Phage lambda cI:On One Page
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Quickview | | Gene | | Product(s) | | Expression| | Evolution | | References | |
Quickview
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| Standard Name |
Phage lambda cI |
|---|---|
| Gene Synonym(s) |
cI, lambdap88 |
| Product Desc. |
repressor |
| Product Synonyms(s) |
cI, lambdap88 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>
Notes
cI = c for clear, roman I for one of three complementation groups with clear plaque phenotypes. cI is required for both establishment and maintenance of lysogeny.
Gene
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Nomenclature
See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.
| Standard name |
Phage lambda cI |
|---|---|
| Mnemonic | |
| Synonyms |
cI, lambdap88 |
| edit table |
See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table. </protect>
Notes
cI is c for clear plaque and Roman numeral I for one of three complementation groups that give clear plaques.
Location(s) and DNA Sequence
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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.
| Strain | Map location | Genome coordinates | Genome browsers | Sequence links |
|---|---|---|---|---|
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NC_012759: 4142828..4143541 |
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NC_001416 |
NC_001416: 37940..37227 |
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| edit table |
See Help:Gene_location for help entering information in the Gene Location and DNA sequence table. </protect>
Notes
Sequence Features
See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.
| Feature Type | Strain | Genomic Location | Evidence | Reference | Notes |
|---|---|---|---|---|---|
| edit table |
See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki. <protect></protect>
Notes
Alleles and Phenotypes
See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.
| Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments |
|---|---|---|---|---|---|---|---|
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cIam504 |
g →c on the + strand at bp 37308 |
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cIam14 |
c →a on the + strand at bp 37287 |
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cIam505 |
g →a on the + strand at bp 37313 |
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ind1 |
c →t on the + strand at bp 37589 |
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cIam499 |
g →c on the + strand at bp 37629 |
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cIam212 |
a →c on the + strand at bp 37635 |
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cIam34 |
c →a on the + strand at bp 37680 |
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strain ci857s7([25]) |
c →t on the + strand at bp 37742 |
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cIam282 |
g →a on the + strand at bp 37808 |
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cIam302 |
a →c on the + strand at bp 37872 |
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| edit table |
See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki. <protect></protect>
Notes
Genetic Interactions
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| Interactor | Interaction | Allele | Score(s) | Reference(s) | Accessions | Notes |
|---|---|---|---|---|---|---|
| edit table |
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Notes
Genetic Resources
See Help:Gene_resources for help entering information into the Genetic Resources table.
| Resource | Resource Type | Source | Notes/Reference |
|---|---|---|---|
| edit table |
See Help:Gene_resources for help entering information into the Genetic Resources table. <protect></protect>
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
| edit table |
See Help:Gene_accessions for help with entering information into the Gene Accessions table. <protect></protect>
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
Product(s)
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Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
cI |
|---|---|
| Synonyms |
cI, lambdap88 |
| Product description |
repressor |
| EC number (for enzymes) |
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| edit table |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
GO:0004175 |
endopeptidase activity |
PMID:14733611 |
IDA: Inferred from Direct Assay |
F |
complete | |||
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GO:0097264 |
self proteolysis |
PMID:14733611 |
IDA: Inferred from Direct Assay |
P |
complete | |||
| edit table |
Interactions
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See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
| edit table |
</protect>
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MSTKKKPLTQ EQLEDARRLK AIYEKKKNEL GLSQESVADK MGMGQSGVGA LFNGINALNA YNAALLAKIL KVSVEEFSPS IAREIYEMYE AVSMQPSLRS EYEYPVFSHV QAGMFSPELR TFTKGDAERW VSTTKKASDS AFWLEVEGNS MTAPTGSKPS FPDGMLILVD PEQAVEPGDF CIARLGGDEF TFKKLIRDSG QVFLQPLNPQ YPMIPCNESC SVVGKVIASQ WPEETFG |
| Length |
237 |
| Mol. Wt |
26.211 kDa |
| pI |
4.9 (calculated) |
| Extinction coefficient |
26,930 - 27,305 (calc based on 7 Y, 3 W, and 3 C residues) |
| edit table |
Domains/Motifs/Modification Sites
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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
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<motif_map/> |
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Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
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Structure figures
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Notes
Lambda repressor consists of an N-terminal DNA binding domain and a C-terminal oligomerization domain, connected by a flexible linker. The N-terminal domain in isolation dimerizes weakly through helix 5-helix 5 contacts. The C-terminal domain is required for dimerization and DNA binding at normal in vivo expression levels. Induction of phage lambda by the SOS response involves autoproteolysis at a specific site in the linker by the C-domain.
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
<protect></protect>
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
| edit table |
<protect></protect>
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
Expression
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Overview
This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Cellular Levels
| Molecule | Organism or Strain | Value | Units | Experimental Conditions | Assay used | Notes | Reference(s) |
|---|---|---|---|---|---|---|---|
| edit table |
Notes
Transcription and Transcriptional Regulation
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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.
|
See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki. </protect>
Notes
This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Translation and Regulation of Translation
<protect><gbrowseImage>
name=NC_001416:37920..37960
source=bacteriophage_lambda
flip=1
type=CDS+DNA
preset=Nterminus
</gbrowseImage>
This picture shows the sequence around the N-terminus.
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Notes
This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Turnover and Regulation of Turnover
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Notes
This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.
Experimental
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Mutations Affecting Expression
See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.
| Allele Name | Mutation | Phenotype | Reference |
|---|---|---|---|
| edit table |
See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.
Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.
| Type | Reference | Notes |
|---|---|---|
| edit table |
See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.
Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.
| Resource Name | Resource Type | Description | Source | Notes |
|---|---|---|---|---|
| edit table |
See Help:Expression_resources for help entering or editing information in this section of EcoliWiki. <protect></protect>
Notes
Accessions Related to Phage lambda cI Expression
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
| edit table |
See Help:Expression_accessions for help entering or editing information in this section of EcoliWiki. <protect></protect>
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
Evolution
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Homologs in Other Organisms
See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.
| Organism | Homologs (Statistics) | Comments |
|---|---|---|
| edit table |
See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.
Do-It-Yourself Web Tools
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Notes
Families
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
| edit table |
See Help:Evolution_families for help entering or editing information in this section of EcoliWiki. <protect></protect>
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
References
See Help:References for how to manage references in EcoliWiki.
Categories
