surA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SurA

Synonyms

peptidyl-prolyl cis-trans isomerase (PPIase)[1], B0053[2][1], SurA[2][1] , ECK0054, JW0052, b0053

Product description

peptidyl-prolyl cis-trans isomerase (PPIase)[2][3]

Periplasmic OM porin chaperone, has PPIase activity; required for stationary-phase survival[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030288

outer membrane-bounded periplasmic space

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01183

F

Seeded from EcoCyc (v14.0)

complete

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:5.2.1.8

F

Seeded from EcoCyc (v14.0)

complete

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0697

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01183

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

PMID:11226178[5]

IPI: Inferred from Physical Interaction

UniProtKB:P02931

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

PMID:11226178[5]

IPI: Inferred from Physical Interaction

UniProtKB:P02932

F

Seeded from EcoCyc (v14.0)

complete

GO:0060274

maintenance of stationary phase

PMID:2165476[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0051082

unfolded protein binding

PMID:11226178[5]

IPI: Inferred from Physical Interaction

UniProtKB:P02943

F

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

PMID:8626309[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0050821

protein stabilization

PMID:8626309[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

PMID:8985185[8]

IDA: Inferred from Direct Assay

F

complete

GO:0043165

Gram-negative-bacterium-type cell outer membrane assembly

PMID:8985185[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030288

outer membrane-bounded periplasmic space

PMID:8985185[8]

IDA: Inferred from Direct Assay

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

dnaK

PMID:16606699[9]

Experiment(s):EBI-1135459

Protein

hflB

PMID:16606699[9]

Experiment(s):EBI-1135459

Protein

chbC

PMID:15690043[10]

Experiment(s):EBI-891312

Protein

ilvA

PMID:15690043[10]

Experiment(s):EBI-891312

Protein

lpdA

PMID:15690043[10]

Experiment(s):EBI-891312

Protein

rplL

PMID:15690043[10]

Experiment(s):EBI-891312

Protein

rpsN

PMID:15690043[10]

Experiment(s):EBI-891312

Protein

ydaY

PMID:15690043[10]

Experiment(s):EBI-891312

Protein

ilvA

PMID:19402753[11]

LCMS(ID Probability):99.0

Protein

chbC

PMID:19402753[11]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

periplasm

Periplasm

PMID:9298646[12]

EchoLocation:surA


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKNWKTLLLG IAMIANTSFA APQVVDKVAA VVNNGVVLES DVDGLMQSVK LNAAQARQQL
PDDATLRHQI MERLIMDQII LQMGQKMGVK ISDEQLDQAI ANIAKQNNMT LDQMRSRLAY
DGLNYNTYRN QIRKEMIISE VRNNEVRRRI TILPQEVESL AQQVGNQNDA STELNLSHIL
IPLPENPTSD QVNEAESQAR AIVDQARNGA DFGKLAIAHS ADQQALNGGQ MGWGRIQELP
GIFAQALSTA KKGDIVGPIR SGVGFHILKV NDLRGESKNI SVTEVHARHI LLKPSPIMTD
EQARVKLEQI AADIKSGKTT FAAAAKEFSQ DPGSANQGGD LGWATPDIFD PAFRDALTRL
NKGQMSAPVH SSFGWHLIEL LDTRNVDKTD AAQKDRAYRM LMNRKFSEEA ASWMQEQRAS
AYVKILSN
Length

428

Mol. Wt

47.284 kDa

pI

7.0 (calculated)

Extinction coefficient

34,950 (calc based on 5 Y, 5 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-20

UniProt Manual:Signal Peptides

UniProt:P0ABZ6

Domain

178..272

PF00639 PPIC-type PPIASE domain

PMID:19920124[13]

Domain

289..382

PF00639 PPIC-type PPIASE domain

PMID:19920124[13]

Domain

25..142

PF09312 SurA N-terminal domain

PMID:19920124[13]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=surA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128047

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944812

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000180

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABZ6

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10985

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10985

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944812

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000974

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0978

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Behrens, S et al. (2001) The SurA periplasmic PPIase lacking its parvulin domains functions in vivo and has chaperone activity. EMBO J. 20 285-94 PubMed
  6. ↑ Tormo, A et al. (1990) surA, an Escherichia coli gene essential for survival in stationary phase. J. Bacteriol. 172 4339-47 PubMed
  7. ↑ 7.0 7.1 Lazar, SW & Kolter, R (1996) SurA assists the folding of Escherichia coli outer membrane proteins. J. Bacteriol. 178 1770-3 PubMed
  8. ↑ 8.0 8.1 8.2 Rouvière, PE & Gross, CA (1996) SurA, a periplasmic protein with peptidyl-prolyl isomerase activity, participates in the assembly of outer membrane porins. Genes Dev. 10 3170-82 PubMed
  9. ↑ 9.0 9.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  11. ↑ 11.0 11.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ Link, AJ et al. (1997) Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis 18 1259-313 PubMed
  13. ↑ 13.0 13.1 13.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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