tdcE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TdcE

Synonyms

pyruvate formate-lyase 4/2-ketobutyrate formate-lyase[1], B3114[2][1], YhaS[2][1], 2-ketobutyrate formate-lyase, active[2][1], pyruvate formate-lyase 4[2][1], PFL4[2][1] , ECK3103, JW5522, yhaS, b3114

Product description

Pyruvate formate-lyase/ketobutyrate formate-lyase[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology

KETOBUTFORMLY-MONOMER

See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001150

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004184

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005949

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0005975

carbohydrate metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005949

P

Seeded from EcoCyc (v14.0)

complete

GO:0006006

glucose metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004184

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001150

P

Seeded from EcoCyc (v14.0)

complete

GO:0008415

acyltransferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc (v14.0)

complete

GO:0008861

formate C-acetyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004184

F

Seeded from EcoCyc (v14.0)

complete

GO:0008861

formate C-acetyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005949

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0043875

2-ketobutyrate formate-lyase activity

PMID:9484901[4]

IGI: Inferred from Genetic Interaction

EcoliWiki:pflB


F

complete

GO:0005737

cytoplasm

PMID:9484901[4]

IDA: Inferred from Direct Assay

C

complete

GO:0070689

threonine catabolic process to propionate

PMID:9484901[4]

IC: Inferred by Curator

GO:0043875


P

complete

GO:0005624

membrane fraction

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

complete

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Interactions

KETOBUTFORMLY-MONOMER

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[6]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKVDIDTSDK LYADAWLGFK GTDWKNEINV RDFIQHNYTP YEGDESFLAE ATPATTELWE
KVMEGIRIEN ATHAPVDFDT NIATTITAHD AGYINQPLEK IVGLQTDAPL KRALHPFGGI
NMIKSSFHAY GREMDSEFEY LFTDLRKTHN QGVFDVYSPD MLRCRKSGVL TGLPDGYGRG
RIIGDYRRVA LYGISYLVRE RELQFADLQS RLEKGEDLEA TIRLREELAE HRHALLQIQE
MAAKYGFDIS RPAQNAQEAV QWLYFAYLAA VKSQNGGAMS LGRTASFLDI YIERDFKAGV
LNEQQAQELI DHFIMKIRMV RFLRTPEFDS LFSGDPIWAT EVIGGMGLDG RTLVTKNSFR
YLHTLHTMGP APEPNLTILW SEELPIAFKK YAAQVSIVTS SLQYENDDLM RTDFNSDDYA
IACCVSPMVI GKQMQFFGAR ANLAKTLLYA INGGVDEKLK IQVGPKTAPL MDDVLDYDKV
MDSLDHFMDW LAVQYISALN IIHYMHDKYS YEASLMALHD RDVYRTMACG IAGLSVATDS
LSAIKYARVK PIRDENGLAV DFEIDGEYPQ YGNNDERVDS IACDLVERFM KKIKALPTYR
NAVPTQSILT ITSNVVYGQK TGNTPDGRRA GTPFAPGANP MHGRDRKGAV ASLTSVAKLP
FTYAKDGISY TFSIVPAALG KEDPVRKTNL VGLLDGYFHH EADVEGGQHL NVNVMNREML
LDAIEHPEKY PNLTIRVSGY AVRFNALTRE QQQDVISRTF TQAL
Length

764

Mol. Wt

85.937 kDa

pI

5.6 (calculated)

Extinction coefficient

92,140 - 92,765 (calc based on 36 Y, 7 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

634..745

PF01228 Glycine radical

PMID:19920124[7]

Domain

22..618

PF02901 Pyruvate formate lyase

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tdcE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:49176316

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947623

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010242

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P42632

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7627

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12758

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947623

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004178

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2612

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 4.2 Hesslinger, C et al. (1998) Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate. Mol. Microbiol. 27 477-92 PubMed
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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