prs:Gene Product(s): Difference between revisions

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*  
*  
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****************************************************************************************** -->{{Product_nomenclature_help}}
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!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
phosphoribosylpyrophosphate synthase<ref name='LIB:Riley_2006'/>, B1207<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Prs<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PrsA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''phosphoribosylpyrophosphate synthase<ref name='LIB:Riley_2006'/>, B1207<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Prs<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PrsA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dnaR, ECK1195, JW1198, prsA, b1207''
|-
|-
!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
Line 55: Line 55:
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1]<ref name='LIB:Riley_2006'/>
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1]<ref name='LIB:Riley_2006'/>


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*  
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****************************************************************************************** -->{{Product_GO_help}}
****************************************************************************************** -->{{Product_GO_help}}
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="E46aa5c4f146a5"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-  
|-  
|
|


|
|
GO:0005515
GO:0000166
|
|
protein binding
nucleotide binding
|
|
PMID:16606699
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0A6F5
SP_KW:KW-0547
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 100: Line 100:


|
|
GO:0005515
GO:0000287
|
|
protein binding
magnesium ion binding
|
|
PMID:16606699
GOA:hamap<br />GO_REF:0000020
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0A7D1
HAMAP:MF_00583
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 119: Line 119:


|
|
GO:0005515
GO:0000287
|
|
protein binding
magnesium ion binding
|
|
PMID:16606699
GOA:interpro<br />GO_REF:0000002
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0A9Q1
InterPro:IPR000842
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 138: Line 138:


|
|
GO:0005515
GO:0000287
|
|
protein binding
magnesium ion binding
|
|
PMID:16606699
GOA:interpro<br />GO_REF:0000002
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0A9T6
InterPro:IPR005946
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 157: Line 157:


|
|
GO:0005515
GO:0000287
|
|
protein binding
magnesium ion binding
|
|
PMID:16606699
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P0AF63
SP_KW:KW-0460
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 176: Line 176:


|
|
GO:0005515
GO:0004749
|
|
protein binding
ribose phosphate diphosphokinase activity
|
|
PMID:16606699
GOA:hamap<br />GO_REF:0000020
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P13458
HAMAP:MF_00583
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 195: Line 195:


|
|
GO:0005515
GO:0004749
|
|
protein binding
ribose phosphate diphosphokinase activity
|
|
PMID:16606699
GOA:interpro<br />GO_REF:0000002
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P36767
InterPro:IPR000842
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 214: Line 214:


|
|
GO:0005515
GO:0004749
|
|
protein binding
ribose phosphate diphosphokinase activity
|
|
PMID:16606699
GOA:interpro<br />GO_REF:0000002
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P39176
InterPro:IPR005946
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 233: Line 233:


|
|
GO:0005515
GO:0004749
|
|
protein binding
ribose phosphate diphosphokinase activity
|
|
PMID:16606699
GOA:spec<br />GO_REF:0000003
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:P60390
EC:2.7.6.1
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 252: Line 252:


|
|
GO:0005515
GO:0005524
|
|
protein binding
ATP binding
|
|
PMID:16606699
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IPI: Inferred from Physical Interaction
IEA: Inferred from Electronic Annotation
|
|
UniProtKB:Q47005
SP_KW:KW-0067
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0005515
|
protein binding
|
PMID:16606699
|
IPI: Inferred from Physical Interaction
|
UniProtKB:Q47156
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
|
complete  
complete  
Line 294: Line 275:
cytoplasm
cytoplasm
|
|
PMID:16858726
GOA:hamap<br />GO_REF:0000020
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
HAMAP:MF_00583
|
|
C
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 309: Line 290:


|
|
GO:0046872
GO:0005737
|
|
metal ion binding
cytoplasm
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0479
SP_KW:KW-0963
|
|
F
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 328: Line 309:


|
|
GO:0016740
GO:0005737
|
|
transferase activity
cytoplasm
|
|
GO_REF:0000004
GO_REF:0000023
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0808
SP_SL:SL-0086
|
|
F
C
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 347: Line 328:


|
|
GO:0016301
GO:0009116
|
|
kinase activity
nucleoside metabolic process
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0418
InterPro:IPR000836
|
|
F
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 366: Line 347:


|
|
GO:0009165
GO:0009156
|
|
nucleotide biosynthetic process
ribonucleoside monophosphate biosynthetic process
|
|
GO_REF:0000002<br />GO_REF:0000004
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR005946<br />SP_KW:KW-0545
HAMAP:MF_00583
|
|
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 389: Line 370:
ribonucleoside monophosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
|
|
GO_REF:0000002<br />GO_REF:0000020
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000842<br />HAMAP:MF_00583
InterPro:IPR000842
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 404: Line 385:


|
|
GO:0009116
GO:0009165
|
|
nucleoside metabolic process
nucleotide biosynthetic process
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000836
InterPro:IPR005946
|
|
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 423: Line 404:


|
|
GO:0005737
GO:0009165
|
|
cytoplasm
nucleotide biosynthetic process
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0963
SP_KW:KW-0545
|
|
C
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 442: Line 423:


|
|
GO:0004749
GO:0016301
|
|
ribose phosphate diphosphokinase activity
kinase activity
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000003<br />GO_REF:0000020
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000842<br />InterPro:IPR005946<br />EC:2.7.6.1<br />HAMAP:MF_00583
SP_KW:KW-0418
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 461: Line 442:


|
|
GO:0000287
GO:0016740
|
|
magnesium ion binding
transferase activity
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004<br />GO_REF:0000020
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000842<br />InterPro:IPR005946<br />SP_KW:KW-0460<br />HAMAP:MF_00583
SP_KW:KW-0808
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 480: Line 461:


|
|
GO:0044249
GO:0046872
|
|
cellular biosynthetic process
metal ion binding
|
|
GO_REF:0000002
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000842
SP_KW:KW-0479
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|
 
|
GO:0000287
|
magnesium ion binding
|
GO_REF:0000020<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00583<br />InterPro:IPR000842<br />InterPro:IPR005946<br />SP_KW:KW-0460
|
F
|
Seeded from EcoCyc
|
complete
|-
|
 
|
GO:0004749
|
ribose phosphate diphosphokinase activity
|
GO_REF:0000020<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000003
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00583<br />InterPro:IPR000842<br />InterPro:IPR005946<br />EC:2.7.6.1
|
|
F
F
|
|
Seeded from EcoCyc
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-
|
|
GO:0009152
|
purine ribonucleotide biosynthetic process
|
|
|
|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing 
|-
|


|
|- class="tableEdit_footer"
GO:0005515
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22344.E46aa5c4f146a5&page=22344&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</span> || || || || || || || ||
|
protein binding
|
PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699<br />PMID:16606699
|
IPI: Inferred from Physical Interaction
|
UniProtKB:P0A6F5<br />UniProtKB:P0A7D1<br />UniProtKB:P0A9Q1<br />UniProtKB:P0A9T6<br />UniProtKB:P0AF63<br />UniProtKB:P13458<br />UniProtKB:P36767<br />UniProtKB:P39176<br />UniProtKB:P60390<br />UniProtKB:Q47005<br />UniProtKB:Q47156
|
F
|
Seeded from EcoCyc
|
complete
 
|-class='sortbottom'
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="P46aa5c563787c"  class=" tableEdit Product_interactions_table dataTable"   
|- {{table heading style}}
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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
Line 1,028: Line 933:
|
|
Experiment(s):EBI-1139177<br />  
Experiment(s):EBI-1139177<br />  
|-
|
Protein
|
groL
|
|
PMID:19402753
|
LCMS(ID Probability):99.6 MALDI(Z-score):17.053160
|-
|
Protein
|
groS
|
|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
rplP
|
|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
tufB
|
|
PMID:19402753
|
MALDI(Z-score):19.993235
|-
|
Protein
|
rplB
|
|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
rpsD
|


|-class='sortbottom'
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PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
rpsC
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
clpA
|
 
|
PMID:19402753
|
MALDI(Z-score):22.990623
|-
|
Protein
|
dnaJ
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
srmB
|
 
|
PMID:19402753
|
MALDI(Z-score):27.524038
|-
|
Protein
|
rluB
|
 
|
PMID:19402753
|
LCMS(ID Probability):90.0 MALDI(Z-score):36.244522
|-
|
Protein
|
recE
|
 
|
PMID:19402753
|
MALDI(Z-score):28.522026
|-
|
Protein
|
cobB
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):37.808327
|-
|
Protein
|
lpxB
|
 
|
PMID:19402753
|
MALDI(Z-score):37.191021
|-
|
Protein
|
hofM
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.0
 
|- class="tableEdit_footer"
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|- {{table heading style}}
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!|Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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!align=left {{table heading style}} |Name
||


|-
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!align=left {{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Mol. Wt
||
||
34.22 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
34.218 kDa
|-
|-
!align=left {{table heading style}} |pI
!align=left {{table heading style}} |pI
||
||
5.52<ref name='LIB:EcoCyc10.6'/>
5.2 (calculated)
|-
|-
!align=left {{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |Extinction coefficient
||
||
5960 - 6460 (calc based on 4 Y, 0 W, and 4 C residues)  
5,960 - 6,460 (calc based on 4 Y, 0 W, and 4 C residues)


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|- {{table heading style}}
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!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-
|
Initiator Methionine
|
1
|
Removed
|
[http://www.uniprot.org/uniprot/P0A717#section_features UniProt:P0A717]
|
|-
|
Domain
|
149..250
|
[http://pfam.janelia.org/family/PF00156 PF00156  Phosphoribosyl transferase domain]
|
 
|
PMID:19920124


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</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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{|   id="T46a7ef35b8bd3" class=" tableEdit Product_structure_table"


|-
|-
!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>prs
<beststructure>
562</beststructure>
gene=prs
 
taxon=562,83333
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=prs&sub=keywordSearc EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0A717 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=prs&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0A717 PSI-PRED (P0A717)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0A717 Genomes TO Protein (P0A717)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===


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|- {{table_heading_style}}
|- {{table_heading_style}}
!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-  
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PRPPSYN-MONOMER EcoCyc:PRPPSYN-MONOMER]
[http://www.ncbi.nlm.nih.gov/protein/16129170 GI:16129170]
|
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415725.1 GeneID:945772]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0004054
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0A717 UniProtKB/Swiss-Prot:P0A717]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[EcoCyc]]
|
EcoCyc:EG10774
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
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|
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
[[EcoGene]]
|
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0A717 SwissModel:P0A717]
EcoGene:EG10774
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|-  
|
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[[uniprot:P0A717|UniProt:P0A717]]
[http://www.ncbi.nlm.nih.gov/gene?term=945772 GeneID:945772]
|
|
Escherichia coli str. K-12 substr. MG1655
|-  
|-  
|
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://pfam.sanger.ac.uk/family?acc=PF00156 PFAM:PF00156]
RegulonDB:ECK120000765
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
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|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415725 RefSeq:NP_415725]
EchoBASE:EB0767
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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!|Name!!URL!!Comments
!|Name!!URL!!Comments


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==References==
==References==
{{BacktoTop}}
{{BacktoTop}}
 
{{RefHelp}}
<references/>
<references />
__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0009152_!_purine ribonucleotide biosynthetic process]]
[[Category:Proteins]]

Latest revision as of 20:35, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PrsA

Synonyms

phosphoribosylpyrophosphate synthase[1], B1207[2][1], DnaR[2][1], Prs[2][1], PrsA[2][1] , dnaR, ECK1195, JW1198, prsA, b1207

Product description

Phosphoribosylpyrophosphate synthase[3]

EC number (for enzymes)


Notes

Function

[back to top]


Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000842

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005946

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000842

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005946

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.6.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0009116

nucleoside metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000836

P

Seeded from EcoCyc (v14.0)

complete

GO:0009156

ribonucleoside monophosphate biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

P

Seeded from EcoCyc (v14.0)

complete

GO:0009156

ribonucleoside monophosphate biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000842

P

Seeded from EcoCyc (v14.0)

complete

GO:0009165

nucleotide biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005946

P

Seeded from EcoCyc (v14.0)

complete

GO:0009165

nucleotide biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0545

P

Seeded from EcoCyc (v14.0)

complete

GO:0016301

kinase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

npdA

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-881344, EBI-885898

Protein

dnaJ

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

dnaK

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

groL

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

mreB

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

rplB

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rplE

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

rplJ

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

rplP

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsB

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsC

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsD

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsG

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

tufA

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rluB

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

yibA

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

nusG

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rho

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplC

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplD

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplI

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplK

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplL

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplM

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplN

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplO

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplS

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplU

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplV

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplW

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplX

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpmB

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsE

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsH

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsJ

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsP

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsT

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

yfiF

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

yrfD

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

groL

PMID:16606699[5]

Experiment(s):EBI-1139177

Protein

groL

PMID:19402753[6]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

groS

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

rplP

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

tufB

PMID:19402753[6]

MALDI(Z-score):19.993235

Protein

rplB

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

rpsD

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

rpsC

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

clpA

PMID:19402753[6]

MALDI(Z-score):22.990623

Protein

dnaJ

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

srmB

PMID:19402753[6]

MALDI(Z-score):27.524038

Protein

rluB

PMID:19402753[6]

LCMS(ID Probability):90.0 MALDI(Z-score):36.244522

Protein

recE

PMID:19402753[6]

MALDI(Z-score):28.522026

Protein

cobB

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):37.808327

Protein

lpxB

PMID:19402753[6]

MALDI(Z-score):37.191021

Protein

hofM

PMID:19402753[6]

LCMS(ID Probability):99.0


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes


Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MPDMKLFAGN ATPELAQRIA NRLYTSLGDA AVGRFSDGEV SVQINENVRG GDIFIIQSTC
APTNDNLMEL VVMVDALRRA SAGRITAVIP YFGYARQDRR VRSARVPITA KVVADFLSSV
GVDRVLTVDL HAEQIQGFFD VPVDNVFGSP ILLEDMLQLN LDNPIVVSPD IGGVVRARAI
AKLLNDTDMA IIDKRRPRAN VSQVMHIIGD VAGRDCVLVD DMIDTGGTLC KAAEALKERG
AKRVFAYATH PIFSGNAANN LRNSVIDEVV VCDTIPLSDE IKSLPNVRTL TLSGMLAEAI
RRISNEESIS AMFEH
Length

315

Mol. Wt

34.218 kDa

pI

5.2 (calculated)

Extinction coefficient

5,960 - 6,460 (calc based on 4 Y, 0 W, and 4 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A717

Domain

149..250

PF00156 Phosphoribosyl transferase domain

PMID:19920124[7]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=prs taxon=562,83333 </beststructure>

Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference


Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129170

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945772

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004054

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A717

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10774

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10774

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945772

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000765

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0767

Escherichia coli str. K-12 substr. MG1655


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  5. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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