PMID:14617174
| Citation |
Espeli, O, Nurse, P, Levine, C, Lee, C and Marians, KJ (2003) SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli. Mol. Microbiol. 50:495-509 |
|---|---|
| Abstract |
SetB was identified as a high-copy suppressor of the partition defect of a mutation in parC, encoding one of the subunits of topoisomerase IV. Deletion of this integral inner membrane protein causes a delay in chromosome segregation, whereas its overproduction causes nucleoid disintegration and stretching, leading to a cell division defect. setB deletion mutants also exhibit a synthetic phenotype when combined with mutations that delete the C-terminal motor domain of the septal ring protein FtsK. SetB localizes in the cell as a helix and interacts with MreB, the bacterial actin homologue, which also forms a helix. These observations suggest that there may be a link between chromosome segregation and cellular infrastructure. |
| Links | |
| Keywords |
Cell Division; Chromosome Segregation/physiology; Chromosomes, Bacterial/physiology; Escherichia coli/genetics; Escherichia coli Proteins/physiology; Membrane Proteins/physiology; Monosaccharide Transport Proteins/physiology |
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