aspA:Gene Product(s): Difference between revisions
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{| | {| id="I46ab1fe783fe7" class=" tableEdit Product_nomenclature_table" | ||
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!align=left {{table heading style}} |Standard name | !align=left {{table heading style}} |Standard name | ||
|| | || | ||
AspA | AspA | ||
|- | |- | ||
!align=left {{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
|| | || | ||
aspartate ammonia-lyase | ''aspartate ammonia-lyase<ref name='LIB:Riley_2006'/>, B4139<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AspA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4133, JW4099, b4139'' | ||
|- | |- | ||
!align=left {{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
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* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.1 4.3.1.1]<ref name='LIB:Riley_2006'/> | * [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.1 4.3.1.1]<ref name='LIB:Riley_2006'/> | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="W46ab1fe993888" class=" tableEdit GO_table_product dataTable" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Qualifier!!GO ID!!GO term name!!Reference | !|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
|- | |- | ||
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catalytic activity | catalytic activity | ||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR000362 | InterPro:IPR000362 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 103: | Line 103: | ||
| | | | ||
GO: | GO:0003824 | ||
| | | | ||
catalytic activity | |||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR008948 | ||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO: | GO:0003824 | ||
| | | | ||
catalytic activity | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR020557 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 141: | Line 141: | ||
| | | | ||
GO: | GO:0005829 | ||
| | | | ||
cytosol | |||
| | | | ||
PMID:16858726 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
C | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO: | GO:0006099 | ||
| | | | ||
tricarboxylic acid cycle | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR018951 | |||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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| | | | ||
GO: | GO:0006531 | ||
| | | | ||
aspartate metabolic process | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR004708 | |||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0008797 | ||
| | | | ||
aspartate ammonia-lyase activity | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR004708 | |||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0008797 | ||
| | | | ||
aspartate ammonia-lyase activity | |||
| | | | ||
GOA:spec<br />GO_REF:0000003 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
EC:4.3.1.1 | |||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
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GO: | GO:0016020 | ||
| | | | ||
membrane | |||
| | | | ||
PMID:16858726 | PMID:16858726 | ||
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C | C | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0016829 | ||
| | | | ||
lyase activity | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR018951 | |||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0016829 | ||
| | | | ||
lyase activity | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
SP_KW:KW-0456 | |||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | |||
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|- {{table heading style}} | |- {{table heading style}} | ||
!|Partner Type!!Partner!!Notes!!References!!Evidence | !|Partner Type!!Partner!!Notes!!References!!Evidence | ||
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Experiment(s):EBI-1147527<br /> | Experiment(s):EBI-1147527<br /> | ||
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|- {{table heading style}} | |- {{table heading style}} | ||
!|Compartment!!Description!!Evidence!!Notes | !|Compartment!!Description!!Evidence!!Reference/Source!!Notes | ||
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{| | {| id="N46ab200acd010" class=" tableEdit Product_phys_prop_table" | ||
|- | |||
!align=left {{table heading style}} |Name | |||
|| | |||
|- | |- | ||
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YNSIGIVTYL NPFIGHHNGD IVGKICAETG KSVREVVLER GLLTEAELDD IFSVQNLMHP | YNSIGIVTYL NPFIGHHNGD IVGKICAETG KSVREVVLER GLLTEAELDD IFSVQNLMHP | ||
AYKAKRYTDE SEQ</pre> | AYKAKRYTDE SEQ</pre> | ||
|- | |||
!align=left {{table heading style}} |Length | |||
|| | |||
493 | |||
|- | |- | ||
!align=left {{table heading style}} |Mol. Wt | !align=left {{table heading style}} |Mol. Wt | ||
|| | || | ||
54.064 kDa | |||
|- | |- | ||
!align=left {{table heading style}} |pI | !align=left {{table heading style}} |pI | ||
|| | || | ||
5.6 (calculated) | |||
|- | |- | ||
!align=left {{table heading style}} |Extinction coefficient | !align=left {{table heading style}} |Extinction coefficient | ||
|| | || | ||
23,840 - 25,340 (calc based on 16 Y, 0 W, and 12 C residues) | |||
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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span> | <span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table> | ||
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|- {{table heading style}} | |- {{table heading style}} | ||
!|Type!!Residues!!Description!!Notes | !|Type!!Residues!!Description!!Notes!!References | ||
|- | |||
| | |||
Domain | |||
| | |||
13..345 | |||
| | |||
[http://pfam.janelia.org/family/PF00206 PF00206 Lyase] | |||
| | |||
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|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28982.X46ab200b4fba1&page=28982&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || | PMID:19920124 | ||
|- | |||
| | |||
Domain | |||
| | |||
411..465 | |||
| | |||
[http://pfam.janelia.org/family/PF10415 PF10415 Fumarase C C-terminus] | |||
| | |||
| | |||
PMID:19920124 | |||
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<td> | |||
<!-- motifs column 2--> | |||
<motif_map/> | |||
</td> | |||
</tr> | |||
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<span id= | <table><tr valign='top'><td> | ||
<span id='Structure'></span><big>'''Structure'''</big><br /> | |||
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!align=left {{table heading style}} |Structures | !align=left {{table heading style}} |Structures | ||
|| | || | ||
<beststructure>aspA | <beststructure> | ||
562</beststructure> | gene=aspA | ||
taxon=562,83333 | |||
</beststructure> | |||
|- | |- | ||
!align=left {{table heading style}} |Models | !align=left {{table heading style}} |Models | ||
|| | || | ||
View models at: | View models at: | ||
* [http:// | * [http://www.proteinmodelportal.org/query/uniprot/P0AC38 Protein Model Portal] | ||
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0AC38 PSI-PRED (P0AC38)] | |||
* [http://bioinf.cs.ucl.ac.uk/ | * [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0AC38 Genomes TO Protein (P0AC38)] (GTOP) | ||
* [http://spock.genes.nig.ac.jp/~genome/ | |||
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==== Structure figures ==== | |||
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===Notes=== | ===Notes=== | ||
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!|Resource type!!Source!!Notes/Reference | !|Resource type!!Source!!Notes/Reference | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="Q46ab200d26c01" class=" tableEdit Gene_accessions_table" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Database!!Accession!!Notes | !|Database!!Accession!!Notes | ||
|- | |- | ||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | ||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/90111690 GI:90111690] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/NP_418562.4 GeneID:948658] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[[ASAP]] | |||
| | | | ||
ASAP:ABE-0013551 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |||
| | |||
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | |||
| | |||
[http://www.uniprot.org/uniprot/P0AC38 UniProtKB/Swiss-Prot:P0AC38] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |- | ||
| | | | ||
[[EcoCyc]] | |||
| | | | ||
EcoCyc:EG10095 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EcoGene]] | |||
| | | | ||
EcoGene:EG10095 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[http://www.ncbi.nlm.nih.gov/ | [http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]]) | ||
| | | | ||
[http://www.ncbi.nlm.nih.gov/ | [http://www.ncbi.nlm.nih.gov/gene?term=948658 GeneID:948658] | ||
| | | | ||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |- | ||
| | | | ||
[[RegulonDB]] | |||
| | | | ||
RegulonDB:ECK120000091 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EchoBASE]] | |||
| | | | ||
EchoBASE:EB0093 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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==References== | ==References== | ||
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<references/> | <references /> | ||
__NOTOC__ | __NOTOC__ | ||
===Categories=== | ===Categories=== | ||
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[[Category:Proteins]] | [[Category:Proteins]] | ||
Latest revision as of 21:13, 17 February 2015
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
AspA |
|---|---|
| Synonyms |
aspartate ammonia-lyase[1], B4139[2][1], AspA[2][1] , ECK4133, JW4099, b4139 |
| Product description |
Component of aspartate ammonia-lyase[2][3] L-Aspartate ammonia-lyase; L-aspartase[4] |
| EC number (for enzymes) | |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003824 |
catalytic activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0003824 |
catalytic activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0003824 |
catalytic activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0006099 |
tricarboxylic acid cycle |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006531 |
aspartate metabolic process |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008797 |
aspartate ammonia-lyase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008797 |
aspartate ammonia-lyase activity |
GOA:spec |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0016829 |
lyase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016829 |
lyase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of aspartate ammonia-lyase |
could be indirect |
||
|
Protein |
dnaK |
Experiment(s):EBI-878610, EBI-881328 | ||
|
Protein |
secA |
Experiment(s):EBI-878610 | ||
|
Protein |
otsB |
Experiment(s):EBI-1147527 | ||
|
Protein |
chbF |
Experiment(s):EBI-1147527 | ||
|
Protein |
nadE |
Experiment(s):EBI-1147527 | ||
|
Protein |
rhsD |
Experiment(s):EBI-1147527 | ||
|
Protein |
carB |
Experiment(s):EBI-1147527 | ||
|
Protein |
yjbI |
Experiment(s):EBI-1147527 | ||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MCLKQIIGSL KKKVHMSNNI RIEEDLLGTR EVPADAYYGV HTLRAIENFY ISNNKISDIP EFVRGMVMVK KAAAMANKEL QTIPKSVANA IIAACDEVLN NGKCMDQFPV DVYQGGAGTS VNMNTNEVLA NIGLELMGHQ KGEYQYLNPN DHVNKCQSTN DAYPTGFRIA VYSSLIKLVD AINQLREGFE RKAVEFQDIL KMGRTQLQDA VPMTLGQEFR AFSILLKEEV KNIQRTAELL LEVNLGATAI GTGLNTPKEY SPLAVKKLAE VTGFPCVPAE DLIEATSDCG AYVMVHGALK RLAVKMSKIC NDLRLLSSGP RAGLNEINLP ELQAGSSIMP AKVNPVVPEV VNQVCFKVIG NDTTVTMAAE AGQLQLNVME PVIGQAMFES VHILTNACYN LLEKCINGIT ANKEVCEGYV YNSIGIVTYL NPFIGHHNGD IVGKICAETG KSVREVVLER GLLTEAELDD IFSVQNLMHP AYKAKRYTDE SEQ |
| Length |
493 |
| Mol. Wt |
54.064 kDa |
| pI |
5.6 (calculated) |
| Extinction coefficient |
23,840 - 25,340 (calc based on 16 Y, 0 W, and 12 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
- ↑ 6.0 6.1 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
- ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories