trxA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TrxA

Synonyms

thioredoxin 1[1], B3781[2][1], DasC[2][1], TsnC[2][1], FipA[2][1], thioredoxin(S)2[2][1] , dasC, ECK3773, fipA, JW5856, tsnC, b3781

Product description

oxidized thioredoxin[2][3]

Thioredoxin 1; Trx; with TrxB, also has general chaperone activity; processivity factor for phage T7 gene 5 DNA polymerase[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology

oxidized thioredoxin

See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006662

glycerol ether metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005746

P

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0009055

electron carrier activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005746

F

Seeded from EcoCyc (v14.0)

complete

GO:0015035

protein disulfide oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005746

F

Seeded from EcoCyc (v14.0)

complete

GO:0022900

electron transport chain

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0249

P

Seeded from EcoCyc (v14.0)

complete

GO:0044419

interspecies interaction between organisms

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0945

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005746

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006662

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013766

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015467

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017936

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017937

P

Seeded from EcoCyc (v14.0)

complete

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Interactions

oxidized thioredoxin

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

fdoG

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

pykA

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

acnB

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in detergent, freeze-thaw treatment in Tris-EDTA & total cell lysates

Protein

icd

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA & total cell lysates

Protein

katG

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in detergent

Protein

sodA

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

putA

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

lamB

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in detergent

Protein

rbsB

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

sdaB

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA

Protein

lacZ

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA & total cell lysates

Protein

nrdD

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

nrdA

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

fadB

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

add

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA

Protein

tdk

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

udp

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

sthA

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA & total cell lysates

Protein

ompF

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in detergent

Protein

ompC

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA

Protein

prc

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

glmM

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

flu

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in detergent

Protein

yjiA

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA

Protein

yqaB

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA

Protein

mqo

PMID:15004283[5]

Interaction isolated from freeze-thaw treatment in Tris-EDTA & total cell lysates

Protein

yebE

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

obgE

PMID:15004283[5]

Interaction isolated from total cell lysates

Protein

dnaN

PMID:19402753[6]

MALDI(Z-score):25.219947

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MRITIILVAP ARAENIGAAA RAMKTMGFSD LRIVDSQAHL EPATRWVAHG SGDIIDNIKV
FPTLAESLHD VDFTVATTAR SRAKYHYYAT PVELVPLLEE KSSWMSHAAL VFGREDSGLT
NEELALADVL TGVPMVADYP SLNLGQAVMV YCYQLATLIQ QPAKSDATAD QHQLQALRER
AMTLLTTLAV ADDIKLVDWL QQRLGLLEQR DTAMLHRLLH DIEKNITK
Length

228

Mol. Wt

25.259 kDa

pI

5.9 (calculated)

Extinction coefficient

25,440 - 25,565 (calc based on 6 Y, 3 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0AA25

Domain

4..107

PF00085 Thioredoxin

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=trxA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:67005950

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948289

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012357

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AA25

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11031

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11031

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948289

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001020

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1024

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 Kumar, JK et al. (2004) Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 101 3759-64 PubMed
  6. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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