zntR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ZntR

Synonyms

DNA-binding transcriptional activator in response to Zn(II)[1], B3292[2][1], YhdM[2][1], ZntR[2][1] , ECK3279, JW3254, yhdM, b3292

Product description

ZntR transcriptional regulator[2]; ZntR transcriptional activator[3]

Zn-responsive activator of zntA transcription[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009061

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000551

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:10048032[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:8063098[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P22853
UniProtKB:Q56287
UniProtKB:Q7BT49

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:10048032[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:8063098[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P22853
UniProtKB:Q56287
UniProtKB:Q7BT49

F

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:10048032[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:8063098[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P22853
UniProtKB:Q56287
UniProtKB:Q7BT49

P

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MYRIGELAKM AEVTPDTIRY YEKQQMMEHE VRTEGGFRLY TESDLQRLKF IRHARQLGFS
LESIRELLSI RIDPEHHTCQ ESKGIVQERL QEVEARIAEL QSMQRSLQRL NDACCGTAHS
SVYCSILEAL EQGASGVKSG C
Length

141

Mol. Wt

16.178 kDa

pI

6.4 (calculated)

Extinction coefficient

7,450 - 8,075 (calc based on 5 Y, 0 W, and 5 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

3..40

PF00376 MerR family regulatory protein

PMID:19920124[7]

Domain

45..110

PF09278 MerR, DNA binding

PMID:19920124[7]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=zntR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131171

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947786

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010793

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ACS5

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11969

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11969

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947786

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001894

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1912

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 Brocklehurst, KR et al. (1999) ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli. Mol. Microbiol. 31 893-902 PubMed
  6. 6.0 6.1 6.2 Christie, GE et al. (1994) A merR homologue at 74 minutes on the Escherichia coli genome. Gene 146 131-2 PubMed
  7. 7.0 7.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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