recQ:Gene Product(s): Difference between revisions
touch the Product_phys_prop_table table. |
touch table |
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****************************************************************************************** -->{{Product_nomenclature_help}} | ****************************************************************************************** -->{{Product_nomenclature_help}} | ||
{| | {| id="J46ab061c861cb" class=" tableEdit Product_nomenclature_table" | ||
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!align=left {{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
|| | || | ||
ATP-dependent DNA helicase<ref name='LIB:Riley_2006'/>, B3822<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecQ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ''ATP-dependent DNA helicase<ref name='LIB:Riley_2006'/>, B3822<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecQ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3816, JW5855, b3822'' | ||
|- | |- | ||
!align=left {{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
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* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.- 3.6.1.-]<ref name='LIB:Riley_2006'/> | * [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.- 3.6.1.-]<ref name='LIB:Riley_2006'/> | ||
|-class= | |- class="tableEdit_footer" | ||
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****************************************************************************************** -->{{Product_GO_help}} | ****************************************************************************************** -->{{Product_GO_help}} | ||
{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="J46ab061da0b94" class=" tableEdit GO_table_product dataTable" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Qualifier!!GO ID!!GO term name!!Reference | !|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0000166 | ||
| | | | ||
nucleotide binding | |||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| Line 92: | Line 92: | ||
InterPro:IPR010997 | InterPro:IPR010997 | ||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 101: | Line 101: | ||
| | | | ||
GO: | GO:0000166 | ||
| | | | ||
nucleotide binding | |||
| | | | ||
GO_REF:0000004 | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0547 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 120: | Line 120: | ||
| | | | ||
GO: | GO:0003676 | ||
| | | | ||
nucleic acid binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR001650 | ||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 139: | Line 139: | ||
| | | | ||
GO: | GO:0003676 | ||
| | | | ||
nucleic acid binding | |||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR002121 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 158: | Line 158: | ||
| | | | ||
GO: | GO:0046914 | ||
| | | | ||
transition metal ion binding | |||
| | | | ||
PMID:2164680 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 177: | Line 177: | ||
| | | | ||
GO: | GO:0003676 | ||
| | | | ||
nucleic acid binding | |||
| | | | ||
GO_REF: | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR011545 | |||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 196: | Line 196: | ||
| | | | ||
GO: | GO:0016887 | ||
| | | | ||
ATPase activity | |||
| | | | ||
PMID:2164680 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | |||
| | | | ||
| | | | ||
complete | complete | ||
| Line 215: | Line 215: | ||
| | | | ||
GO: | GO:0003677 | ||
| | | | ||
DNA | DNA binding | ||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW- | SP_KW:KW-0238 | ||
| | | | ||
F | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 234: | Line 234: | ||
| | | | ||
GO: | GO:0008094 | ||
| | | | ||
DNA-dependent ATPase activity | |||
| | | | ||
PMID:2164680 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | |||
| | | | ||
| | | | ||
complete | complete | ||
| Line 253: | Line 253: | ||
| | | | ||
GO: | GO:0003824 | ||
| | | | ||
catalytic activity | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR010997 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 272: | Line 272: | ||
| | | | ||
GO: | GO:0004003 | ||
| | | | ||
helicase activity | ATP-dependent DNA helicase activity | ||
| | | | ||
PMID:2164680 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 295: | Line 295: | ||
ATP-dependent DNA helicase activity | ATP-dependent DNA helicase activity | ||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| Line 303: | Line 303: | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 310: | Line 310: | ||
| | | | ||
GO: | GO:0005737 | ||
| | | | ||
cytoplasm | |||
| | | | ||
PMID:2164680 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
C | |||
| | | | ||
| | | | ||
complete | complete | ||
| Line 329: | Line 329: | ||
| | | | ||
GO: | GO:0005515 | ||
| | | | ||
protein binding | |||
| | | | ||
PMID:19150358 | |||
| | | | ||
IPI: Inferred from Physical Interaction | |||
| | | | ||
UniProtKB:P0AGE0 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 348: | Line 348: | ||
| | | | ||
GO: | GO:0003677 | ||
| | | | ||
DNA binding | |||
| | | | ||
PMID:14665634 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 367: | Line 367: | ||
| | | | ||
GO: | GO:0005524 | ||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR001650 | ||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0008270 | ||
| | | | ||
zinc ion binding | |||
| | | | ||
PMID:15292213 | |||
| | | | ||
IMP: Inferred from Mutant Phenotype | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 424: | Line 405: | ||
| | | | ||
GO: | GO:0005524 | ||
| | | | ||
ATP binding | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro:IPR011545 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 443: | Line 424: | ||
| | | | ||
GO: | GO:0005524 | ||
| | | | ||
ATP binding | |||
| | | | ||
PMID:15292213 | |||
| | | | ||
IPI: Inferred from Physical Interaction | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
Missing: with/from | |||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0005524 | ||
| | | | ||
ATP binding | |||
| | | | ||
GO_REF: | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0067 | |||
| | | | ||
F | F | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 481: | Line 462: | ||
| | | | ||
GO: | GO:0017116 | ||
| | | | ||
ATP-dependent DNA helicase activity | single-stranded DNA-dependent ATP-dependent DNA helicase activity | ||
| | | | ||
PMID:12805371 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
F | F | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 542: | Line 485: | ||
intracellular | intracellular | ||
| | | | ||
GO_REF:0000002 | GOA:interpro<br />GO_REF:0000002 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| Line 550: | Line 493: | ||
C | C | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 557: | Line 500: | ||
| | | | ||
GO: | GO:0017117 | ||
| | | | ||
DNA | single-stranded DNA-dependent ATP-dependent DNA helicase complex | ||
| | | | ||
PMID:12805371 | |||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
C | |||
| | | | ||
| | | | ||
complete | complete | ||
| Line 576: | Line 519: | ||
| | | | ||
GO: | GO:0006260 | ||
| | | | ||
DNA | DNA replication | ||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR018982 | ||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 595: | Line 538: | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA recombination | |||
| | | | ||
PMID:7868608 | |||
| | | | ||
IMP: Inferred from Mutant Phenotype | |||
| | | | ||
| | | | ||
P | P | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 614: | Line 557: | ||
| | | | ||
GO: | GO:0006281 | ||
| | | | ||
DNA repair | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
InterPro: | InterPro:IPR018982 | ||
| | | | ||
P | |||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
| Line 633: | Line 576: | ||
| | | | ||
GO: | GO:0006281 | ||
| | | | ||
DNA repair | |||
| | | | ||
PMID:7868608 | |||
| | | | ||
IGI: Inferred from Genetic Interaction | |||
| | | | ||
EcoliWiki:recB|EcoliWiki:recC|EcoliWiki:sbcB|EcoliWiki:sbcC | |||
| | | | ||
P | P | ||
| | | | ||
| | | | ||
complete | complete | ||
| Line 671: | Line 595: | ||
| | | | ||
GO: | GO:0006281 | ||
| | | | ||
DNA repair | |||
| | | | ||
GO_REF: | GOA:spkw<br />SP_KW:GO_REF:0000004 | ||
| | | | ||
IEA: Inferred from Electronic Annotation | IEA: Inferred from Electronic Annotation | ||
| | | | ||
SP_KW:KW-0234 | |||
| | | | ||
P | P | ||
| | | | ||
Seeded from EcoCyc | Seeded from [[EcoCyc]] (v14.0) | ||
| | | | ||
complete | complete | ||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0006974 | ||
| | | | ||
response to DNA damage stimulus | |||
| | | | ||
PMID: | PMID:7868608 | ||
| | | | ||
IGI: Inferred from Genetic Interaction | |||
| | | | ||
EcoliWiki:recB|EcoliWiki:recC|EcoliWiki:sbcB|EcoliWiki:sbcC | |||
| | | | ||
P | |||
| | | | ||
| Line 728: | Line 633: | ||
| | | | ||
GO: | GO:0006281 | ||
| | | | ||
DNA repair | |||
| | | | ||
PMID: | PMID:7868608 | ||
| | | | ||
IGI: Inferred from Genetic Interaction | |||
| | | | ||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
Missing: with/from | |||
|- | |- | ||
| | | | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA | DNA recombination | ||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR004589 | |||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 766: | Line 671: | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA recombination | |||
| | | | ||
PMID: | PMID:9553043 | ||
| | | | ||
IDA: Inferred from Direct Assay | IDA: Inferred from Direct Assay | ||
| Line 776: | Line 681: | ||
| | | | ||
P | |||
| | | | ||
With RecA & SSB. | |||
| | | | ||
complete | complete | ||
| Line 785: | Line 690: | ||
| | | | ||
GO: | GO:0005515 | ||
| | | | ||
protein binding | |||
| | | | ||
PMID: | PMID:19150358 | ||
| | | | ||
IPI: Inferred from Physical Interaction | |||
| | | | ||
UniProtKB:P0AGE0 | |||
| | | | ||
F | |||
| | | | ||
SSB (Single-stranded DNA-binding protein) | |||
| | | | ||
complete | complete | ||
| Line 804: | Line 709: | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA | DNA recombination | ||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR006293 | |||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 823: | Line 728: | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA recombination | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR018329 | |||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 842: | Line 747: | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA recombination | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
SP_KW:KW-0233 | |||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 861: | Line 766: | ||
| | | | ||
GO: | GO:0006310 | ||
| | | | ||
DNA recombination | |||
| | | | ||
PMID: | PMID:9553043 | ||
| | | | ||
IDA: Inferred from Direct Assay | IDA: Inferred from Direct Assay | ||
| Line 871: | Line 776: | ||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 880: | Line 785: | ||
| | | | ||
GO: | GO:0009432 | ||
| | | | ||
SOS response | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR006293 | |||
| | | | ||
P | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 899: | Line 804: | ||
| | | | ||
GO: | GO:0009432 | ||
| | | | ||
SOS response | |||
| | | | ||
GOA:spkw<br />SP_KW:GO_REF:0000004 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
SP_KW:KW-0742 | |||
| | | | ||
P | P | ||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 918: | Line 823: | ||
| | | | ||
GO: | GO:0030894 | ||
| | | | ||
replisome | |||
| | | | ||
PMID: | PMID:16385024 | ||
| | | | ||
IDA: Inferred from Direct Assay | |||
| | | | ||
| | | | ||
C | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 937: | Line 842: | ||
| | | | ||
GO: | GO:0043140 | ||
| | | | ||
ATP-dependent 3'-5' DNA helicase activity | |||
| | | | ||
GOA:interpro<br />GO_REF:0000002 | |||
| | | | ||
IEA: Inferred from Electronic Annotation | |||
| | | | ||
InterPro:IPR018982 | |||
| | | | ||
F | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| Line 956: | Line 861: | ||
| | | | ||
GO: | GO:0043590 | ||
| | | | ||
bacterial nucleoid | |||
| | | | ||
PMID: | PMID:16385024 | ||
| | | | ||
IDA: Inferred from Direct Assay | IDA: Inferred from Direct Assay | ||
| Line 966: | Line 871: | ||
| | | | ||
C | |||
| | | | ||
Seeded from [[EcoCyc]] (v14.0) | |||
| | | | ||
complete | complete | ||
| | |- class="tableEdit_footer" | ||
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* | * | ||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="C46ab063c93eed" class=" tableEdit Product_interactions_table dataTable" | ||
|- {{table heading style}} | |- {{table heading style}} | ||
!|Partner Type!!Partner!!Notes!!References!!Evidence | !|Partner Type!!Partner!!Notes!!References!!Evidence | ||
| Line 1,084: | Line 970: | ||
| | | | ||
Experiment(s):EBI-889737<br /> | Experiment(s):EBI-889737<br /> | ||
|- | |||
| | |||
Protein | |||
| | |||
rpmB | |||
| | |||
|-class= | | | ||
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| | |||
LCMS(ID Probability):99.6 | |||
|- | |||
| | |||
Protein | |||
| | |||
topA | |||
| | |||
| | |||
PMID:19402753 | |||
| | |||
LCMS(ID Probability):98.5 MALDI(Z-score):28.250265 | |||
|- | |||
| | |||
Protein | |||
| | |||
ssb | |||
| | |||
| | |||
PMID:19402753 | |||
| | |||
LCMS(ID Probability):99.6 MALDI(Z-score):35.825787 | |||
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!|Compartment!!Description!!Evidence!!Notes | !|Compartment!!Description!!Evidence!!Reference/Source!!Notes | ||
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48,820 - 50,195 (calc based on 18 Y, 4 W, and 11 C residues) | 48,820 - 50,195 (calc based on 18 Y, 4 W, and 11 C residues) | ||
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|- {{table heading style}} | |- {{table heading style}} | ||
!|Type!!Residues!!Description!!Notes | !|Type!!Residues!!Description!!Notes!!References | ||
|- | |||
| | |||
Initiator Methionine | |||
| | |||
1 | |||
| | |||
Removed | |||
| | |||
[http://www.uniprot.org/uniprot/P15043#section_features UniProt:P15043] | |||
| | |||
|- | |- | ||
| | | | ||
Domain | Domain | ||
| | | | ||
27..192 | |||
| | |||
[http://pfam.janelia.org/family/PF00270 PF00270 DEAD/DEAH box helicase] | |||
| | | | ||
| | | | ||
PMID:19920124 | |||
|- | |- | ||
| | | | ||
Domain | Domain | ||
| | | | ||
254..331 | |||
| | |||
[http://pfam.janelia.org/family/PF00271 PF00271 Helicase conserved C-terminal domain] | |||
| | | | ||
| | | | ||
PMID:19920124 | |||
|- | |- | ||
| | | | ||
Domain | Domain | ||
| | | | ||
532..599 | |||
| | | | ||
[ | [http://pfam.janelia.org/family/PF00570 PF00570 HRDC domain] | ||
| | | | ||
|-class= | | | ||
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|- | |||
| | |||
Domain | |||
| | |||
411..514 | |||
| | |||
[http://pfam.janelia.org/family/PF09382 PF09382 RQC domain] | |||
| | |||
| | |||
PMID:19920124 | |||
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<span id= | <table><tr valign='top'><td> | ||
<span id='Structure'></span><big>'''Structure'''</big><br /> | |||
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|- | |- | ||
!align=left {{table heading style}} |Structures | !align=left {{table heading style}} |Structures | ||
|| | || | ||
<beststructure>recQ | <beststructure> | ||
562</beststructure> | gene=recQ | ||
taxon=562,83333 | |||
</beststructure> | |||
|- | |- | ||
!align=left {{table heading style}} |Models | !align=left {{table heading style}} |Models | ||
|| | || | ||
View models at: | View models at: | ||
* [http:// | * [http://www.proteinmodelportal.org/query/uniprot/P15043 Protein Model Portal] | ||
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P15043 PSI-PRED (P15043)] | |||
* [http://bioinf.cs.ucl.ac.uk/ | * [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P15043 Genomes TO Protein (P15043)] (GTOP) | ||
* [http://spock.genes.nig.ac.jp/~genome/ | |||
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<!--Structure_notes--></protect> | </td><td></protect> | ||
==== Structure figures ==== | |||
<protect><!-- ***** PLEASE DO NOT EDIT BELOW THIS LINE ***** --> | |||
</td><tr><table><!--Structure_notes--></protect> | |||
===Notes=== | ===Notes=== | ||
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!|Resource type!!Source!!Notes/Reference | !|Resource type!!Source!!Notes/Reference | ||
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|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Database!!Accession!!Notes | !|Database!!Accession!!Notes | ||
|- | |- | ||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | ||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/162135918 GI:162135918] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/protein/YP_026263.3 GeneID:948318] | ||
| | | | ||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[[ASAP]] | |||
| | |||
ASAP:ABE-0012483 | |||
| | |||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |||
| | |||
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | |||
| | |||
[http://www.uniprot.org/uniprot/P15043 UniProtKB/Swiss-Prot:P15043] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |- | ||
| | | | ||
[[EcoCyc]] | |||
| | | | ||
EcoCyc:EG10833 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EcoGene]] | |||
| | | | ||
EcoGene:EG10833 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[http://www.ncbi.nlm.nih.gov/ | [http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]]) | ||
| | | | ||
[http://www.ncbi.nlm.nih.gov/ | [http://www.ncbi.nlm.nih.gov/gene?term=948318 GeneID:948318] | ||
| | | | ||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |- | ||
| | | | ||
[[RegulonDB]] | |||
| | | | ||
RegulonDB:ECK120000824 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EchoBASE]] | |||
| | | | ||
EchoBASE:EB0826 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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==References== | ==References== | ||
{{BacktoTop}} | {{BacktoTop}} | ||
{{RefHelp}} | |||
<references/> | <references /> | ||
__NOTOC__ | __NOTOC__ | ||
===Categories=== | ===Categories=== | ||
{{BacktoTop}} | {{BacktoTop}} | ||
[[Category:Proteins]] | [[Category:Proteins]] | ||
[[Category: | [[Category:RefGenome_Annotated_Gene]] | ||
Latest revision as of 21:08, 17 February 2015
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
RecQ |
|---|---|
| Synonyms |
ATP-dependent DNA helicase[1], B3822[2][1], RecQ[2][1] , ECK3816, JW5855, b3822 |
| Product description |
ATP-dependent DNA helicase[2][3] DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric[4] |
| EC number (for enzymes) | |
| edit table |
Notes
- A mutant of the human homolog of RecQ, known as BLM, is responsible for Bloom syndrome. See BLM on GONUTS.
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0000166 |
nucleotide binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0003676 |
nucleic acid binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0003676 |
nucleic acid binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0046914 |
transition metal ion binding |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0003676 |
nucleic acid binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016887 |
ATPase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0003677 |
DNA binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008094 |
DNA-dependent ATPase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0003824 |
catalytic activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004003 |
ATP-dependent DNA helicase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0004003 |
ATP-dependent DNA helicase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
complete | ||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0003677 |
DNA binding |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008270 |
zinc ion binding |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
IPI: Inferred from Physical Interaction |
F |
Missing: with/from | ||||
| GO:0005524 |
ATP binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0017116 |
single-stranded DNA-dependent ATP-dependent DNA helicase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0005622 |
intracellular |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0017117 |
single-stranded DNA-dependent ATP-dependent DNA helicase complex |
IDA: Inferred from Direct Assay |
C |
complete | ||||
| GO:0006260 |
DNA replication |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006310 |
DNA recombination |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| GO:0006281 |
DNA repair |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006281 |
DNA repair |
IGI: Inferred from Genetic Interaction |
EcoliWiki:recB|EcoliWiki:recC|EcoliWiki:sbcB|EcoliWiki:sbcC |
P |
complete | |||
| GO:0006281 |
DNA repair |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006974 |
response to DNA damage stimulus |
IGI: Inferred from Genetic Interaction |
EcoliWiki:recB|EcoliWiki:recC|EcoliWiki:sbcB|EcoliWiki:sbcC |
P |
complete | |||
| GO:0006281 |
DNA repair |
IGI: Inferred from Genetic Interaction |
P |
Seeded from EcoCyc (v14.0) |
Missing: with/from | |||
| GO:0006310 |
DNA recombination |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006310 |
DNA recombination |
IDA: Inferred from Direct Assay |
P |
With RecA & SSB. |
complete | |||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
SSB (Single-stranded DNA-binding protein) |
complete | |||
| GO:0006310 |
DNA recombination |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006310 |
DNA recombination |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006310 |
DNA recombination |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006310 |
DNA recombination |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0009432 |
SOS response |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009432 |
SOS response |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0030894 |
replisome |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0043140 |
ATP-dependent 3'-5' DNA helicase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0043590 |
bacterial nucleoid |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
ssb |
Experiment(s):EBI-882208, EBI-885071, EBI-889737 | ||
|
Protein |
aceE |
Experiment(s):EBI-882208 | ||
|
Protein |
aceF |
Experiment(s):EBI-882208, EBI-889737 | ||
|
Protein |
lpdA |
Experiment(s):EBI-882208, EBI-889737 | ||
|
Protein |
topA |
Experiment(s):EBI-882208, EBI-888130 | ||
|
Protein |
rpmB |
Experiment(s):EBI-889737 | ||
|
Protein |
rpsN |
Experiment(s):EBI-889737 | ||
|
Protein |
rpmB |
LCMS(ID Probability):99.6 | ||
|
Protein |
topA |
LCMS(ID Probability):98.5 MALDI(Z-score):28.250265 | ||
|
Protein |
ssb |
LCMS(ID Probability):99.6 MALDI(Z-score):35.825787 | ||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MAQAEVLNLE SGAKQVLQET FGYQQFRPGQ EEIIDTVLSG RDCLVVMPTG GGKSLCYQIP ALLLNGLTVV VSPLISLMKD QVDQLQANGV AAACLNSTQT REQQLEVMTG CRTGQIRLLY IAPERLMLDN FLEHLAHWNP VLLAVDEAHC ISQWGHDFRP EYAALGQLRQ RFPTLPFMAL TATADDTTRQ DIVRLLGLND PLIQISSFDR PNIRYMLMEK FKPLDQLMRY VQEQRGKSGI IYCNSRAKVE DTAARLQSKG ISAAAYHAGL ENNVRADVQE KFQRDDLQIV VATVAFGMGI NKPNVRFVVH FDIPRNIESY YQETGRAGRD GLPAEAMLFY DPADMAWLRR CLEEKPQGQL QDIERHKLNA MGAFAEAQTC RRLVLLNYFG EGRQEPCGNC DICLDPPKQY DGSTDAQIAL STIGRVNQRF GMGYVVEVIR GANNQRIRDY GHDKLKVYGM GRDKSHEHWV SVIRQLIHLG LVTQNIAQHS ALQLTEAARP VLRGESSLQL AVPRIVALKP KAMQKSFGGN YDRKLFAKLR KLRKSIADES NVPPYVVFND ATLIEMAEQM PITASEMLSV NGVGMRKLER FGKPFMALIR AHVDGDDEE |
| Length |
609 |
| Mol. Wt |
68.364 kDa |
| pI |
7.3 (calculated) |
| Extinction coefficient |
48,820 - 50,195 (calc based on 18 Y, 4 W, and 11 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 5.3 5.4 Umezu, K et al. (1990) Escherichia coli RecQ protein is a DNA helicase. Proc. Natl. Acad. Sci. U.S.A. 87 5363-7 PubMed
- ↑ 6.0 6.1 Shereda, RD et al. (2009) Identification of the SSB binding site on E. coli RecQ reveals a conserved surface for binding SSB's C terminus. J. Mol. Biol. 386 612-25 PubMed
- ↑ Dou, SX et al. (2004) The DNA binding properties of the Escherichia coli RecQ helicase. J. Biol. Chem. 279 6354-63 PubMed
- ↑ 8.0 8.1 Liu, JL et al. (2004) The zinc finger motif of Escherichia coli RecQ is implicated in both DNA binding and protein folding. J. Biol. Chem. 279 42794-802 PubMed
- ↑ 9.0 9.1 Xu, HQ et al. (2003) The Escherichia coli RecQ helicase functions as a monomer. J. Biol. Chem. 278 34925-33 PubMed
- ↑ 10.0 10.1 10.2 10.3 Mendonca, VM et al. (1995) DNA helicases in recombination and repair: construction of a delta uvrD delta helD delta recQ mutant deficient in recombination and repair. J. Bacteriol. 177 1326-35 PubMed
- ↑ 11.0 11.1 Harmon, FG & Kowalczykowski, SC (1998) RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination. Genes Dev. 12 1134-44 PubMed
- ↑ 12.0 12.1 Sanchez, H et al. (2006) Recruitment of Bacillus subtilis RecN to DNA double-strand breaks in the absence of DNA end processing. J. Bacteriol. 188 353-60 PubMed
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
- ↑ 14.0 14.1 14.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
- ↑ 15.0 15.1 15.2 15.3 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0000166 ! nucleotide binding
- GO:0003676 ! nucleic acid binding
- GO:0046914 ! transition metal ion binding
- GO:0016887 ! ATPase activity
- GO:0003677 ! DNA binding
- GO:0008094 ! DNA-dependent ATPase activity
- GO:0003824 ! catalytic activity
- GO:0004003 ! ATP-dependent DNA helicase activity
- GO:0005737 ! cytoplasm
- GO:0005515 ! protein binding
- GO:0005524 ! ATP binding
- GO:0008270 ! zinc ion binding
- GO:0017116 ! single-stranded DNA-dependent ATP-dependent DNA helicase activity
- GO:0005622 ! intracellular
- GO:0017117 ! single-stranded DNA-dependent ATP-dependent DNA helicase complex
- GO:0006260 ! DNA replication
- GO:0006310 ! DNA recombination
- GO:0006281 ! DNA repair
- GO:0006974 ! cellular response to DNA damage stimulus
- GO:0009432 ! SOS response
- GO:0030894 ! replisome
- GO:0043140 ! ATP-dependent 3'-5' DNA helicase activity
- GO:0043590 ! bacterial nucleoid
- Proteins
- RefGenome Annotated Gene