secE:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
SecE |
|---|---|
| Synonyms |
preprotein translocase membrane subunit[1], EG10939[2][1], B3981[2][1], MbrC[2][1], PrlG[2][1], SecE[2][1] , ECK3972, JW3944, mbrC, prlG, b3981 |
| Product description |
Component of SecEGY-Secretion Complex[2][3]; Sec Protein Secretion Complex[2][3] SecYE core translocon, protein export inner membrane pore protein[4] |
| EC number (for enzymes) |
|
| edit table |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
IGI: Inferred from Genetic Interaction |
F |
Seeded from EcoCyc (v14.0) |
Missing: with/from | |||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006605 |
protein targeting |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006810 |
transport |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006886 |
intracellular protein transport |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009306 |
protein secretion |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0015450 |
P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-9909 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0043952 |
protein transport by the Sec complex |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| GO:0065002 |
intracellular protein transmembrane transport |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| GO:0006886 |
intracellular protein transport |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| GO:0016021 |
integral to membrane |
IMP: Inferred from Mutant Phenotype |
C |
complete | ||||
| GO:0005886 |
plasma membrane |
IMP: Inferred from Mutant Phenotype |
C |
complete | ||||
| GO:0016021 |
integral to membrane |
IDA: Inferred from Direct Assay |
C |
complete | ||||
| GO:0005515 |
protein binding |
IGI: Inferred from Genetic Interaction |
EcoliWiki:secY |
F |
complete | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of SecEGY-Secretion Complex |
could be indirect |
||
|
Protein |
Subunits of Sec Protein Secretion Complex |
could be indirect |
| |
| edit table |
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
|
plasma membrane |
C-terminus localized to the periplasm with 3 predicted transmembrane domains |
Daley et al. (2005) [8] |
| |
| edit table |
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MSANTEAQGS GRGLEAMKWV VVVALLLVAI VGNYLYRDIM LPLRALAVVI LIAAAGGVAL LTTKGKATVA FAREARTEVR KVIWPTRQET LHTTLIVAAV TAVMSLILWG LDGILVRLVS FITGLRF |
| Length |
127 |
| Mol. Wt |
13.643 kDa |
| pI |
11.0 (calculated) |
| Extinction coefficient |
19,480 (calc based on 2 Y, 3 W, and 0 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
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Structure
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Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
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Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 Homma, T et al. (1997) Subunit interactions in the Escherichia coli protein translocase: SecE and SecG associate independently with SecY. FEBS Lett. 408 11-5 PubMed
- ↑ 6.0 6.1 6.2 Riggs, PD et al. (1988) A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics 118 571-9 PubMed
- ↑ 7.0 7.1 Schatz, PJ et al. (1989) The secE gene encodes an integral membrane protein required for protein export in Escherichia coli. Genes Dev. 3 1035-44 PubMed
- ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
- ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0005515 ! protein binding
- GO:0005886 ! plasma membrane
- GO:0006605 ! protein targeting
- GO:0006810 ! transport
- GO:0006886 ! intracellular protein transport
- GO:0009306 ! protein secretion
- GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity
- GO:0016021 ! integral component of membrane
- GO:0043952 ! protein transport by the Sec complex
- GO:0065002 ! intracellular protein transmembrane transport
- TMHMM Prediction
- Proteins
