yajL:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
YajL |
|---|---|
| Synonyms |
conserved protein[1], B0424[2][1], YajL[2][1], ThiJ[2][1] , ECK0418, JW5057, thiJ, b0424 |
| Product description |
Function unknown, PfpI/HchA protease/chaperone family; not involved in thiamine metabolism[4] |
| EC number (for enzymes) |
|
| edit table |
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Notes
"YajL was mistakenly identified as ThiJ and was implicated in thiamine biosynthesis. However, later experiments showed that the original complementation phenotype was due to the neighboring gene, thiI [5]. The biochemical function of YajL is therefore unclear." (from EcoCyc)
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
NOT |
GO:0016301 |
kinase activity |
F |
Activity later shown to be associated with thiI, not yajL.[5] |
Missing: evidence | |||
| GO:0042026 |
protein refolding |
IMP: Inferred from Mutant Phenotype |
P |
From EcoCyc |
complete | |||
|
NOT |
GO:0008972 |
phosphomethylpyrimidine kinase activity |
F |
Activity later shown to be associated with thiI, not yajL.[5] |
Missing: evidence | |||
|
Deprecated |
GO:0005737 |
cytoplasm |
C |
The protein purified in the cited paper was later shown not to be YajL.[5] |
Missing: evidence | |||
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MNMSASALVC LAPGSEETEA VTTIDLLVRG GIKVTTASVA SDGNLAITCS RGVKLLADAP LVEVADGEYD VIVLPGGIKG AECFRDSTLL VETVKQFHRS GRIVAAICAA PATVLVPHDI FPIGNMTGFP TLKDKIPAEQ WLDKRVVWDA RVKLLTSQGP GTAIDFGLKI IDLLVGREKA HEVASQLVMA AGIYNYYE |
| Length |
198 |
| Mol. Wt |
21.022 kDa |
| pI |
5.1 (calculated) |
| Extinction coefficient |
16,960 - 17,460 (calc based on 4 Y, 2 W, and 4 C residues) |
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Domains/Motifs/Modification Sites
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<motif_map/> |
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Structure
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Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 5.3 Mueller, EG et al. (1998) Identification of a gene involved in the generation of 4-thiouridine in tRNA. Nucleic Acids Res. 26 2606-10 PubMed
- ↑ 6.0 6.1 6.2 Mizote, T & Nakayama, H (1989) Purification and properties of hydroxymethylpyrimidine kinase from Escherichia coli. Biochim. Biophys. Acta 991 109-13 PubMed
- ↑ Kthiri, F et al. (2010) Protein aggregation in a mutant deficient in yajL, the bacterial homolog of the Parkinsonism-associated protein DJ-1. J. Biol. Chem. 285 10328-36 PubMed
- ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
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