sufA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SufA

Synonyms

Fe-S cluster assembly protein[1], YdiC[2][1], SufA[2][1], B1684[2][1] , ECK1680, JW1674, ydiC, b1684

Product description

Fe-S cluster assembly protein[2][3]

Scaffold protein for assembly of iron-sulfur clusters; facilitates delivery to target proteins[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005198

structural molecule activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016092

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:19810706[5]

IPI: Inferred from Physical Interaction

UniProtKB:P77522
UniProtKB:P77499

F

Seeded from EcoCyc (v14.0)

complete

GO:0006979

response to oxidative stress

PMID:15009899[6]

IEP: Inferred from Expression Pattern

P

Seeded from EcoCyc (v14.0)

complete

GO:0006979

response to oxidative stress

PMID:15009899[6]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0016226

iron-sulfur cluster assembly

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016092

P

Seeded from EcoCyc (v14.0)

complete

GO:0016226

iron-sulfur cluster assembly

PMID:19478995[7]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0042803

protein homodimerization activity

PMID:19366265[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0051537

2 iron, 2 sulfur cluster binding

PMID:19366265[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ybgE

PMID:16606699[9]

Experiment(s):EBI-1140500

Protein

ydhZ

PMID:16606699[9]

Experiment(s):EBI-1140500

Protein

nadE

PMID:16606699[9]

Experiment(s):EBI-1140500

Protein

yfjU

PMID:16606699[9]

Experiment(s):EBI-1140500
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MDMHSGTFNP QDFAWQGLTL TPAAAIHIRE LVAKQPGMVG VRLGVKQTGC AGFGYVLDSV
SEPDKDDLLF EHDGAKLFVP LQAMPFIDGT EVDFVREGLN QIFKFHNPKA QNECGCGESF GV
Length

122

Mol. Wt

13.299 kDa

pI

4.7 (calculated)

Extinction coefficient

6,990 - 7,365 (calc based on 1 Y, 1 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

18..108

PF01521 Iron-sulphur cluster biosynthesis

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=sufA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129640

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949014

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0005624

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P77667

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11378

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11378

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949014

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001346

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1352

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Chahal, HK et al. (2009) The SufBCD Fe-S scaffold complex interacts with SufA for Fe-S cluster transfer. Biochemistry 48 10644-53 PubMed
  6. ↑ 6.0 6.1 Lee, JH et al. (2004) Induction of the sufA operon encoding Fe-S assembly proteins by superoxide generators and hydrogen peroxide: involvement of OxyR, IHF and an unidentified oxidant-responsive factor. Mol. Microbiol. 51 1745-55 PubMed
  7. ↑ Vinella, D et al. (2009) Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers. PLoS Genet. 5 e1000497 PubMed
  8. ↑ 8.0 8.1 Gupta, V et al. (2009) Native Escherichia coli SufA, coexpressed with SufBCDSE, purifies as a [2Fe-2S] protein and acts as an Fe-S transporter to Fe-S target enzymes. J. Am. Chem. Soc. 131 6149-53 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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