fabI:Gene Product(s): Difference between revisions

Standard name	FabI product
Synonyms	enoyl-[acyl-carrier-protein] reductase, NADH-dependent product^[1], B1288 product^[2]^[1], Gts product^[2]^[1], QmeA product^[2]^[1], EnvM product^[2]^[1], FabI product^[2]^[1]
Product description	ENOYL-ACP-REDUCT-NADH-MONOMER^[2]^[3]
EC number (for enzymes)	1.3.1.9^[1]
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Notes

Function

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Gene Ontology

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0016491	oxidoreductase_activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002198	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0016491	oxidoreductase_activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002347	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0016491	oxidoreductase_activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0004318	enoyl-[acyl-carrier_protein]_reductase_(NADH)_activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.3.1.9	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005515	protein_binding	PMID:15690043^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P0AF90	F	Seeded from EcoCyc 12.5 ^[4]
	GO:0005624	membrane_fraction	PMID:16858726^[6]	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc 12.5 ^[4]
	GO:0006633	fatty_acid_biosynthesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0275	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0008152	metabolism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002198	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0008152	metabolism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002347	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0008610	lipid_biosynthesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0444	P	Seeded from EcoCyc 12.5 ^[4]
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0397	C	Seeded from EcoCyc 12.5 ^[4]
	GO:0005737	cytoplasm				C	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0006654	phosphatidic acid biosynthetic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0046677	response_to_antibiotic	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0046	P	Seeded from EcoCyc 12.5 ^[4]
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Interactions

Partner Type	Partner	Notes
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Notes

Localization

Compartment	Description	Evidence	Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MGFLSGKRIL VTGVASKLSI AYGIAQAMHR EGAELAFTYQ NDKLKGRVEE FAAQLGSDIV LQCDVAEDAS IDTMFAELGK VWPKFDGFVH SIGFAPGDQL DGDYVNAVTR EGFKIAHDIS SYSFVAMAKA CRSMLNPGSA LLTLSYLGAE RAIPNYNVMG LAKASLEANV RYMANAMGPE GVRVNAISAG PIRTLAASGI KDFRKMLAHC EAVTPIRRTV TIEDVGNSAA FLCSDLSAGI SGEVVHVDGG FSIAAMNELE LK
Mol. Wt	27.86 kDa (calc) ^[2]
pI	5.88^[2]
Extinction coefficient	15930 - 16430 (calc based on 7 Y, 1 W, and 4 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structure Type	Organism	Accession
X-RAY DIFFRACTION	Escherichia coli	1MFP E. coli Enoyl Reductase in complex with NAD and SB611113
X-RAY DIFFRACTION	Escherichia coli	1QSG CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN
X-RAY DIFFRACTION	Escherichia coli	1I30 E. COLI ENOYL REDUCTASE +NAD+SB385826
X-RAY DIFFRACTION	Escherichia coli	1I2Z E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654
X-RAY DIFFRACTION	Escherichia coli	1DFI X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD
X-RAY DIFFRACTION	Escherichia coli	1DFH X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND THIENO-DIAZABORINE
X-RAY DIFFRACTION	Escherichia coli	1DFG X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND BENZO-DIAZABORINE
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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER
SwissModel (EcoliWiki Page)	SwissModel:P0AEK4
UniProt (EcoliWiki Page)	UniProt:P0AEK4
PFAM (EcoliWiki Page)	PFAM:PF00106
RefSeq (EcoliWiki Page)	RefSeq:NP_415804
PDB (EcoliWiki Page)	PDB:1DFG
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed

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+[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
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-[[Category:GO:0016491_!_oxidoreductase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016491_!_oxidoreductase_activity GO:0016491]
+[[Category:GO:0046677_!_response_to_antibiotic]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0046677_!_response_to_antibiotic GO:0046677]
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fabI:Gene Product(s): Difference between revisions

Revision as of 00:15, 30 September 2008

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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fabI:Gene Product(s): Difference between revisions

Revision as of 00:15, 30 September 2008

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

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