clpA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ClpA

Synonyms

ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity[1], B0882[2][1], LopD[2][1], CipA[2][1], ClpA[2][1] , ECK0873, JW0866, lopD, b0882

Product description

ATP-binding component of serine protease[2][3];

Component of ClpA ATP-dependent protease specificity component and chaperone[3]; ClpAXP[3]; ClpAP[3]

ATPase subunit of ClpAP ATP-dependent protease; protease Ti; molecular chaperone[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004176

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001270

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003959

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013093

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018368

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0017111

nucleoside-triphosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0019538

protein metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004176

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of ClpA ATP-dependent protease specificity component and chaperone

could be indirect

Protein

mukB

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

rho

PMID:15690043[5]

Experiment(s):EBI-884758, EBI-891593

Protein

rplE

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

rplJ

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

rpoB

PMID:15690043[5]

Experiment(s):EBI-884758, EBI-879304

Protein

rpoC

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

rpsA

PMID:15690043[5]

Experiment(s):EBI-884758, EBI-891593

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-884758, EBI-891593

Protein

rpsD

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

rpsG

PMID:15690043[5]

Experiment(s):EBI-884758, EBI-891593

Protein

secA

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

spoT

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-884758

Protein

rpsF

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpsJ

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpsN

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpsP

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpsU

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

sbcC

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

ybjE

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

ygiF

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

yhbY

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

clpS

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

barA

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

proV

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

purL

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rhsC

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rplI

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rplM

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rplR

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rplU

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpmA

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpmC

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

rpmG

PMID:15690043[5]

Experiment(s):EBI-891593

Protein

ybaA

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

fdnH

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

ppk

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

rplB

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

fhuA

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

yciH

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

cadA

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

cheY

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

rplQ

PMID:16606699[6]

Experiment(s):EBI-1138254

Protein

rpmG

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

purL

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ygiF

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsU

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplU

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsF

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplI

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplR

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplM

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rhsC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

sbcC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpmA

PMID:19402753[7]

LCMS(ID Probability):99.2

Protein

rpsJ

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsA

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):22.764725

Protein

rho

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

rplD

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

yhbY

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

proV

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

clpS

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ybjE

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

barA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

Subunits of ClpAXP

could be indirect

Protein

Subunits of ClpAP

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLNQELELSL NMAFARAREH RHEFMTVEHL LLALLSNPSA REALEACSVD LVALRQELEA
FIEQTTPVLP ASEEERDTQP TLSFQRVLQR AVFHVQSSGR NEVTGANVLV AIFSEQESQA
AYLLRKHEVS RLDVVNFISH GTRKDEPTQS SDPGSQPNSE EQAGGEERME NFTTNLNQLA
RVGGIDPLIG REKELERAIQ VLCRRRKNNP LLVGESGVGK TAIAEGLAWR IVQGDVPEVM
ADCTIYSLDI GSLLAGTKYR GDFEKRFKAL LKQLEQDTNS ILFIDEIHTI IGAGAASGGQ
VDAANLIKPL LSSGKIRVIG STTYQEFSNI FEKDRALARR FQKIDITEPS IEETVQIING
LKPKYEAHHD VRYTAKAVRA AVELAVKYIN DRHLPDKAID VIDEAGARAR LMPVSKRKKT
VNVADIESVV ARIARIPEKS VSQSDRDTLK NLGDRLKMLV FGQDKAIEAL TEAIKMARAG
LGHEHKPVGS FLFAGPTGVG KTEVTVQLSK ALGIELLRFD MSEYMERHTV SRLIGAPPGY
VGFDQGGLLT DAVIKHPHAV LLLDEIEKAH PDVFNILLQV MDNGTLTDNN GRKADFRNVV
LVMTTNAGVR ETERKSIGLI HQDNSTDAME EIKKIFTPEF RNRLDNIIWF DHLSTDVIHQ
VVDKFIVELQ VQLDQKGVSL EVSQEARNWL AEKGYDRAMG ARPMARVIQD NLKKPLANEL
LFGSLVDGGQ VTVALDKEKN ELTYGFQSAQ KHKAEAAH
Length

758

Mol. Wt

84.207 kDa

pI

6.3 (calculated)

Extinction coefficient

32,890 - 33,265 (calc based on 11 Y, 3 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

210..347

PF00004 ATPase family associated with various cellular activities (AAA)

PMID:19920124[8]

Domain

13..63

PF02861 Clp amino terminal domain

PMID:19920124[8]

Domain

486..647

PF07724 AAA domain (Cdc48 subfamily)

PMID:19920124[8]

Domain

653..742

PF10431 C-terminal, D2-small domain, of ClpB protein

PMID:19920124[8]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=clpA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128850

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945764

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003001

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABH9

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10156

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10156

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945764

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000152

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0154

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 5.31 5.32 5.33 5.34 5.35 5.36 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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