purE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PurE

Synonyms

N5-carboxyaminoimidazole ribonucleotide mutase[1], B0523[2][1], PurE[2][1], purE1 peptide[2][1], catalytic subunit[2][1], N5-CAIR mutase[2][1], AIR carboxylase subunit[2][1], N5-carboxyaminoimidazole ribonucleotide mutase subunit[2][1] , ade, ade3, ECK0516, JW0512, Pur2, b0523

Product description

PurE[2][3];

Component of N5-carboxyaminoimidazole ribonucleotide mutase[2][3]

N5-carboxyaminoimidazole ribonucleotide (N-CAIR) mutase; purine synthesis[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004638

phosphoribosylaminoimidazole carboxylase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000031

F

Seeded from EcoCyc (v14.0)

complete

GO:0004638

phosphoribosylaminoimidazole carboxylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.1.21

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006164

purine nucleotide biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0658

P

Seeded from EcoCyc (v14.0)

complete

GO:0006189

'de novo' IMP biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000031

P

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0016831

carboxy-lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0210

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of N5-carboxyaminoimidazole ribonucleotide mutase

could be indirect

Protein

Q79BD2

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

tatE

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

ispG

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

otsB

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

gabT

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

zwf

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

napC

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

degP

PMID:16606699[6]

Experiment(s):EBI-1137040

Protein

yibL

PMID:16606699[6]

Experiment(s):EBI-1137040
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSSRNNPARV AIVMGSKSDW ATMQFAAEIF EILNVPHHVE VVSAHRTPDK LFSFAESAEE
NGYQVIIAGA GGAAHLPGMI AAKTLVPVLG VPVQSAALSG VDSLYSIVQM PRGIPVGTLA
IGKAGAANAA LLAAQILATH DKELHQRLND WRKAQTDEVL ENPDPRGAA
Length

169

Mol. Wt

17.779 kDa

pI

6.5 (calculated)

Extinction coefficient

13,980 (calc based on 2 Y, 2 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0AG18

Domain

8..159

PF00731 AIR carboxylase

PMID:19920124[7]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=purE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128507

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949031

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001796

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AG18

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10793

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10793

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949031

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000784

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0786

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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