dfp:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Dfp

Synonyms

fused 4'-phosphopantothenoylcysteine decarboxylase[1], phosphopantothenoylcysteine synthetase, FMN-binding[1], B3639[2][1], DnaS[2][1], Dfp[2][1] , coaBC, ECK3629, JW5642, b3639

Product description

EG10004[2][3]

Coenzyme A biosynthesis, bifunctional enzyme; phosphopantothenoylcysteine decarboxylase (N) and phosphopantothenoylcysteine synthase (C)[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0004632

phosphopantothenate--cysteine ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005252

F

Seeded from EcoCyc (v14.0)

complete

GO:0004632

phosphopantothenate--cysteine ligase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.3.2.5

F

Seeded from EcoCyc (v14.0)

complete

GO:0004633

phosphopantothenoylcysteine decarboxylase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005252

F

Seeded from EcoCyc (v14.0)

complete

GO:0004633

phosphopantothenoylcysteine decarboxylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.1.36

F

Seeded from EcoCyc (v14.0)

complete

GO:0010181

FMN binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005252

F

Seeded from EcoCyc (v14.0)

complete

GO:0015937

coenzyme A biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005252

P

Seeded from EcoCyc (v14.0)

complete

GO:0015941

pantothenate catabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005252

P

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rplA

PMID:15690043[5]

Experiment(s):EBI-882623

Protein

rpoA

PMID:15690043[5]

Experiment(s):EBI-890190
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKARQQKYCD KIANFWCHPT GKIIMSLAGK KIVLGVSGGI AAYKTPELVR RLRDRGADVR
VAMTEAAKAF ITPLSLQAVS GYPVSDSLLD PAAEAAMGHI ELGKWADLVI LAPATADLIA
RVAAGMANDL VSTICLATPA PVAVLPAMNQ QMYRAAATQH NLEVLASRGL LIWGPDSGSQ
ACGDIGPGRM LDPLTIVDMA VAHFSPVNDL KHLNIMITAG PTREPLDPVR YISNHSSGKM
GFAIAAAAAR RGANVTLVSG PVSLPTPPFV KRVDVMTALE MEAAVNASVQ QQNIFIGCAA
VADYRAATVA PEKIKKQATQ GDELTIKMVK NPDIVAGVAA LKDHRPYVVG FAAETNNVEE
YARQKRIRKN LDLICANDVS QPTQGFNSDN NALHLFWQDG DKVLPLERKE LLGQLLLDEI
VTRYDEKNRR
Length

430

Mol. Wt

46.3 kDa

pI

8.5 (calculated)

Extinction coefficient

35,410 - 36,160 (calc based on 9 Y, 4 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0ABQ0

Domain

186..384

PF04127 DNA / pantothenate metabolism flavoprotein

PMID:19920124[6]

Domain

6..123

PF02441 Flavoprotein

PMID:19920124[6]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dfp taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111624

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949047

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011896

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABQ0

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10004

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10004

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949047

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000004

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0004

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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