tpiA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TpiA

Synonyms

triosephosphate isomerase[1], B3919[2][1], Tpi[2][1], TpiA[2][1] , ECK3911, JW3890, tpi, b3919

Product description

triose phosphate isomerase[2][3];

Component of triose phosphate isomerase[2][3]

Triosephosphate isomerase[4]

EC number (for enzymes) 
5.3.1.1[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004807

triose-phosphate isomerase activity

PMID:6214548[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0004807

triose-phosphate isomerase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00147

F

Seeded from EcoCyc (v14.0)

complete

GO:0006094

gluconeogenesis

PMID:11947134[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0004807

triose-phosphate isomerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000652

F

Seeded from EcoCyc (v14.0)

complete

GO:0004807

triose-phosphate isomerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:5.3.1.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006094

gluconeogenesis

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00147

P

Seeded from EcoCyc (v14.0)

complete

GO:0006094

gluconeogenesis

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0312

P

Seeded from EcoCyc (v14.0)

complete

GO:0006096

glycolysis

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00147

P

Seeded from EcoCyc (v14.0)

complete

GO:0006096

glycolysis

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0324

P

Seeded from EcoCyc (v14.0)

complete

GO:0006098

pentose-phosphate shunt

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00147

P

Seeded from EcoCyc (v14.0)

complete

GO:0006098

pentose-phosphate shunt

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0570

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0004807

triose-phosphate isomerase activity

PMID:6092857[8]

ISA: Inferred from Sequence Alignment

UniProtKB:P00943

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of triose phosphate isomerase

Protein

manX

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

fdhE

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

fur

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

ydfK

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

prs

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

argG

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

rplQ

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

waaU

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

ynaE

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

ybfL

PMID:16606699[9]

Experiment(s):EBI-1147023

Protein

dnaK

PMID:15690043[10]

Experiment(s):EBI-879853

Protein

entB

PMID:15690043[10]

Experiment(s):EBI-884726

Protein

lysU

PMID:15690043[10]

Experiment(s):EBI-884726

Protein

rpmB

PMID:15690043[10]

Experiment(s):EBI-884726

Protein

rpoA

PMID:15690043[10]

Experiment(s):EBI-884726

Protein

rpsB

PMID:15690043[10]

Experiment(s):EBI-884726

Protein

rlmN

PMID:15690043[10]

Experiment(s):EBI-884726

Protein

rlmN

PMID:19402753[11]

LCMS(ID Probability):99.0

Protein

rpoA

PMID:19402753[11]

LCMS(ID Probability):99.5

Protein

lysU

PMID:19402753[11]

LCMS(ID Probability):99.6

Protein

yfiD

PMID:19402753[11]

LCMS(ID Probability):99.0 MALDI(Z-score):37.692748

Protein

pepT

PMID:19402753[11]

LCMS(ID Probability):99.0 MALDI(Z-score):36.843229

Protein

pflB

PMID:19402753[11]

LCMS(ID Probability):99.0 MALDI(Z-score):38.165574

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Cytosol


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MRHPLVMGNW KLNGSRHMVH ELVSNLRKEL AGVAGCAVAI APPEMYIDMA KREAEGSHIM
LGAQNVDLNL SGAFTGETSA AMLKDIGAQY IIIGHSERRT YHKESDELIA KKFAVLKEQG
LTPVLCIGET EAENEAGKTE EVCARQIDAV LKTQGAAAFE GAVIAYEPVW AIGTGKSATP
AQAQAVHKFI RDHIAKVDAN IAEQVIIQYG GSVNASNAAE LFAQPDIDGA LVGGASLKAD
AFAVIVKAAE AAKQA
Length

255

Mol. Wt

26.971 kDa

pI

5.8 (calculated)

Extinction coefficient

18,450 - 18,825 (calc based on 5 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

4..246

PF00121 Triosephosphate isomerase

PMID:19920124[12]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tpiA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131757

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948409

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012799

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A858

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11015

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11015

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948409

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001004

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1008

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Shimosaka, M et al. (1982) Application of hybrid plasmids carrying glycolysis genes to ATP production by Escherichia coli. J. Bacteriol. 152 98-103 PubMed
  6. ↑ Anderson, A & Cooper, RA (1969) Gluconeogenesis in Escherichia coli The role of triose phosphate isomerase. FEBS Lett. 4 19-20 PubMed
  7. ↑ 7.0 7.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  8. ↑ Pichersky, E et al. (1984) Nucleotide sequence of the triose phosphate isomerase gene of Escherichia coli. Mol. Gen. Genet. 195 314-20 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  11. ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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