tas:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Tas

Synonyms

predicted oxidoreductase, NADP(H)-dependent aldo-keto reductase[1], B2834[2][1], YgdS[2][1], Tas[2][1] , ECK2830, JW2802, ygdS, b2834

Product description

putative NAD(P)-linked reductase that acts in starvation-associated mutation[2][3]

Suppresses tyrosine requirement of tyrA14 O6 strain; probable aldo-keto reductase, NADP(H)-dependent[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001395

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020471

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001395

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020471

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0034198

cellular response to amino acid starvation

PMID:9560382[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0004033

aldo-keto reductase activity

PMID:14517983[6]

TAS: Traceable Author Statement

F

complete

GO:0005575

cellular component

127.0.0.1 14:56, 17 February 2015 (CST)

ND: No biological Data available

C

Missing: reference

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1144115

Protein

otsB

PMID:16606699[7]

Experiment(s):EBI-1144115

Protein

mnmG

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

pbpG

PMID:19402753[8]

LCMS(ID Probability):99.6

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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MQYHRIPHSS LEVSTLGLGT MTFGEQNSEA DAHAQLDYAV AQGINLIDVA EMYPVPPRPE
TQGLTETYVG NWLAKHGSRE KLIIASKVSG PSRNNDKGIR PDQALDRKNI REALHDSLKR
LQTDYLDLYQ VHWPQRPTNC FGKLGYSWTD SAPAVSLLDT LDALAEYQRA GKIRYIGVSN
ETAFGVMRYL HLADKHDLPR IVTIQNPYSL LNRSFEVGLA EVSQYEGVEL LAYSCLGFGT
LTGKYLNGAK PAGARNTLFS RFTRYSGEQT QKAVAAYVDI ARRHGLDPAQ MALAFVRRQP
FVASTLLGAT TMDQLKTNIE SLHLELSEDV LAEIEAVHQV YTYPAP
Length

346

Mol. Wt

38.499 kDa

pI

6.7 (calculated)

Extinction coefficient

43,320 - 43,570 (calc based on 18 Y, 3 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

15..339

PF00248 Aldo/keto reductase family

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tas taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130738

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947306

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009298

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A9T4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7462

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13093

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947306

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004025

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2898

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Timms, AR & Bridges, BA (1998) Reversion of the tyrosine ochre strain Escherichia coli WU3610 under starvation conditions depends on a new gene tas. Genetics 148 1627-35 PubMed
  6. ↑ Obmolova, G et al. (2003) Crystal structure of the Escherichia coli Tas protein, an NADP(H)-dependent aldo-keto reductase. Proteins 53 323-5 PubMed
  7. ↑ 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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