prs:Gene Product(s)

Standard name	PrsA
Synonyms	phosphoribosylpyrophosphate synthase^[1], B1207^[2]^[1], DnaR^[2]^[1], Prs^[2]^[1], PrsA^[2]^[1]
Product description	PRPPSYN^[2]^[3]
EC number (for enzymes)	2.7.6.1^[1]
edit table

Notes

Function

[back to top]

Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A6F5	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A7D1	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A9Q1	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A9T6	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0AF63	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P13458	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P36767	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P39176	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P60390	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q47005	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q47156	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005737	cytoplasm	PMID:16858726^[6]	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0009165	nucleotide biosynthetic process	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR005946 SP_KW:KW-0545	P	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0009156	ribonucleoside monophosphate biosynthetic process	GO_REF:0000002 GO_REF:0000020	IEA: Inferred from Electronic Annotation	InterPro:IPR000842 HAMAP:MF_00583	P	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0009116	nucleoside metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000836	P	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0004749	ribose phosphate diphosphokinase activity	GO_REF:0000002 GO_REF:0000002 GO_REF:0000003 GO_REF:0000020	IEA: Inferred from Electronic Annotation	InterPro:IPR000842 InterPro:IPR005946 EC:2.7.6.1 HAMAP:MF_00583	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0000287	magnesium ion binding	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004 GO_REF:0000020	IEA: Inferred from Electronic Annotation	InterPro:IPR000842 InterPro:IPR005946 SP_KW:KW-0460 HAMAP:MF_00583	F	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0009152	purine ribonucleotide biosynthetic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	npdA	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-881344, EBI-885898
Protein	dnaJ	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	dnaK	PMID:15690043^[7]	Experiment(s):EBI-880430
Protein	groL	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	mreB	PMID:15690043^[7]	Experiment(s):EBI-880430
Protein	rplB	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	rplE	PMID:15690043^[7]	Experiment(s):EBI-880430
Protein	rplJ	PMID:15690043^[7]	Experiment(s):EBI-880430
Protein	rplP	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	rpsB	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	rpsC	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	rpsD	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	rpsG	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	tufA	PMID:15690043^[7]	Experiment(s):EBI-880430, EBI-885898
Protein	rluB	PMID:15690043^[7]	Experiment(s):EBI-880430
Protein	yibA	PMID:15690043^[7]	Experiment(s):EBI-880430
Protein	nusG	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rho	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplC	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplD	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplI	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplK	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplL	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplM	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplN	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplO	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplS	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplU	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplV	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplW	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rplX	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rpmB	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rpsE	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rpsH	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rpsJ	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rpsP	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	rpsT	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	yfiF	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	yrfD	PMID:15690043^[7]	Experiment(s):EBI-885898
Protein	groL	PMID:16606699^[4]	Experiment(s):EBI-1139177
edit table

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
edit table

Notes

Structure and Physical Properties

[back to top]

Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MPDMKLFAGN ATPELAQRIA NRLYTSLGDA AVGRFSDGEV SVQINENVRG GDIFIIQSTC APTNDNLMEL VVMVDALRRA SAGRITAVIP YFGYARQDRR VRSARVPITA KVVADFLSSV GVDRVLTVDL HAEQIQGFFD VPVDNVFGSP ILLEDMLQLN LDNPIVVSPD IGGVVRARAI AKLLNDTDMA IIDKRRPRAN VSQVMHIIGD VAGRDCVLVD DMIDTGGTLC KAAEALKERG AKRVFAYATH PIFSGNAANN LRNSVIDEVV VCDTIPLSDE IKSLPNVRTL TLSGMLAEAI RRISNEESIS AMFEH
Mol. Wt	34.22 kDa (calc) ^[2]
pI	5.52^[2]
Extinction coefficient	5960 - 6460 (calc based on 4 Y, 0 W, and 4 C residues)
edit table

Domains/Motifs/Modification Sites See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
edit table

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

View models at:

edit table

Notes

Gene Product Resources

[back to top]

See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
edit table

Notes

Accessions in Other Databases

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:PRPPSYN-MONOMER
SwissModel (EcoliWiki Page)	SwissModel:P0A717
UniProt (EcoliWiki Page)	UniProt:P0A717
PFAM (EcoliWiki Page)	PFAM:PF00156
RefSeq (EcoliWiki Page)	RefSeq:NP_415725
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

References

[back to top]

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 ^5.17 ^5.18 ^5.19 ^5.20 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 ^7.24 ^7.25 ^7.26 ^7.27 ^7.28 ^7.29 ^7.30 ^7.31 ^7.32 ^7.33 ^7.34 ^7.35 ^7.36 ^7.37 ^7.38 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed

prs:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

prs:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

Search