bamA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

BamA

Synonyms

conserved protein[1], B0177[2][1], YzzN[2][1], YzzY[2][1], EcfK[2][1], YaeT[2][1], BamA [3], ecfK, ECK0176, JW0172, omp85, yaeT, yzzN, yzzY, b0177

Product description

YaeT[2]; YaeT-component of outer membrane protein assembly complex[4];

Component of Outer Membrane Protein Assembly Complex[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0043165

Gram-negative-bacterium-type cell outer membrane assembly

PMID:15851030[5]

IPI: Inferred from Physical Interaction

EcoliWiki:yfgL EcoliWiki:nlpB EcoliWiki:yfiO


P

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01430

C

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:15851030[5]

IPI: Inferred from Physical Interaction

EcoliWiki:nlpB EcoliWiki:yfgL EcoliWiki:yfiO


F

complete

GO:0009279

cell outer membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0040

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of Outer Membrane Protein Assembly Complex

Protein

skp

PMID:19402753[6]

LCMS(ID Probability):99.5

Protein

edd

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

gldA

PMID:19402753[6]

LCMS(ID Probability):99.4

Protein

yegQ

PMID:19402753[6]

MALDI(Z-score):27.086609

Protein

fur

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

acnB

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

gcvP

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

gabD

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

deoA

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

aldA

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

folD

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

BamB (yfgL)

BamB directly binds BamA (YaeT). Interaction between BamA-BamB is independent of BamA-BamCDE interactions. [7],[8]

Protein

BamC (nlpB)

BamC is part of the BamCDE sub-complex that binds to BamA (YaeT). Interaction of BamCDE sub-complex with BamA is independent of BamA-BamB interaction. [7],[8]

Protein

BamD (yfiO)

BamD is part of the BamCDE sub-complex that binds to BamA (YaeT). BamD directly binds BamA. Interaction of BamCDE sub-complex with BamA is independent of BamA-BamB interaction. [7],[8]

Protein

BamE (smpA)

BamE is part of the BamCDE sub-complex that binds to BamA (YaeT). Interaction of BamCDE sub-complex with BamA is independent of BamA-BamB interaction. [8]


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

outer membrane

Outer Membrane

PMID:15951436[9], PMID:16102012[10], PMID:9298646[11]

EchoLocation:ecfK

Outer Membrane

PMID:9298646

EchoLocation:ecfK


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAMKKLLIAS LLFSSATVYG AEGFVVKDIH FEGLQRVAVG AALLSMPVRT GDTVNDEDIS
NTIRALFATG NFEDVRVLRD GDTLLVQVKE RPTIASITFS GNKSVKDDML KQNLEASGVR
VGESLDRTTI ADIEKGLEDF YYSVGKYSAS VKAVVTPLPR NRVDLKLVFQ EGVSAEIQQI
NIVGNHAFTT DELISHFQLR DEVPWWNVVG DRKYQKQKLA GDLETLRSYY LDRGYARFNI
DSTQVSLTPD KKGIYVTVNI TEGDQYKLSG VEVSGNLAGH SAEIEQLTKI EPGELYNGTK
VTKMEDDIKK LLGRYGYAYP RVQSMPEIND ADKTVKLRVN VDAGNRFYVR KIRFEGNDTS
KDAVLRREMR QMEGAWLGSD LVDQGKERLN RLGFFETVDT DTQRVPGSPD QVDVVYKVKE
RNTGSFNFGI GYGTESGVSF QAGVQQDNWL GTGYAVGING TKNDYQTYAE LSVTNPYFTV
DGVSLGGRLF YNDFQADDAD LSDYTNKSYG TDVTLGFPIN EYNSLRAGLG YVHNSLSNMQ
PQVAMWRYLY SMGEHPSTSD QDNSFKTDDF TFNYGWTYNK LDRGYFPTDG SRVNLTGKVT
IPGSDNEYYK VTLDTATYVP IDDDHKWVVL GRTRWGYGDG LGGKEMPFYE NFYAGGSSTV
RGFQSNTIGP KAVYFPHQAS NYDPDYDYEC ATQDGAKDLC KSDDAVGGNA MAVASLEFIT
PTPFISDKYA NSVRTSFFWD MGTVWDTNWD SSQYSGYPDY SDPSNIRMSA GIALQWMSPL
GPLVFSYAQP FKKYDGDKAE QFQFNIGKTW
Length

810

Mol. Wt

90.553 kDa

pI

4.8 (calculated)

Extinction coefficient

141,530 - 141,780 (calc based on 47 Y, 13 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-20

UniProt Manual:Signal Peptides

UniProt:P0A940

Domain

448..810

PF01103 Surface antigen

PMID:19920124[12]

Domain

24..91

PF07244 Surface antigen variable number repeat

PMID:19920124[12]

Domain

92..172

PF07244 Surface antigen variable number repeat

PMID:19920124[12]

Domain

175..263

PF07244 Surface antigen variable number repeat

PMID:19920124[12]

Domain

266..344

PF07244 Surface antigen variable number repeat

PMID:19920124[12]

Domain

347..421

PF07244 Surface antigen variable number repeat

PMID:19920124[12]

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Structure
<protect> See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=bamA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128170

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944870

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000605

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A940

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6093

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12676

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944870

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002713

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2541

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ 5.0 5.1 Wu, T et al. (2005) Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell 121 235-45 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ 7.0 7.1 7.2 Malinverni, JC et al. (2006) YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Mol. Microbiol. 61 151-64 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 Sklar, JG et al. (2007) Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 104 6400-5 PubMed
  9. ↑ Doerrler, WT & Raetz, CR (2005) Loss of outer membrane proteins without inhibition of lipid export in an Escherichia coli YaeT mutant. J. Biol. Chem. 280 27679-87 PubMed
  10. ↑ Werner, J & Misra, R (2005) YaeT (Omp85) affects the assembly of lipid-dependent and lipid-independent outer membrane proteins of Escherichia coli. Mol. Microbiol. 57 1450-9 PubMed
  11. ↑ Link, AJ et al. (1997) Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis 18 1259-313 PubMed
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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