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Standard Name	dpiA
Gene Synonym(s)	citB, ECK0613, b0620, JW0612, criR, mpdA^[1]^[2], mpdA
Product Desc.	DNA-binding response regulator in two-component regulatory system with CitA^[3]; DNA-binding response regulator in two-component regulatory system with DpiB^[2] Two-component system sensor protein; cognate thistidine protein kinase is DpiB; regulates citCDEFXGT operon; represses appY; destabilizes plasmid inheritance^[4]
Product Synonyms(s)	DNA-binding response regulator in two-component regulatory system with citA^[1], B0620^[3]^[1], MpdA^[3]^[1], CriR^[3]^[1], DpiA^[3]^[1], CitB^[3]^[1] , citB, criR, ECK0613, JW0612, mpdA, b0620
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): citA^[3]
Regulation/Activity
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Notes

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Gene

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Nomenclature

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Standard name	dpiA
Mnemonic	Destabilizer of plasmid inheritance
Synonyms	citB, ECK0613, b0620, JW0612, criR, mpdA^[1]^[2], mpdA
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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	14.08 minutes	MG1655: 653085..653765 <gbrowseImage> name=NC_000913:653085..653765 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 636450..637130 <gbrowseImage> name=NC_012967:636450..637130 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 555845..556525 <gbrowseImage> name=NC_012759:555845..556525 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 653085..653765 <gbrowseImage> name=NC_007779:653085..653765 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
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Notes

Sequence Features

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Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Alleles and Phenotypes

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Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔcitB758::kan					PMID:16738554	CGSC:100318
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Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
	Plasmid clone	Shigen	PMID:16769691 Status: Primer 1: Primer 2:
3G5	Kohara Phage	Genobase	PMID:3038334
1G6	Kohara Phage	Genobase	PMID:3038334
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc	EcoCyc:G6346	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13544	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002953	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947008	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3314	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002131	Escherichia coli str. K-12 substr. MG1655
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Name	URL	Comments
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Product(s)

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Nomenclature

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Standard name	CitB
Synonyms	DNA-binding response regulator in two-component regulatory system with citA^[1], B0620^[3]^[1], MpdA^[3]^[1], CriR^[3]^[1], DpiA^[3]^[1], CitB^[3]^[1] , citB, criR, ECK0613, JW0612, mpdA, b0620
Product description	DNA-binding response regulator in two-component regulatory system with CitA^[3]; DNA-binding response regulator in two-component regulatory system with DpiB^[2] Two-component system sensor protein; cognate thistidine protein kinase is DpiB; regulates citCDEFXGT operon; represses appY; destabilizes plasmid inheritance^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000156	two-component response regulator activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001789	F	Seeded from EcoCyc (v14.0)	complete
	GO:0000156	two-component response regulator activity	PMID:18997424^[5]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc (v14.0)	complete
	GO:0000156	two-component response regulator activity	PMID:19202292^[6]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc (v14.0)	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001789	P	Seeded from EcoCyc (v14.0)	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0902	P	Seeded from EcoCyc (v14.0)	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	PMID:18997424^[5]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc (v14.0)	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	PMID:19202292^[6]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc (v14.0)	complete
	GO:0003677	DNA binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006350	transcription	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006355	regulation of transcription, DNA-dependent	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001789	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	trmJ	PMID:16606699^[7]	Experiment(s):EBI-1137454
Protein	serC	PMID:16606699^[7]	Experiment(s):EBI-1137454
Protein	atoB	PMID:16606699^[7]	Experiment(s):EBI-1137454
Protein	fimC	PMID:16606699^[7]	Experiment(s):EBI-1137454
Protein	prs	PMID:16606699^[7]	Experiment(s):EBI-1137454
Protein	yeiT	PMID:19402753^[8]	LCMS(ID Probability):99.6
Protein	aegA	PMID:19402753^[8]	LCMS(ID Probability):99.6
Protein	gltD	PMID:19402753^[8]	LCMS(ID Probability):99.6 MALDI(Z-score):29.029594
Protein	gltB	PMID:19402753^[8]	LCMS(ID Probability):99.6 MALDI(Z-score):12.944989
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Notes

Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MTAPLTLLIV EDETPLAEMH AEYIRHIPGF SQILLAGNLA QARMMIERFK PGLILLDNYL PDGRGINLLH ELVQAHYPGD VVFTTAASDM ETVSEAVRCG VFDYLIKPIA YERLGQTLTR FRQRKHMLES IDSASQKQID EMFNAYARGE PKDELPTGID PLTLNAVRKL FKEPGVQHTA ETVAQALTIS RTTARRYLEY CASRHLIIAE IVHGKVGRPQ RIYHSG
Length	226
Mol. Wt	25.453 kDa
pI	7.0 (calculated)
Extinction coefficient	13,410 - 13,660 (calc based on 9 Y, 0 W, and 2 C residues)
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Domains/Motifs/Modification Sites

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Type	Residues	Description	References
Domain	7..119	PF00072 Response regulator receiver domain	PMID:19920124^[9]
Domain	134..162	PF12431 Transcriptional regulator	PMID:19920124^[9]
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<motif_map/>

Structure
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Structures

<beststructure> gene=dpiA taxon=562,83333 </beststructure>

Models

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Structure figures

Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128603	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947008	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002131	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AEF4	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6346	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13544	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947008	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002953	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3314	Escherichia coli str. K-12 substr. MG1655
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Notes

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	Ecoli K-12	1.062+/-0.036	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.006617647	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	229	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	60	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	59^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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Transcription unit(s)
citA
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File:.jpg

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<gbrowseImage> name=NC_000913:653065..653105 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

</protect>

Notes

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Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0620 (EcoliWiki Page)	NCBI GEO profiles for dpiA
microarray	GenExpDB:b0620 (EcoliWiki Page)	Summary of data for dpiA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to dpiA Expression

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Database	Accession	Notes
EcoCyc	EcoCyc:G6346	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3314	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0620
EcoGene	EcoGene:EG13544	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002953	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002131	Escherichia coli str. K-12 substr. MG1655
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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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Organism	Homologs (Statistics)	Comments
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Do-It-Yourself Web Tools

Notes

Families

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Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:52172
Panther (EcoliWiki Page)	PTHR26402:SF225
Pfam (EcoliWiki Page)	PF00072 Response regulator receiver domain
Pfam (EcoliWiki Page)	PF12431 Transcriptional regulator
EcoCyc	EcoCyc:G6346	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13544	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002953	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3314	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002131	Escherichia coli str. K-12 substr. MG1655
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Notes

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 Yamamoto, K et al. (2008) Anaerobic regulation of citrate fermentation by CitAB in Escherichia coli. Biosci. Biotechnol. Biochem. 72 3011-4 PubMed
↑ ^6.0 ^6.1 Yamamoto, K et al. (2009) Characterization of CitA-CitB signal transduction activating genes involved in anaerobic citrate catabolism in Escherichia coli. Biosci. Biotechnol. Biochem. 73 346-50 PubMed
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
↑ ^8.0 ^8.1 ^8.2 ^8.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
↑ ^9.0 ^9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

dpiA:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

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Alleles and Phenotypes

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Genetic Interactions

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Genetic Resources

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Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to dpiA Expression

Notes

Links

Evolution

Homologs in Other Organisms

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Notes

Families

Notes

Links

References

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