setB:Gene Product(s)

Standard name	SetB
Synonyms	lactose/glucose efflux system^[1], B2170^[2]^[1], YeiO^[2]^[1], SetB^[2]^[1]
Product description	SetB MFS transporter^[2]^[3] Glucose and lactose efflux transporter^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016021	integral to membrane	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004750 InterPro:IPR007114 SP_KW:KW-0812	C	Seeded from EcoCyc ^[5]	complete
	GO:0016020	membrane	GO_REF:0000004 GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0397 SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0015542	sugar efflux transmembrane transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004750	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0008643	carbohydrate transport	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR004750 SP_KW:KW-0762	P	Seeded from EcoCyc ^[5]	complete
	GO:0006810	transport	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR007114 SP_KW:KW-0813	P	Seeded from EcoCyc ^[5]	complete
	GO:0005351	sugar:hydrogen symporter activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0762	F	Seeded from EcoCyc ^[5]	complete
	GO:0015767	lactose transport	PMID:10438463^[7]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc ^[5]	complete
	GO:0005886	plasma membrane	GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc ^[5]	complete
	GO:0015292	uniporter activity				F	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0015758	glucose transport	PMID:10438463^[7]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc ^[5]	complete
	GO:0007059	chromosome segregation	PMID:14617174^[8]	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0016020	membrane	PMID:14617174^[8]	IDA: Inferred from Direct Assay		C		complete
	GO:0015767	lactose transport	PMID:10438463^[7]	IDA: Inferred from Direct Assay		P		complete
	GO:0015542	sugar efflux transmembrane transporter activity	PMID:10438463^[7]	IDA: Inferred from Direct Assay		F		complete
	GO:0015758	glucose transport	PMID:10438463^[7]	IDA: Inferred from Direct Assay		P		complete
	GO:0016020	membrane	PMID:10438463^[7]	IDA: Inferred from Direct Assay		C		complete
	GO:0005215	transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007114	F	Seeded from EcoCyc	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	MreB		PMID:14617174^[8]
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
plasma membrane	C-terminus localized in the cytoplasm with 12 predicted transmembrane domains	Daley et al. (2005) ^[9]
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MHNSPAVSSA KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP AMVGFFFTGS AVIGILVSQF LAGRSDKRGD RKSLIVFCCL LGVLACTLFA WNRNYFVLLF VGVFLSSFGS TANPQMFALA REHADKTGRE AVMFSSFLRA QVSLAWVIGP PLAYALAMGF SFTVMYLSAA VAFIVCGVMV WLFLPSMRKE LPLATGTIEA PRRNRRDTLL LFVICTLMWG SNSLYIINMP LFIINELHLP EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRFLMRVAAV GGVCFYAGML MAHSPVILLG LQLLNAIFIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTSR VGWIIAGSVA GIVAEIWNYH AVFWFAMVMI IATLFCLLRI KDV
Length	393
Mol. Wt	42.75 kDa (calc) ^[2]
pI
Extinction coefficient	51910 - 52785 (calc based on 9 Y, 7 W, and 7 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
Domain	84 - 101	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	105 - 124	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	145 - 167	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	172 - 194	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	222 - 244	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	254 - 276	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	283 - 302	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	307 - 329	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	350 - 367	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	371 - 388	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	13 - 35	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	50 - 72	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:B2170-MONOMER
UniProt (EcoliWiki Page)	UniProt:P33026
PFAM (EcoliWiki Page)	PFAM:PF07690
RefSeq (EcoliWiki Page)	RefSeq:NP_416675
ModBase (EcoliWiki Page)	ModBase:P33026
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^6.0 ^6.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Liu, JY et al. (1999) Functional and biochemical characterization of Escherichia coli sugar efflux transporters. J. Biol. Chem. 274 22977-84 PubMed
↑ ^8.0 ^8.1 ^8.2 Espeli, O et al. (2003) SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli. Mol. Microbiol. 50 495-509 PubMed
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

setB:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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setB:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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