tusA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TusA

Synonyms

conserved protein required for cell growth[1], B3470[2][1], YhhP[2][1], SirA[2][1], TusA[2][1] , TusA, ECK3454, JW3435, tusA, yhhP, b3470

Product description

sulfur transfer protein[2][3]

2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis; motility defect; affects RpoS stability; may bind RNA; mutants form filaments dues to disruption of ftsZ ring; suppressed by multicopy ftsZ or dksA; required for cell growth[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001455

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00413

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001455

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0008033

tRNA processing

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001455

P

Seeded from EcoCyc (v14.0)

complete

GO:0008033

tRNA processing

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0819

P

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0016783

sulfurtransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00413

F

Seeded from EcoCyc (v14.0)

complete

GO:0016783

sulfurtransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001455

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

lacZ

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

nadE

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

glnA

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

aceA

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

mngB

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

rho

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

iscS

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

prs

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

ybaA

PMID:16606699[5]

Experiment(s):EBI-1145987

Protein

aceE

PMID:15690043[6]

Experiment(s):EBI-888431

Protein

iscS

PMID:15690043[6]

Experiment(s):EBI-888431, EBI-893577

Protein

gapA

PMID:15690043[6]

Experiment(s):EBI-893805

Protein

skp

PMID:15690043[6]

Experiment(s):EBI-893805

Protein

rplL

PMID:15690043[6]

Experiment(s):EBI-893805

Protein

rpoB

PMID:15690043[6]

Experiment(s):EBI-893805

Protein

yjeE

PMID:15690043[6]

Experiment(s):EBI-893805

Protein

skp

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ravA

PMID:19402753[7]

MALDI(Z-score):27.217898

Protein

iscS

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):39.615124

Protein

rpoB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

yjeE

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

gapA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ddpA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MTDLFSSPDH TLDALGLRCP EPVMMVRKTV RNMQPGETLL IIADDPATTR DIPGFCTFME
HELVAKETDG LPYRYLIRKG G
Length

81

Mol. Wt

9.094 kDa

pI

5.1 (calculated)

Extinction coefficient

2,980 - 3,230 (calc based on 2 Y, 0 W, and 2 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

10..79

PF01206 SirA-like protein

PMID:19920124[8]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=sirA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

<protect>

</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131342

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947974

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011336

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A890

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12216

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12216

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947974

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002103

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2130

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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