accB:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
AccB |
|---|---|
| Synonyms |
acetyl CoA carboxylase, BCCP subunit[1], B3255[2][1], FabE[2][1], [acetyl-CoA:carbon-dioxide ligase (ADP forming)][2][1], BCCP-biotin (monomer)[2][1], BCCP-biotin-CO2[2], biotin-BCCP (monomer)[2][1] , ECK3242, fabE, JW3223, b3255 |
| Product description |
biotinylated biotin-carboxyl carrier protein[2][3], carboxybiotin-carboxyl-carrier protein[2][3]; Component of AccB transcriptional repressor; biotin carboxyl carrier protein (dimer)[2][3]; acetyl CoA carboxylase[2][3] Acetyl-CoA carboxylase, biotin carboxyl carrier protein; BCCP; homodimeric[4] |
| EC number (for enzymes) |
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| edit table |
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Notes
Function
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Gene Ontology
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See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003989 |
acetyl-CoA carboxylase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006633 |
fatty acid biosynthetic process |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006633 |
fatty acid biosynthetic process |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006633 |
fatty acid biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0009317 |
acetyl-CoA carboxylase complex |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009374 |
biotin binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006633 |
fatty acid biosynthetic process |
IGI: Inferred from Genetic Interaction |
EcoliWiki:accA EcoliWiki:accC EcoliWiki:accD
|
P |
complete | |||
| GO:0003989 |
acetyl-CoA carboxylase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
| GO:0005737 |
cytoplasm |
IC: Inferred by Curator |
GO:0003989
|
C |
complete | |||
| GO:0006633 |
fatty acid biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
Fig 3: TLC showing excess FFA production in mutants over-expressing ACC. Table II shows relative FFA production higher in mutants over-expressing ACC than controls. |
complete | |||
| edit table |
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Interactions
<protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
gltX |
Experiment(s):EBI-1145305 | ||
|
Protein |
rpsC |
Experiment(s):EBI-1145305 | ||
|
Protein |
accC |
Experiment(s):EBI-1145305, EBI-1145313 | ||
|
Protein |
ykgF |
Experiment(s):EBI-1145305 | ||
|
Protein |
pmbA |
Experiment(s):EBI-1145305 | ||
|
Protein |
dnaK |
Experiment(s):EBI-1145305 | ||
|
Protein |
Subunits of AccB transcriptional repressor; biotin carboxyl carrier protein (dimer) |
could be indirect |
||
|
Protein |
Subunits of acetyl CoA carboxylase |
could be indirect |
| |
| edit table |
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MDIRKIKKLI ELVEESGISE LEISEGEESV RISRAAPAAS FPVMQQAYAA PMMQQPAQSN AAAPATVPSM EAPAAAEISG HIVRSPMVGT FYRTPSPDAK AFIEVGQKVN VGDTLCIVEA MKMMNQIEAD KSGTVKAILV ESGQPVEFDE PLVVIE |
| Length |
156 |
| Mol. Wt |
16.686 kDa |
| pI |
4.5 (calculated) |
| Extinction coefficient |
2,980 - 3,105 (calc based on 2 Y, 0 W, and 1 C residues) |
| edit table |
Domains/Motifs/Modification Sites
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<motif_map/> |
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Structure
| </protect>
Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 5.3 5.4 Davis, MS et al. (2000) Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli. J. Biol. Chem. 275 28593-8 PubMed
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
- ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
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