uvrY:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

UvrY

Synonyms

DNA-binding response regulator in two-component regulatory system with BarA [1], YecB [2][1], B1914 [2][1], UvrY-Pasp [2][1] , ECK1913, gacA, JW1899, sirA, yecB, b1914

Product description

UvrY transcriptional regulator[2][3]

Response regulator, pleiotrpic; controls the expression of csrB/C sRNAs; hydrogen peroxide resistance; cognate sensorregulator is BarA[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000156

two-component response regulator activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

F

Seeded from EcoCyc (v14.0)

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

P

Seeded from EcoCyc (v14.0)

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0902

P

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000792

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000792

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000792

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

P

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000792

F

Seeded from EcoCyc (v14.0)

complete

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Interactions


See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

lpdA

PMID:15690043[5]

Experiment(s):EBI-880857

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-880857

Protein

hscC

PMID:15690043[5]

Experiment(s):EBI-887064

Protein

fimZ

PMID:15690043[5]

Experiment(s):EBI-887064

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-887064

Protein

yghW

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

rpsM

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

narX

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

ahpF

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

yciH

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

murB

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

nagZ

PMID:16606699[6]

Experiment(s):EBI-1141304

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):18.715338

Protein

hscC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

fimZ

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MINVLLVDDH ELVRAGIRRI LEDIKGIKVV GEASCGEDAV KWCRTNAVDV VLMDMSMPGI
GGLEATRKIA RSTADVKIIM LTVHTENPLP AKVMQAGAAG YLSKGAAPQE VVSAIRSVYS
GQRYIASDIA QQMALSQIEP EKTESPFASL SERELQIMLM ITKGQKVNEI SEQLNLSPKT
VNSYRYRMFS KLNIHGDVEL THLAIRHGLC NAETLSSQ
Length

218

Mol. Wt

23.892 kDa

pI

7.0 (calculated)

Extinction coefficient

12,950 - 13,325 (calc based on 5 Y, 1 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

147..204

PF00196 Bacterial regulatory proteins, luxR family

PMID:19920124[8]

Domain

4..116

PF00072 Response regulator receiver domain

PMID:19920124[8]

Modification Site

Phosphorylation

phosphorylated by BarA

PMID:11022030[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=uvrY taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129861

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946424

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006373

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AED5

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11140

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11140

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946424

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001124

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1130

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
  9. ↑ Pernestig, AK et al. (2001) Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli. J. Biol. Chem. 276 225-31 PubMed

Categories

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