xdhD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

XdhD

Synonyms

fused predicted xanthine/hypoxanthine oxidase: molybdopterin-binding subunit[1], Fe-S binding subunit[1], B2881[2][1], YgfN[2][1], XdhD[2][1] , ECK2877, JW2849, ygfN, b2881

Product description

putative oxidoreductase; possible component of selenate reductase with possible role in purine salvage[2][3];

Component of putative selenate reductase[3]

Probable hypoxanthine dehydrogenase; mutation confers adenine sensitivity[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005506

iron ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0408

F

Seeded from EcoCyc (v14.0)

complete

GO:0006144

purine base metabolic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0659

P

Seeded from EcoCyc (v14.0)

complete

GO:0006166

purine ribonucleoside salvage

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0660

P

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000674

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002888

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008274

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc (v14.0)

complete

GO:0030151

molybdenum ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0500

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002888

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

GO:0051536

iron-sulfur cluster binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0411

F

Seeded from EcoCyc (v14.0)

complete

GO:0051537

2 iron, 2 sulfur cluster binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0001

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000674

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002888

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008274

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0005575

cellular component

127.0.0.1 14:56, 17 February 2015 (CST)

ND: No biological Data available

C

Missing: reference

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of putative selenate reductase

could be indirect

Protein

yghW

PMID:16606699[5]

Experiment(s):EBI-1144187

Protein

valS

PMID:16606699[5]

Experiment(s):EBI-1144187

Protein

ygfM

PMID:19402753[6]

MALDI(Z-score):21.289090

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MIIHFTLNGA PQELTVNPGE NVQKLLFNMG MHSVRNSDDG FGFAGSDAII FNGNIVNASL
LIAAQLEKAD IRTAESLGKW NELSLVQQAM VDVGVVQSGY NDPAAALIIT DLLDRIAAPT
REEIDDALSG LFSRDAGWQQ YYQVIELAVA RKNNPQATID IAPTFRDDLE VIGKHYPKTD
AAKMVQAKPC YVEDRVTADA CVIKMLRSPH AHALITHLDV SKAEALPGVV HVITHLNCPD
IYYTPGGQSA PEPSPLDRRM FGKKMRHVGD RVAAVVAESE EIALEALKLI DVEYEVLKPV
MSIDEAMAED APVVHDEPVV YVAGAPDTLE DDNSHAAQRG EHMIINFPIG SRPRKNIAAS
IHGHIGDMDK GFADADVIIE RTYNSTQAQQ CPTETHICFT RMDGDRLVIH ASTQVPWHLR
RQVARLVGMK QHKVHVIKER VGGGFGSKQD ILLEEVCAWA TCVTGRPVLF RYTREEEFIA
NTSRHVAKVT VKLGAKKDGR LTAVKMDFRA NTGPYGNHSL TVPCNGPALS LPLYPCDNVD
FQVTTYYSNI CPNGAYQGYG APKGNFAITM ALAELAEQLQ IDQLEIIERN RVHEGQELKI
LGAIGEGKAP TSVPSAASCA LEEILRQGRE MIQWSSPKPQ NGDWHIGRGV AIIMQKSGIP
DIDQANCMIK LESDGTFIVH SGGADIGTGL DTVVTKLAAE VLHCPPQDVH VISGDTDHAL
FDKGAYASSG TCFSGNAARL AAENLREKIL FHGAQMLGEP VADVQLATPG VVRGKKGEVS
FGDIAHKGET GTGFGSLVGT GSYITPDFAF PYGANFAEVA VNTRTGEIRL DKFYALLDCG
TPVNPELALG QIYGATLRAI GHSMSEEIIY DAEGHPLTRD LRSYGAPKIG DIPRDFRAVL
VPSDDKVGPF GAKSISEIGV NGAAPAIATA IHDACGIWLR EWHFTPEKIL TALEKI
Length

956

Mol. Wt

103.518 kDa

pI

5.7 (calculated)

Extinction coefficient

79,760 - 81,760 (calc based on 24 Y, 8 W, and 16 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

186..298

PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

PMID:19920124[7]

Domain

351..893

PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase

PMID:19920124[7]

Domain

73..147

PF01799 [2Fe-2S binding domain]

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=xdhD taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130783

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949079

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009459

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:Q46814

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7500

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13064

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949079

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004063

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2876

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ 7.0 7.1 7.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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