dxs:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Dxs

Synonyms

1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring[1], B0420[2][1], YajP[2][1], Dxs[2][1] , ECK0414, JW0410, yajP, b0420

Product description

Dxs[2][3];

Component of 1-deoxyxylulose-5-phosphate synthase[3]

DXP synthase; DXP is precursor to isoprenoids, thiamin, pyridoxol[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0008299

isoprenoid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0414

P

Seeded from EcoCyc (v14.0)

complete

GO:0008661

1-deoxy-D-xylulose-5-phosphate synthase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00315

F

Seeded from EcoCyc (v14.0)

complete

GO:0008661

1-deoxy-D-xylulose-5-phosphate synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005477

F

Seeded from EcoCyc (v14.0)

complete

GO:0008661

1-deoxy-D-xylulose-5-phosphate synthase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.2.1.7

F

Seeded from EcoCyc (v14.0)

complete

GO:0009228

thiamin biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00315

P

Seeded from EcoCyc (v14.0)

complete

GO:0009228

thiamin biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0784

P

Seeded from EcoCyc (v14.0)

complete

GO:0016114

terpenoid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00315

P

Seeded from EcoCyc (v14.0)

complete

GO:0016114

terpenoid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005477

P

Seeded from EcoCyc (v14.0)

complete

GO:0016624

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

F

Seeded from EcoCyc (v14.0)

complete

GO:0030145

manganese ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0464

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of 1-deoxyxylulose-5-phosphate synthase

could be indirect

Protein

aceE

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

adhE

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

clpA

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

lon

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

mreB

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

pstB

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

rho

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

yjgL

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

yqeI

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

recA

PMID:15690043[5]

Experiment(s):EBI-880291

Protein

fdnG

PMID:16606699[6]

Experiment(s):EBI-1136539

Protein

appY

PMID:16606699[6]

Experiment(s):EBI-1136539

Protein

gltB

PMID:16606699[6]

Experiment(s):EBI-1136539

Protein

tatE

PMID:16606699[6]

Experiment(s):EBI-1136539

Protein

lacZ

PMID:16606699[6]

Experiment(s):EBI-1136539

Protein

cspA

PMID:16606699[6]

Experiment(s):EBI-1136539

Protein

recA

PMID:19402753[7]

MALDI(Z-score):20.093806

Protein

rho

PMID:19402753[7]

MALDI(Z-score):36.857007

Protein

clpA

PMID:19402753[7]

MALDI(Z-score):23.393679

Protein

pstB

PMID:19402753[7]

MALDI(Z-score):30.495368

Protein

metK

PMID:19402753[7]

MALDI(Z-score):36.974428

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):25.424864

Protein

yqeI

PMID:19402753[7]

MALDI(Z-score):17.053160

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSFDIAKYPT LALVDSTQEL RLLPKESLPK LCDELRRYLL DSVSRSSGHF ASGLGTVELT
VALHYVYNTP FDQLIWDVGH QAYPHKILTG RRDKIGTIRQ KGGLHPFPWR GESEYDVLSV
GHSSTSISAG IGIAVAAEKE GKNRRTVCVI GDGAITAGMA FEAMNHAGDI RPDMLVILND
NEMSISENVG ALNNHLAQLL SGKLYSSLRE GGKKVFSGVP PIKELLKRTE EHIKGMVVPG
TLFEELGFNY IGPVDGHDVL GLITTLKNMR DLKGPQFLHI MTKKGRGYEP AEKDPITFHA
VPKFDPSSGC LPKSSGGLPS YSKIFGDWLC ETAAKDNKLM AITPAMREGS GMVEFSRKFP
DRYFDVAIAE QHAVTFAAGL AIGGYKPIVA IYSTFLQRAY DQVLHDVAIQ KLPVLFAIDR
AGIVGADGQT HQGAFDLSYL RCIPEMVIMT PSDENECRQM LYTGYHYNDG PSAVRYPRGN
AVGVELTPLE KLPIGKGIVK RRGEKLAILN FGTLMPEAAK VAESLNATLV DMRFVKPLDE
ALILEMAASH EALVTVEENA IMGGAGSGVN EVLMAHRKPV PVLNIGLPDF FIPQGTQEEM
RAELGLDAAG MEAKIKAWLA
Length

620

Mol. Wt

67.618 kDa

pI

6.6 (calculated)

Extinction coefficient

50,310 - 51,060 (calc based on 19 Y, 4 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P77488

Domain

318..482

PF02779 Transketolase, pyrimidine binding domain

PMID:19920124[8]

Domain

495..611

PF02780 Transketolase, C-terminal domain

PMID:19920124[8]

Domain

93..192

PF00676 Dehydrogenase E1 component

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dxs taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128405

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945060

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001461

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P77488

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6237

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13612

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945060

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002848

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3378

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 8.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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