tnaA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TnaA

Synonyms

tryptophanase/L-cysteine desulfhydrase, PLP-dependent[1], B3708[2][1], Ind[2][1], TnaR[2][1], TnaA[2][1] , ECK3701, ind, JW3686, b3708

Product description

TnaA[2][3];

Component of TRYPTOPHAN-CPLX[2]

Tryptophanase, also has cysteine desulfhydrase activity; interconverts tryptophan and indole; also called L-tryptophan indole-lyase;[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006520

cellular amino acid metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001597

P

Seeded from EcoCyc (v14.0)

complete

GO:0006568

tryptophan metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013440

P

Seeded from EcoCyc (v14.0)

complete

GO:0006569

tryptophan catabolic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00544

P

Seeded from EcoCyc (v14.0)

complete

GO:0006569

tryptophan catabolic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0823

P

Seeded from EcoCyc (v14.0)

complete

GO:0009034

tryptophanase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00544

F

Seeded from EcoCyc (v14.0)

complete

GO:0009034

tryptophanase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013440

F

Seeded from EcoCyc (v14.0)

complete

GO:0009034

tryptophanase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.99.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0009072

aromatic amino acid family metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011166

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001597

F

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0016830

carbon-carbon lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011166

F

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of TRYPTOPHAN-CPLX

could be indirect

Protein

dnaK

PMID:15690043[6]

Experiment(s):EBI-878854
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKDYVMENFK HLPEPFRIRV IEPVKRTTRA YREEAIIKSG MNPFLLDSED VFIDLLTDSG
TGAVTQSMQA AMMRGDEAYS GSRSYYALAE SVKNIFGYQY TIPTHQGRGA EQIYIPVLIK
KREQEKGLDR SKMVAFSNYF FDTTQGHSQI NGCTVRNVYI KEAFDTGVRY DFKGNFDLEG
LERGIEEVGP NNVPYIVATI TSNSAGGQPV SLANLKAMYS IAKKYDIPVV MDSARFAENA
YFIKQREAEY KDWTIEQITR ETYKYADMLA MSAKKDAMVP MGGLLCMKDD SFFDVYTECR
TLCVVQEGFP TYGGLEGGAM ERLAVGLYDG MNLDWLAYRI AQVQYLVDGL EEIGVVCQQA
GGHAAFVDAG KLLPHIPADQ FPAQALACEL YKVAGIRAVE IGSFLLGRDP KTGKQLPCPA
ELLRLTIPRA TYTQTHMDFI IEAFKHVKEN AANIKGLTFT YEPKVLRHFT AKLKEV
Length

476

Mol. Wt

53.411 kDa

pI

6.2 (calculated)

Extinction coefficient

49,740 - 50,615 (calc based on 26 Y, 2 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Modification Site

93

phosphorylation site at Y93

probability greater than 75%

PMID:17938405[7]

Domain

49..438

PF01212 Beta-eliminating lyase

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tnaA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111643

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948221

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012133

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A853

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11005

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11005

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948221

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000994

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0998

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ Macek, B et al. (2008) Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol. Cell Proteomics 7 299-307 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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