Essential genes

Introduction and caveats

This page displays a list of E. coli genes that may be essential. The list is generated by removing all genes where Keio deletions have been isolated, and all ins genes that are from insertion elements. The list was then manually curated to remove obvious pseudogenes. Community curation is needed to improve the quality of this list. Genes can be removed from the list by editing the list of gene pages in the wikitext of this page

<essentialGenes>
nonessential gene 1:Gene
nonessential gene 2:Gene
etc.
</essentialGenes>

tRNA genes that can be mutated to nonsense suppressors are marked as nonessential. Note that in many cases these are redundant and not all copies of a tRNA isoacceptor can be simultaneously deleted. Similarly, although ribosomal RNA genes are not on this list, at least one of each rRNA is needed for viability.

The list (Edit this)

<essentialGenes> List nonessential gene pages here accD:Gene arpB_2:Gene degS:Gene dpiA:Gene dpiB:Gene dsbD:Gene efeU_2:Gene entD:Gene etk:Gene eutD:Gene eutK:Gene eutM:Gene eutR:Gene eutS:Gene fldA:Gene folA:Gene folD:Gene ftnA:Gene ftnB:Gene ftsN:Gene ftsX:Gene gapC_1:Gene gatA:Gene gatR_2:Gene glcA:Gene glnU:Gene glnV:Gene glnX:Gene gpsA:Gene gsp:Gene hflB:Gene ilvG_2:Gene istR-1:Gene istR-2:Gene intZ:Gene kup:Gene lacZ:Gene leuX:Gene lolA:Gene lomR_2:Gene lysT:Gene lyx:Gene mazE:Gene mazF:Gene micF:Gene mraY:Gene mreD:Gene molR_3:Gene mug:Gene murA:Gene murB:Gene murF:Gene nadD:Gene oriC:Gene orn:Gene pgmB:Gene pinE:Gene pptA:Gene ptrA:Gene purB:Gene qmcA:Gene queC:Gene queF:Gene raiA:Gene ravA:Gene rcnA:Gene rimN:Gene rlmG:Gene rlmL:Gene rluE:Gene rluF:Gene rnlA:Gene rpsG:Gene rplP:Gene rplV:Gene rpsF:Gene rpsI:Gene rpsM:Gene rpsO:Gene rpsQ:Gene rpsT:Gene rrfA:Gene rrfB:Gene rrfC:Gene rrfD:Gene rrfE:Gene rrfF:Gene rrfG:Gene rrfH:Gene rrsA:Gene rrsB:Gene rrsC:Gene rrsD:Gene rrsE:Gene rrsF:Gene rrsG:Gene rrsH:Gene rrlA:Gene rrlB:Gene rrlC:Gene rrlD:Gene rrlE:Gene rrlF:Gene rrlG:Gene rrlH:Gene rsmE:Gene rsmF:Gene rutA:Gene serU:Gene serV:Gene ssrA:Gene trpH:Gene tusB:Gene tusC:Gene tusD:Gene tusE:Gene tyrT:Gene wbbL_1:Gene yedN_1:Gene yeeL_1:Gene yfaS_1:Gene yi82_1:Gene ylbE_2:Gene yjgX_1:Gene </essentialGenes>

Evidence

Add evidence for nonessentiality here:

Gene	Reference(s)	Comments
folA	PMID:8423162
micF	PMID:15466019
rpsF, rpsI, rpsM, rpsO, rpsQ, and rpsT	PMID:7751274
accD, degS, dpiA, dpiB, entD, etk,eutD, eutK, eutM, eutR, eutS, fldA, folD, ftnA, ftnB, ftsN, ftsX, gatA, glcA, gpsA, gsp, hflB, intZ, kup, lolA, lyx, mraY, mreD, mug, murA, murB, murF, nadD, pgmB, pptA, ptrA, purB, qmcA, queC, queF, raiA, ravA, rimN, rlmG, rluE, rluF, rplP, rplV, rpsG, rsmE, rsmF, rutA, trpH	PMID:13129938	accD listed as N*
edit table

Add evidence for essentiality here:

Gene	Reference(s)	Comments
nusA	PMID:17277072
nusE	PMID:17277072
nusG	PMID:17277072
edit table

References

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