arcB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ArcB

Synonyms

B3210[1][2], sensor kinase-phosphotransferase ArcB-Phis292[1][2]

Product description

hybrid sensory histidine kinase in two-component regulatory system with response regulator ArcA [2]

Tripartite sensor/histidine protein kinase; repression of aerobic genes and activationof some anerobic genes under anaerobic growth conditions; phosphorylates response regulator protein (ArcA); has respones regulator and second transmitter domains[3]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0000160

two-component signal transduction system (phosphorelay)

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000700
InterPro:IPR001789
SP_KW:KW-902

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0000155

two-component sensor activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700
InterPro:IPR003661

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0000156

two-component response regulator activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

F

Seeded from EcoCyc [5]

complete

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

Seeded from EcoCyc [5]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003661
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0004673

protein histidine kinase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR005467
EC:2.7.13.3

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0004871

signal transducer activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014
InterPro:IPR009082

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003594

F

Seeded from EcoCyc [5]

complete

GO:0006350

transcription

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc [5]

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001789
InterPro:IPR013767
SP_KW:KW-0805

P

Seeded from EcoCyc [5]

complete

GO:0007165

signal transduction

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014
InterPro:IPR003661
InterPro:IPR009082

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0016310

phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004358

P

Seeded from EcoCyc [5]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [5]

complete

GO:0018106

peptidyl-histidine phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005467

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0006464

protein modification process

P

Seeded from EcoCyc 11.1[6].

required fields missing

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [5]

complete

GO:0016485

protein processing

P

Seeded from EcoCyc 11.1[6].

required fields missing

GO:0009060

aerobic respiration

P

Seeded from EcoCyc 11.1[6].

required fields missing

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004358

F

Seeded from EcoCyc [5]

complete

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Interactions

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

 




Mol. Wt



87.98 kDa (calc) [1] 






pI






Extinction coefficient



0 (calc based on 0 Y, 0 W, and 0 C residues) 






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Domains/Motifs/Modification Sites
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.







Type
Residues
Description
Notes






Domain





527 - 643





Response regulatory





UniProt:P0AEC3 








Domain





678 - 771





HPt





UniProt:P0AEC3 








Domain





289 - 507





Histidine kinase





UniProt:P0AEC3 








Domain





153 - 223





PAS





UniProt:P0AEC3 








Domain





226 - 278





PAC





UniProt:P0AEC3 








Modification Site





717





Phosphohistidine (Probable)





UniProt:P0AEC3 








Modification Site





292 - 292





Phosphohistidine; by autocatalysis





UniProt:P0AEC3 








Modification Site





576 - 576





4-aspartylphosphate (Probable)





UniProt:P0AEC3 






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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.








Structures



<beststructure>arcB
562</beststructure>






Models



View models at:







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Notes


Gene Product Resources


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 See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.







Resource type
Source
Notes/Reference




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Notes


Accessions in Other Databases


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See Help:Gene_accessions for help with entering information into the Gene Accessions table.







Database
Accession
Notes






EcoCyc (EcoliWiki Page) 





EcoCyc:PHOSPHO-ARCB-HIS










SwissModel (EcoliWiki Page) 





SwissModel:P0AEC3










UniProt (EcoliWiki Page) 





UniProt:P0AEC3










PFAM (EcoliWiki Page) 





PFAM:PF00989










RefSeq (EcoliWiki Page) 





RefSeq:NP_417677










ModBase (EcoliWiki Page) 





ModBase:P0AEC3










PDB (EcoliWiki Page) 





PDB:1A0B













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Notes


Links


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Name
URL
Comments




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References


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  1. ↑ 1.0 1.1 1.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7  

    2. 

  2. ↑ 2.0 2.1 2.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)  

    3. 

  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.   

    4. 

  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7  

    5. 

  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70  

    6. 

  6. ↑ 6.0 6.1 6.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7  

    7. 








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