coaE:Gene Product(s): Difference between revisions

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!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
dephospho-CoA kinase<ref name='LIB:Riley_2006'/>, B0103<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YacE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CoaE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''dephospho-CoA kinase<ref name='LIB:Riley_2006'/>, B0103<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YacE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, CoaE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0103, JW0100, yacE, b0103''
|-
|-
!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
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* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24]<ref name='LIB:Riley_2006'/>
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24]<ref name='LIB:Riley_2006'/>


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<protect><!--Nomenclature_notes--></protect>
<protect><!--Nomenclature_notes--></protect>
===Notes===
===Notes===
 
''yacE'' is reported to encode dephospho-CoA kinase, which catalyzes the final step of [[wikipedia:Coenzyme A|Coenzyme A]] anabolism.<ref name='PMID:11292795 '/>


==Function==
==Function==
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|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0030288
|
outer membrane-bounded periplasmic space
|
 
|
 
|
 
|
C
|
Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.
|
Missing: evidence, reference
|-  
|-  
|
|


|
|
GO:0015937
GO:0000166
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|
coenzyme A biosynthetic process
nucleotide binding
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|
GO_REF:0000004<br />GO_REF:0000020
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0173<br />HAMAP:MF_00376
SP_KW:KW-0547
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
|
GO:0005737
GO:0005524
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|
cytoplasm
ATP binding
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|
GO_REF:0000004
GOA:hamap<br />GO_REF:0000020
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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SP_KW:KW-0963
HAMAP:MF_00376
|
|
C
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
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complete  
complete  
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|
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GO:0004140
GO:0005524
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|
dephospho-CoA kinase activity
ATP binding
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|
GO_REF:0000003<br />GO_REF:0000020
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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EC:2.7.1.24<br />HAMAP:MF_00376
InterPro:IPR001977
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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ATP binding
ATP binding
|
|
GO_REF:0000002<br />GO_REF:0000004<br />GO_REF:0000020
GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
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|
InterPro:IPR001977<br />SP_KW:KW-0067<br />HAMAP:MF_00376
SP_KW:KW-0067
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F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0000166
GO:0015937
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|
nucleotide binding
coenzyme A biosynthetic process
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|
GO_REF:0000004
GOA:hamap<br />GO_REF:0000020
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0547
HAMAP:MF_00376
|
|
F
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
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complete  
complete  
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GO:0016301
GO:0015937
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|
kinase activity
coenzyme A biosynthetic process
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GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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SP_KW:KW-0418
InterPro:IPR001977
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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|
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GO:0016740
GO:0015937
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|
transferase activity
coenzyme A biosynthetic process
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|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
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IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
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SP_KW:KW-0808
SP_KW:KW-0173
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|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
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dephospho-CoA kinase activity
dephospho-CoA kinase activity
|
|
PMID:11292795
PMID:12538896
|
|
IDA: Inferred from Direct Assay
ISS: Inferred from Sequence or Structural Similarity
|
|
UniProtKB:P44920


|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 
|
|
complete  
complete  
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|
|
GO:0015937
GO:0004140
|
|
coenzyme A biosynthetic process
dephospho-CoA kinase activity
|
|
PMID:11292795
PMID:11292795
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|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
assay of purified recombinant CoaE protein (Table 2 and accompanying text).
|
|
complete  
complete  
|-  
|-  
|
|
 
|
|
GO:0030288
GO:0005829
|
|
outer membrane-bounded periplasmic space
cytosol
|
|
PMID:26602691
|
|
IEA: Inferred from Electronic Annotation
|
|
 
|
|
C  
C
|
|
Seeded from Riley et  al 2006 <ref name='LIB:Riley_2006'/>.  
From EcoCyc_25.5
|
|
required fields missing 
complete


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|- {{table heading style}}
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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
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Protein
|
dps
|


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PMID:19402753
|
LCMS(ID Probability):99.6
|-
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Protein
|
speD
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
 
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!|Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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!align=left {{table heading style}} |Name
||


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YKKANRVLVV DVSPETQLKR TMQRDDVTRE HVEQILAAQA TREARLAVAD DVIDNNGAPD
YKKANRVLVV DVSPETQLKR TMQRDDVTRE HVEQILAAQA TREARLAVAD DVIDNNGAPD
AIASDVARLH AHYLQLASQF VSQEKP</pre>  
AIASDVARLH AHYLQLASQF VSQEKP</pre>  
|-
!align=left {{table heading style}} |Length
||
206
|-
|-
!align=left {{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
22.62 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
22.621 kDa
|-
|-
!align=left {{table heading style}} |pI
!align=left {{table heading style}} |pI
||
||
6.2 (calculated)
|-
|-
!align=left {{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
16960 (calc based on 4 Y, 2 W, and 0 C residues)  
16,960 (calc based on 4 Y, 2 W, and 0 C residues)


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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span>
<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="R46aa1be73aa2b"  class=" tableEdit Product_motif_table dataTable"   
|- {{table heading style}}
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-  
|-  
|
|
Domain
Domain
|
|
4 - 200
3..181
|
[http://pfam.janelia.org/family/PF01121 PF01121  Dephospho-CoA kinase]
|
|
[[interpro:IPR001977|DPCK]]
 
|
|
[http://www.uniprot.org/uniprot/P0A6I9#section_features UniProt:P0A6I9]
PMID:19920124


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<td>
<!-- motifs column 2-->
<motif_map/>
</td>
</tr>
</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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|-
|-
!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>coaE
<beststructure>
562</beststructure>
gene=coaE
 
taxon=562,83333
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=coaE&sub=keywordSearc EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0A6I9 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=coaE&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0A6I9 PSI-PRED (P0A6I9)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0A6I9 Genomes TO Protein (P0A6I9)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
<protect><!--          ***** PLEASE DO NOT EDIT BELOW THIS LINE *****        -->
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===Notes===
===Notes===


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!|Resource type!!Source!!Notes/Reference


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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
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[http://www.ncbi.nlm.nih.gov/protein/16128096 GI:16128096]
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Escherichia coli str. K-12 substr. MG1655
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG12312-MONOMER EcoCyc:EG12312-MONOMER]
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
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[http://www.ncbi.nlm.nih.gov/protein/NP_414645.1 GeneID:949060]
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Escherichia coli str. K-12 substr. MG1655
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[[ASAP]]
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ASAP:ABE-0000357
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.uniprot.org/uniprot/P0A6I9 UniProtKB/Swiss-Prot:P0A6I9]
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Escherichia coli str. K-12 substr. MG1655
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[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
[[EcoCyc]]
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[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1N3B PDB:1N3B]
EcoCyc:EG12312
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
[[EcoGene]]
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[[uniprot:P0A6I9|UniProt:P0A6I9]]
EcoGene:EG12312
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
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[http://pfam.sanger.ac.uk/family?acc=PF01121 PFAM:PF01121]
[http://www.ncbi.nlm.nih.gov/gene?term=949060 GeneID:949060]
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Escherichia coli str. K-12 substr. MG1655
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[RegulonDB]]
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414645 RefSeq:NP_414645]
RegulonDB:ECK120002189
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
[[EchoBASE]]
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[http://salilab.org/modbase/searchbyid?databaseID=P0A6I9 ModBase:P0A6I9]
EchoBASE:EB2218
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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==References==
==References==
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===Categories===
===Categories===
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[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0030288_!_outer membrane-bounded periplasmic space]][[Category:GO:0015937_!_coenzyme A biosynthetic process]][[Category:Products with structures in PDB]]

Latest revision as of 17:55, 15 March 2022

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CoaE

Synonyms

dephospho-CoA kinase[1], B0103[2][1], YacE[2][1], CoaE[2][1] , ECK0103, JW0100, yacE, b0103

Product description

EG12312[2][3]

Dephospho-CoA kinase; final step in CoA synthesis[4]

EC number (for enzymes)
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Notes

yacE is reported to encode dephospho-CoA kinase, which catalyzes the final step of Coenzyme A anabolism.[5]

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030288

outer membrane-bounded periplasmic space

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00376

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001977

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0015937

coenzyme A biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00376

P

Seeded from EcoCyc (v14.0)

complete

GO:0015937

coenzyme A biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001977

P

Seeded from EcoCyc (v14.0)

complete

GO:0015937

coenzyme A biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0173

P

Seeded from EcoCyc (v14.0)

complete

GO:0004140

dephospho-CoA kinase activity

PMID:12538896[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P44920


F

complete

GO:0004140

dephospho-CoA kinase activity

PMID:11292795[5]

IDA: Inferred from Direct Assay

F

assay of purified recombinant CoaE protein (Table 2 and accompanying text).

complete

GO:0005829

cytosol

PMID:26602691[7]

IEA: Inferred from Electronic Annotation

C

From EcoCyc_25.5

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

dps

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

speD

PMID:19402753[8]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MRYIVALTGG IGSGKSTVAN AFADLGINVI DADIIARQVV EPGAPALHAI ADHFGANMIA
ADGTLQRRAL RERIFANPEE KNWLNALLHP LIQQETQHQI QQATSPYVLW VVPLLVENSL
YKKANRVLVV DVSPETQLKR TMQRDDVTRE HVEQILAAQA TREARLAVAD DVIDNNGAPD
AIASDVARLH AHYLQLASQF VSQEKP
Length

206

Mol. Wt

22.621 kDa

pI

6.2 (calculated)

Extinction coefficient

16,960 (calc based on 4 Y, 2 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

3..181

PF01121 Dephospho-CoA kinase

PMID:19920124[9]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=coaE taxon=562,83333 </beststructure>

Models

View models at:

edit table

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128096

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949060

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000357

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6I9

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12312

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12312

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949060

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002189

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2218

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Mishra, P et al. (2001) Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12. J. Bacteriol. 183 2774-8 PubMed
  6. ↑ O'Toole, N et al. (2003) Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli. Protein Sci. 12 327-36 PubMed
  7. ↑ Peabody, MA et al. (2016) PSORTdb: expanding the bacteria and archaea protein subcellular localization database to better reflect diversity in cell envelope structures. Nucleic Acids Res 44 D663-8 PubMed
  8. ↑ 8.0 8.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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