ackA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AckA

Synonyms

acetate kinase A and propionate kinase 2[1], B2296[2][1], AckA[2][1], propionate kinase 2[2][1], acetate kinase A[2][1] , ECK2290, JW2293, b2296

Product description

Acetate kinase, produces acetyl phosphate; mutants are fluoroacetate resistant; creBC regulon; binds Zn(II)[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[4]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006082

organic acid metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004372

P

Seeded from EcoCyc (v14.0)

complete

GO:0008776

acetate kinase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00020

F

Seeded from EcoCyc (v14.0)

complete

GO:0008776

acetate kinase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.2.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[4]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016310

phosphorylation

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00020

P

Seeded from EcoCyc (v14.0)

complete

GO:0016310

phosphorylation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000890

P

Seeded from EcoCyc (v14.0)

complete

GO:0019542

propionate biosynthetic process

PMID:9484901[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:tdcD


P

complete

GO:0019413

acetate biosynthetic process

PMID:9484901[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:tdcD


P

complete

GO:0008776

acetate kinase activity

PMID:2536666[6]

IDA: Inferred from Direct Assay

F

complete

GO:0008270

zinc ion binding

PMID:11985624[7]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

hemX

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

ybgA

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

def

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

hyfE

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

fur

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

kdsD

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

greB

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

glyA

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

moaC

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

rpmB

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

ahpC

PMID:16606699[8]

Experiment(s):EBI-1142466

Protein

greA

PMID:16606699[8]

Experiment(s):EBI-1142466
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSSKLVLVLN CGSSSLKFAI IDAVNGEEYL SGLAECFHLP EARIKWKMDG NKQEAALGAG
AAHSEALNFI VNTILAQKPE LSAQLTAIGH RIVHGGEKYT SSVVIDESVI QGIKDAASFA
PLHNPAHLIG IEEALKSFPQ LKDKNVAVFD TAFHQTMPEE SYLYALPYNL YKEHGIRRYG
AHGTSHFYVT QEAAKMLNKP VEELNIITCH LGNGGSVSAI RNGKCVDTSM GLTPLEGLVM
GTRSGDIDPA IIFHLHDTLG MSVDAINKLL TKESGLLGLT EVTSDCRYVE DNYATKEDAK
RAMDVYCHRL AKYIGAYTAL MDGRLDAVVF TGGIGENAAM VRELSLGKLG VLGFEVDHER
NLAARFGKSG FINKEGTRPA VVIPTNEELV IAQDASRLTA
Length

400

Mol. Wt

43.29 kDa

pI

6.2 (calculated)

Extinction coefficient

24,870 - 25,620 (calc based on 13 Y, 1 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

5..393

PF00871 Acetokinase family

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ackA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130231

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946775

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007579

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6A3

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10027

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10027

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946775

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000024

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0026

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  5. ↑ 5.0 5.1 Hesslinger, C et al. (1998) Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate. Mol. Microbiol. 27 477-92 PubMed
  6. ↑ Matsuyama, A et al. (1989) Cloning, expression, and nucleotide sequence of the Escherichia coli K-12 ackA gene. J. Bacteriol. 171 577-80 PubMed
  7. ↑ Katayama, A et al. (2002) Systematic search for zinc-binding proteins in Escherichia coli. Eur. J. Biochem. 269 2403-13 PubMed
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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