Phage lambda cI:Gene Product(s): Difference between revisions

From EcoliWiki
Jump to navigation Jump to search
← Older edit
No edit summary
touch table
 
(27 intermediate revisions by 5 users not shown)
Line 31: Line 31:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_nomenclature_help}}
{|{{Prettytable}}
{|  class=" tableEdit Product_nomenclature_table" 
 
|-
|-
!{{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
|
||
cI  
cI
|-
|-
!{{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
|
||
cI, lambdap88  
cI, lambdap88
|-
|-
!{{table heading style}} |Product description
!align=left {{table heading style}} |Product description
|
||
repressor  
repressor
|-
|-
!{{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
|
||
 


|-
|- class="tableEdit_footer"
|colspan='2'|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..X46b16f6f73bca&page=&pagename={{FULLPAGENAMEE}} edit table]
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..X46b16f6f73bca&page=104187&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table]</span> ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..X46b16f6f73bca-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..X46b16f6f73bca-->
Line 68: Line 70:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_GO_help}}
{|class = 'sortable' {{Prettytable}} id='94552'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  class=" tableEdit GO_table_product dataTable" 
|- {{table_heading_style}}
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-class='sortbottom'
|-
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..P46a3f5de98840&page=&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|
 
|
GO:0004175
|
endopeptidase activity
|
PMID:14733611
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0097264
|
self proteolysis
|
PMID:14733611
|
IDA: Inferred from Direct Assay
|
 
|
P
|
 
|
complete
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..P46a3f5de98840&page=104187&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_product edit table]</span> || || || || || || || ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..P46a3f5de98840-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..P46a3f5de98840-->




<span id="Interactions"></span><big>'''Interactions'''</big>
<span id="Interactions"></span><big>'''Interactions '''</big>
<protect><!--box uid=bc145ea147f7e36caf09c1bfeed4ee9d.104187.D4a848f7275feb-->
<!--
******************************************************************************************
*
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*
****************************************************************************************** -->{{Product_interactions_help}}
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="D4a848f7275feb"  class=" tableEdit Product_interactions_table dataTable" 
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.104187.D4a848f7275feb&page=104187&pagename={{FULLPAGENAMEE}}&type=0&template=Product_interactions_table edit table]</span> || || || ||
|}
<!--box uid=bc145ea147f7e36caf09c1bfeed4ee9d.104187.D4a848f7275feb--></protect>




<!--Function_notes--></protect>
<!--Function_notes-->
===Notes===
===Notes===


Line 92: Line 148:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_localization_help}}
{|class = 'sortable' {{Prettytable}} id='94554'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  class=" tableEdit Product_localization_table" 
|- {{table heading style}}
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-class='sortbottom'
 
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..I46a3f98972f0d&page=&pagename={{FULLPAGENAMEE}} edit table] || || ||
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..I46a3f98972f0d&page=104187&pagename={{FULLPAGENAMEE}}&type=0&template=Product_localization_table edit table]</span> || || || ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..I46a3f98972f0d-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..I46a3f98972f0d-->
Line 116: Line 173:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_physical_properties_help}}
{|{{Prettytable}}
{|  class=" tableEdit Product_phys_prop_table" 
 
|-
|-
!{{table heading style}} |Sequence
!align=left {{table heading style}} |Name
|
||


|-
!align=left {{table heading style}} |Sequence
||
<pre>MSTKKKPLTQ EQLEDARRLK AIYEKKKNEL GLSQESVADK MGMGQSGVGA LFNGINALNA
<pre>MSTKKKPLTQ EQLEDARRLK AIYEKKKNEL GLSQESVADK MGMGQSGVGA LFNGINALNA
YNAALLAKIL KVSVEEFSPS IAREIYEMYE AVSMQPSLRS EYEYPVFSHV QAGMFSPELR
YNAALLAKIL KVSVEEFSPS IAREIYEMYE AVSMQPSLRS EYEYPVFSHV QAGMFSPELR
TFTKGDAERW VSTTKKASDS AFWLEVEGNS MTAPTGSKPS FPDGMLILVD PEQAVEPGDF
TFTKGDAERW VSTTKKASDS AFWLEVEGNS MTAPTGSKPS FPDGMLILVD PEQAVEPGDF
CIARLGGDEF TFKKLIRDSG QVFLQPLNPQ YPMIPCNESC SVVGKVIASQ WPEETFG</pre>  
CIARLGGDEF TFKKLIRDSG QVFLQPLNPQ YPMIPCNESC SVVGKVIASQ WPEETFG</pre>
|-
|-
!{{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Length
|
||
26.21 kDa (calc) 
237
|-
|-
!{{table heading style}} |pI
!align=left {{table heading style}} |Mol. Wt
|
||
26.211 kDa
|-
|-
!{{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |pI
|
||
4.9 (calculated)
|-
|-
|colspan='2'|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..Q46a403a7cbcc2&page=&pagename={{FULLPAGENAMEE}} edit table]
!align=left {{table heading style}} |Extinction coefficient
||
26,930 - 27,305 (calc based on 7 Y, 3 W, and 3 C residues)
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..Q46a403a7cbcc2&page=104187&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table]</span> ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..Q46a403a7cbcc2-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..Q46a403a7cbcc2-->




<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span>
<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
<!--box uid=421aa90e079fa326b6494f812ad13e79..D46a403a8088eb-->
<tr align="left" valign="top">
<td><!--box uid=421aa90e079fa326b6494f812ad13e79..D46a403a8088eb-->
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_domains_motifs_help}}
{|class = 'sortable' {{Prettytable}} id='94556'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  class=" tableEdit Product_motif_table dataTable" 
|- {{table heading style}}
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-class='sortbottom'
|-
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..D46a403a8088eb&page=&pagename={{FULLPAGENAMEE}} edit table] || || ||
|
Domain
|
19 - 77
|
[[interpro:IPR000655|HTH cro/C1-type]]
|
[http://www.uniprot.org/uniprot/P03034#section_features UniProt:P03034]
|
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..D46a403a8088eb&page=104187&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..D46a403a8088eb-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..D46a403a8088eb--></td>
 
<td>
 
<!-- motifs column 2-->
<span id="Structure"></span><big>'''Structure'''</big>
{{Image:3BDN.pdb}}
<motif_map/>
</td>
</tr>
</table>


{{Something New|A new Structure table. <br />We are currently working on reformatting the table to provide more information and references to structures and computational models. We would love to add your research here! If you are interested in adding your data, contact [[User:DanielRenfro|Daniel]]. You can find our [[http://ecoliwiki.net/tools/PDB_Table/index.php?page_title={{PAGENAMEE}} Blast results here]].}}
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />


<!--box uid=421aa90e079fa326b6494f812ad13e79..S46a403a83898d-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..S46a403a83898d-->
Line 176: Line 259:
*  
*  
****************************************************************************************** -->{{Product_structure_help}}
****************************************************************************************** -->{{Product_structure_help}}
{|border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" {{Prettytable}}
{| {{Prettytable}} class=" tableEdit Product_structure_table" 


|-
|-
!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
||
X-ray
<beststructure>
||
gene=Phage_lambda_cI
X-ray
taxon=10710
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
lambda
View models at:
||
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
 
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


|-class='sortbottom'
|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..S46a403a83898d&page=104187&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] || ||
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..S46a403a83898d&page=104187&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table]</span> ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..S46a403a83898d-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..S46a403a83898d-->


<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
{{Image:3BDN.pdb}}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
<protect><!--          ***** PLEASE DO NOT EDIT BELOW THIS LINE *****        -->
</td><tr><table><!--Structure_notes--></protect>
===Notes===
===Notes===
Lambda repressor consists of an [[Phage lambda cI:Gene Product(s)/N-domain|N-terminal DNA binding domain]] and a C-terminal oligomerization domain, connected by a flexible linker.  The N-terminal domain in isolation dimerizes weakly through helix 5-helix 5 contacts.  The C-terminal domain is required for dimerization and DNA binding at normal in vivo expression levels.  Induction of phage lambda by the SOS response involves autoproteolysis at a specific site in the linker by the C-domain.
Lambda repressor consists of an [[Phage lambda cI:Gene Product(s)/N-domain|N-terminal DNA binding domain]] and a C-terminal oligomerization domain, connected by a flexible linker.  The N-terminal domain in isolation dimerizes weakly through helix 5-helix 5 contacts.  The C-terminal domain is required for dimerization and DNA binding at normal in vivo expression levels.  Induction of phage lambda by the SOS response involves autoproteolysis at a specific site in the linker by the C-domain.
Line 205: Line 310:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_resources_help}}
{|class = 'sortable' {{Prettytable}} id='94558'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  class=" tableEdit Product_resource_table" 
|- {{table_heading_style}}
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference
|-class='sortbottom'
 
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..F46a40fd0a727b&page=&pagename={{FULLPAGENAMEE}} edit table] || ||
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..F46a40fd0a727b&page=104187&pagename={{FULLPAGENAMEE}}&type=0&template=Product_resource_table edit table]</span> || ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..F46a40fd0a727b-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..F46a40fd0a727b-->
Line 226: Line 332:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Gene_accessions_help}}
{|class = 'sortable' {{Prettytable}} id='95037'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  class=" tableEdit Gene_accessions_table" 
|- {{table_heading_style}}
|- {{table_heading_style}}
!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
 
|
|- class="tableEdit_footer"
[http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene Genbank] ([[Genbank|EcoliWiki Page]])
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..E46a416276fe4e&page=104187&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table]</span> || ||
|
[http://www.ncbi.nlm.nih.gov/sites/entrez?db=protein&cmd=&term=NP_040628.1 Genbank:NP_040628.1] 
|
|-class='sortbottom'
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..E46a416276fe4e&page=&pagename={{FULLPAGENAMEE}} edit table] || ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..E46a416276fe4e-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..E46a416276fe4e-->
Line 254: Line 354:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->
{|class = 'sortable' {{Prettytable}} id='218644'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  class=" tableEdit Links_table" 
|- {{table_heading_style}}
|- {{table_heading_style}}
!Name!!URL!!Comments
!|Name!!URL!!Comments
|-class='sortbottom'
 
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..R46b16f76208c3&page=&pagename={{FULLPAGENAMEE}} edit table] || ||
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79..R46b16f76208c3&page=104187&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table]</span> || ||
|}
|}
<!--box uid=421aa90e079fa326b6494f812ad13e79..R46b16f76208c3-->
<!--box uid=421aa90e079fa326b6494f812ad13e79..R46b16f76208c3-->
Line 272: Line 373:
==References==
==References==
{{BacktoTop}}
{{BacktoTop}}
 
{{RefHelp}}
<references/>
<references />
__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}

Latest revision as of 20:19, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

cI

Synonyms

cI, lambdap88

Product description

repressor

EC number (for enzymes)


edit table


Notes

Function

[back to top]


Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004175

endopeptidase activity

PMID:14733611[1]

IDA: Inferred from Direct Assay

F

complete

GO:0097264

self proteolysis

PMID:14733611[1]

IDA: Inferred from Direct Assay

P

complete

edit table


Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
edit table


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
edit table


Notes

Structure and Physical Properties

[back to top]


Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MSTKKKPLTQ EQLEDARRLK AIYEKKKNEL GLSQESVADK MGMGQSGVGA LFNGINALNA
YNAALLAKIL KVSVEEFSPS IAREIYEMYE AVSMQPSLRS EYEYPVFSHV QAGMFSPELR
TFTKGDAERW VSTTKKASDS AFWLEVEGNS MTAPTGSKPS FPDGMLILVD PEQAVEPGDF
CIARLGGDEF TFKKLIRDSG QVFLQPLNPQ YPMIPCNESC SVVGKVIASQ WPEETFG
Length

237

Mol. Wt

26.211 kDa

pI

4.9 (calculated)

Extinction coefficient

26,930 - 27,305 (calc based on 7 Y, 3 W, and 3 C residues)

edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

19 - 77

HTH cro/C1-type

UniProt:P03034


edit table

<motif_map/>

Structure

See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=Phage_lambda_cI taxon=10710 </beststructure>

Models

View models at:

edit table

Structure figures

See Help:Jmol in EcoliWiki

full length lambda repressor bound to operator DNA
<jmol> <jmolApplet> <color>white</color> <uploadedFileContents >3BDN.pdb</uploadedFileContents> <script> wireframe off; spacefill off; trace off; reset;center {11.954998 19.6415 35.014}; rotate z 95.96; rotate y 86.35; rotate z 117.3; cartoon; select protein; color chain; </script> </jmolApplet> </jmol>
<jmol> <jmolCheckbox > <scriptWhenChecked > rotate on; </scriptWhenChecked > <scriptWhenUnchecked > rotate off; </scriptWhenUnchecked > <checked>false</checked> <text>rotate</text> </jmolCheckbox > <jmolButton><script>reset; reset;center {11.954998 19.6415 35.014}; rotate z 95.96; rotate y 86.35; rotate z 117.3; cartoon; select protein; color chain; </script><text>reset</text></jmolButton> </jmol>









Notes

Lambda repressor consists of an N-terminal DNA binding domain and a C-terminal oligomerization domain, connected by a flexible linker. The N-terminal domain in isolation dimerizes weakly through helix 5-helix 5 contacts. The C-terminal domain is required for dimerization and DNA binding at normal in vivo expression levels. Induction of phage lambda by the SOS response involves autoproteolysis at a specific site in the linker by the C-domain.

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table


Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
edit table


Notes

Links

[back to top]


Name URL Comments
edit table



References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 Ghosh, K et al. (2004) pH-dependent autocleavage of lambda repressor occurs in the operator-bound form: characterization of lambda repressor autocleavage. Biochem. J. 379 325-30 PubMed

Categories

[back to top]


Retrieved from "https://ecoliwiki.org/colipedia/index.php?title=Phage_lambda_cI:Gene_Product(s)&oldid=1492041"