uhpC:Gene Product(s)

From EcoliWiki
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

UhpC

Synonyms

B3667[1], regulatory protein UhpC[1], unmodified regulatory protein UhpC[1] , ECK3658, JW3642, b3667

Product description

UhpC[1][2]

Glc6P transporter; membrane sensor recognizing external glucose-6-phosphate (Glc6P) and, in concert with UhpB, inducing uhpT[3]

EC number (for enzymes)


edit table

<protect></protect>

Notes

Function

[back to top]


<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005886

plasma membrane

PMID:1569007[4]

IDA: Inferred from Direct Assay

C

Location and topology determined based on activity of PhoA fusions to UhpC.

complete

GO:0005215

transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000849

F

Seeded from EcoCyc (v14.0)

complete

GO:0005624

membrane fraction

PMID:12654000[5]

IDA: Inferred from Direct Assay

C

Anti-His6 antibody detection of UhpC-His in total membrane fraction.

See discussion page for mistake in references listed in this paper.

complete

GO:0031226

intrinsic to plasma membrane

PMID:1569007[4]

IDA: Inferred from Direct Assay

C

Location and topology in plasma membrane determined using UhpC-PhoA gene fusions.

complete

GO:0005624

membrane fraction

PMID:12654000[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

PMID:1569007[4]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000849

P

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0008643

carbohydrate transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0762

P

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000849

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0031226

intrinsic to plasma membrane

PMID:1569007[4]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0055085

transmembrane transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011701

P

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
edit table

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 12 predicted transmembrane domains

Daley et al. (2005) [6]

plasma membrane

From EcoCyc[2]


edit table

<protect></protect>

Notes

Structure and Physical Properties

[back to top]


<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MMLPFLKAPA DAPLMTDKYE IDARYRYWRR HILLTIWLGY ALFYFTRKSF NAAVPEILAN
GVLSRSDIGL LATLFYITYG VSKFVSGIVS DRSNARYFMG IGLIATGIIN ILFGFSTSLW
AFAVLWVLNA FFQGWGSPVC ARLLTAWYSR TERGGWWALW NTAHNVGGAL IPIVMAAAAL
HYGWRAGMMI AGCMAIVVGI FLCWRLRDRP QALGLPAVGE WRHDALEIAQ QQEGAGLTRK
EILTKYVLLN PYIWLLSFCY VLVYVVRAAI NDWGNLYMSE TLGVDLVTAN TAVTMFELGG
FIGALVAGWG SDKLFNGNRG PMNLIFAAGI LLSVGSLWLM PFASYVMQAT CFFTIGFFVF
GPQMLIGMAA AECSHKEAAG AATGFVGLFA YLGASLAGWP LAKVLDTWHW SGFFVVISIA
AGISALLLLP FLNAQTPREA
Length

440

Mol. Wt

48.389 kDa

pI

8.9 (calculated)

Extinction coefficient

129,830 - 130,580 (calc based on 17 Y, 19 W, and 6 C residues)

edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

35..397

PF07690 Major Facilitator Superfamily

PMID:19920124[7]

edit table

<motif_map/>

tmhmm.php?gene=uhpC&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=uhpC taxon=562,83333 </beststructure>

Models

View models at:

edit table
</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table

<protect></protect>

Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111632

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948184

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011990

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P09836

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11053

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11053

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948184

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001042

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1046

Escherichia coli str. K-12 substr. MG1655

edit table

<protect></protect>

Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 4.2 4.3 Island, MD et al. (1992) Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium. J. Bacteriol. 174 2754-62 PubMed
  5. ↑ 5.0 5.1 Schwöppe, C et al. (2003) Connection of transport and sensing by UhpC, the sensor for external glucose-6-phosphate in Escherichia coli. Eur. J. Biochem. 270 1450-7 PubMed
  6. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

[back to top]


Retrieved from "https://ecoliwiki.org/colipedia/index.php?title=uhpC:Gene_Product(s)&oldid=1495447"