fabA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabA

Synonyms

beta-hydroxydecanoyl thioester dehydrase[1], B0954[2][1], FabA[2][1] , ECK0945, JW0937, b0954

Product description

FabA[2][3];

Component of FABA-CPLX[2]

3R-3-hydroxydecanoyl acyl carrier protein (ACP) dehydratase; also called beta-hydroxydecanoylthioester dehydrase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000794

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00405

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010083

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00405

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010083

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

PMID:19679654[5]

IGI: Inferred from Genetic Interaction

UniProtKB:Q39473


P

complete

GO:0006633

fatty acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

PMID:19679654[5]

IGI: Inferred from Genetic Interaction

UniProtKB:Q39473 EcoliWiki:fadD


P

complete

GO:0008610

lipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc (v14.0)

complete

GO:0008693

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00405

F

Seeded from EcoCyc (v14.0)

complete

GO:0008693

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010083

F

Seeded from EcoCyc (v14.0)

complete

GO:0008693

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.2.1.60

F

Seeded from EcoCyc (v14.0)

complete

GO:0009058

biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000794

P

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of FABA-CPLX

could be indirect

Protein

accA

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

ves

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

deaD

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

ffh

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

metK

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rplA

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rplB

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rplS

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rpsA

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rpsB

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rpsE

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rpsG

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rpsI

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

rpsM

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

tig

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

tufA

PMID:15690043[6]

Experiment(s):EBI-887293

Protein

hupA

PMID:15690043[6]

Experiment(s):EBI-893249

Protein

rpsR

PMID:15690043[6]

Experiment(s):EBI-893249

Protein

sucB

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

yfdS

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

ygeY

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

rpoC

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

lacZ

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

ybfC

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

ilvA

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

rpoB

PMID:16606699[7]

Experiment(s):EBI-1138471

Protein

rpsR

PMID:19402753[8]

LCMS(ID Probability):99.4

Protein

rplU

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsC

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

pflB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplK

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gapA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gadB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplB

PMID:19402753[8]

MALDI(Z-score):26.679973

Protein

rpsM

PMID:19402753[8]

MALDI(Z-score):27.146181

Protein

rpsF

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpmB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

eno

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

ahpC

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsA

PMID:19402753[8]

MALDI(Z-score):27.129490

Protein

groS

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

metK

PMID:19402753[8]

MALDI(Z-score):30.362662

Protein

rplA

PMID:19402753[8]

MALDI(Z-score):28.482664

Protein

pgk

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

tig

PMID:19402753[8]

MALDI(Z-score):20.265244

Protein

ffh

PMID:19402753[8]

MALDI(Z-score):30.108857

Protein

fabB

PMID:19402753[8]

MALDI(Z-score):24.965065

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MVDKRESYTK EDLLASGRGE LFGAKGPQLP APNMLMMDRV VKMTETGGNF DKGYVEAELD
INPDLWFFGC HFIGDPVMPG CLGLDAMWQL VGFYLGWLGG EGKGRALGVG EVKFTGQVLP
TAKKVTYRIH FKRIVNRRLI MGLADGEVLV DGRLIYTASD LKVGLFQDTS AF
Length

172

Mol. Wt

18.969 kDa

pI

6.5 (calculated)

Extinction coefficient

23,950 - 24,200 (calc based on 5 Y, 3 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A6Q3

Domain

29..159

PF07977 FabA-like domain

PMID:19920124[9]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fabA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128921

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945568

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003229

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6Q3

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10273

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10273

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945568

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000267

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0269

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Feng, Y & Cronan, JE (2009) Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB. J. Biol. Chem. 284 29526-35 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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