S[4] |
| EC number (for enzymes) |
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| edit table |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0009405 |
pathogenesis |
IDA: Inferred from Direct Assay |
P |
Purified HlyE and E. coli cells expressing HlyE were shown to be cytotoxic to fresh or cultured human and murine monocytes/macrophages. |
complete | |||
| GO:0044532 |
modulation of apoptotic process in other organism |
IDA: Inferred from Direct Assay |
P |
Purified HlyE and E. coli cells expressing HlyE were shown to be cytotoxic to fresh or cultured human and murine monocytes/macrophages. |
complete | |||
| GO:0005576 |
extracellular region |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009405 |
pathogenesis |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-9904 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0019835 |
cytolysis |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0019836 |
hemolysis by symbiont of host erythrocytes |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0042597 |
periplasmic space |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0042597 |
periplasmic space |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0200 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
galF |
MALDI(Z-score):31.507337 | ||
| edit table |
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
|
periplasm |
| |||
| edit table |
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MIMTEIVADK TVEVVKNAIE TADGALDLYN KYLDQVIPWQ TFDETIKELS RFKQEYSQAA SVLVGDIKTL LMDSQDKYFE ATQTVYEWCG VATQLLAAYI LLFDEYNEKK ASAQKDILIK VLDDGITKLN EAQKSLLVSS QSFNNASGKL LALDSQLTND FSEKSSYFQS QVDKIRKEAY AGAAAGVVAG PFGLIISYSI AAGVVEGKLI PELKNKLKSV QNFFTTLSNT VKQANKDIDA AKLKLTTEIA AIGEIKTETE TTRFYVDYDD LMLSLLKEAA KKMINTCNEY QKRHGKKTLF EVPEV |
| Length |
305 |
| Mol. Wt |
34.003 kDa |
| pI |
4.9 (calculated) |
| Extinction coefficient |
30,370 - 30,620 (calc based on 13 Y, 2 W, and 2 C residues) |
| edit table |
Domains/Motifs/Modification Sites
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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
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Structure
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Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Lai, XH et al. (2000) Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages. Infect. Immun. 68 4363-7 PubMed
- ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
- ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0009405 ! pathogenesis
- GO:0044532 ! modulation of apoptotic process in other organism
- GO:0005576 ! extracellular region
- GO:0016020 ! membrane
- GO:0016021 ! integral component of membrane
- GO:0019835 ! cytolysis
- GO:0019836 ! hemolysis by symbiont of host erythrocytes
- GO:0042597 ! periplasmic space
- Proteins
- Location:periplasm
- Products with structures in PDB
- Pfam:PF06109 ! Haemolysin E (HlyE)
