lpxD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

LpxD product

Synonyms

UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase product[1], B0179 product[2][1], OmsA product[2][1], Ssc product[2][1], OsmA product[2][1], FirA product[2][1], LpxD product[2][1]

Product description

UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-MONO[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0008415

acyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001451

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008415

acyltransferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0008610

lipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0009245

lipid A biosynthetic process

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00523

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0009245

lipid A biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007691

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0009245

lipid A biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0016740

transferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011004

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0016747

transferase activity, transferring groups other than amino-acyl groups

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00523

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0016747

transferase activity, transferring groups other than amino-acyl groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007691

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0046677

response to antibiotic

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0046

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

required fields missing

GO:0042280

cell surface antigen activity, host-interacting

F

Seeded from Riley et al 2006 [1].

required fields missing

GO:0016410

N-acyltransferase activity

PMID:3288280[5]

IDA: Inferred from Direct Assay

F

complete

GO:0009245

lipid A biosynthetic process

PMID:8366125[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0016410

N-acyltransferase activity

PMID:8366125[6]

IDA: Inferred from Direct Assay

F

complete

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Interactions

Partner Type Partner Notes
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Notes

Localization

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MPSIRLADLA QQLDAELHGD GDIVITGVAS MQSAQTGHIT FMVNPKYREH LGLCQASAVV
MTQDDLPFAK SAALVVKNPY LTYARMAQIL DTTPQPAQNI APSAVIDATA KLGNNVSIGA
NAVIESGVEL GDNVIIGAGC FVGKNSKIGA GSRLWANVTI YHEIQIGQNC LIQSGTVVGA
DGFGYANDRG NWVKIPQIGR VIIGDRVEIG ACTTIDRGAL DDTIIGNGVI IDNQCQIAHN
VVIGDNTAVA GGVIMAGSLK IGRYCMIGGA SVINGHMEIC DKVTVTGMGM VMRPITEPGV
YSSGIPLQPN KVWRKTAALV MNIDDMSKRL KSLERKVNQQ D
Mol. Wt

36.04 kDa (calc) [2]

pI

6.48[2]

Extinction coefficient

26930 - 27805 (calc based on 7 Y, 3 W, and 7 C residues)

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Domains/Motifs/Modification Sites

Type Residues Description Notes
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Structure

Structure Type Organism Accession Residues covered Notes
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Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-MONO

UniProt (EcoliWiki Page)

UniProt:P21645

PFAM (EcoliWiki Page)

PFAM:PF04613

RefSeq (EcoliWiki Page)

RefSeq:NP_414721

ModBase (EcoliWiki Page)

ModBase:P21645

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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ Anderson, MS et al. (1988) Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine. Biochemistry 27 1908-17 PubMed
  6. ↑ 6.0 6.1 Kelly, TM et al. (1993) The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis. J. Biol. Chem. 268 19866-74 PubMed


Categories

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