nadC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

NadC

Synonyms

quinolinate phosphoribosyltransferase[1], B0109[2][1], Nic[2][1], NadC[2][1], nicotinate-nucleotide pyrophosphorylase (carboxylating)[2][1], QAPRTase[2][1], nicotinate-nucleotide:pyrophosphate phospho-α-D-ribosyltransferase (carboxylating)[2][1] , ECK0108, JW0105, b0109

Product description

quinolinate phosphoribosyltransferase (decarboxylating)[2][3];

Component of quinolinate phosphoribosyltransferase (decarboxylating)[2][3]

Quinolinate phosphoribosyl transferase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0004514

nicotinate-nucleotide diphosphorylase (carboxylating) activity

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P30012

F

S. typhimurium NadC shown to have this activity (IDA). [5]

Missing: reference

GO:0004514

nicotinate-nucleotide diphosphorylase (carboxylating) activity

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P30012

F

PMID:203571[6] nadC mutant of Salmonella typhimurium requires nicotinate for growth on minimal medium (IMP, Table 4).

Missing: reference

GO:0004514

nicotinate-nucleotide diphosphorylase (carboxylating) activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002638

F

Seeded from EcoCyc (v14.0)

complete

GO:0004514

nicotinate-nucleotide diphosphorylase (carboxylating) activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004393

F

Seeded from EcoCyc (v14.0)

complete

GO:0004514

nicotinate-nucleotide diphosphorylase (carboxylating) activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.4.2.19

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:8561507[7]

IDA: Inferred from Direct Assay

C

complete

GO:0004514

nicotinate-nucleotide diphosphorylase (carboxylating) activity

PMID:8561507[7]

IDA: Inferred from Direct Assay

F

complete

GO:0009435

NAD biosynthetic process

PMID:8561507[7]

IDA: Inferred from Direct Assay

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of quinolinate phosphoribosyltransferase (decarboxylating)

could be indirect

Protein

dnaK

PMID:16606699[8]

Experiment(s):EBI-1135586

Protein

rpsS

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rplF

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

dksA

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rplK

PMID:19402753[9]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MPPRRYNPDT RRDELLERIN LDIPGAVAQA LREDLGGTVD ANNDITAKLL PENSRSHATV
ITRENGVFCG KRWVEEVFIQ LAGDDVTIIW HVDDGDVINA NQSLFELEGP SRVLLTGERT
ALNFVQTLSG VASKVRHYVE LLEGTNTQLL DTRKTLPGLR SALKYAVLCG GGANHRLGLS
DAFLIKENHI IASGSVRQAV EKASWLHPDA PVEVEVENLE ELDEALKAGA DIIMLDNFET
EQMREAVKRT NGKALLEVSG NVTDKTLREF AETGVDFISV GALTKHVQAL DLSMRFR
Length

297

Mol. Wt

32.761 kDa

pI

5.0 (calculated)

Extinction coefficient

20,970 - 21,220 (calc based on 3 Y, 3 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed (By similarity)

UniProt:P30011

Domain

131..295

PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain

PMID:19920124[10]

Domain

41..129

PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=nadC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128102

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948869

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000374

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P30011

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11546

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11546

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948869

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001500

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1508

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Hughes, KT et al. (1993) The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase. J. Bacteriol. 175 479-86 PubMed
  6. ↑ Foster, JW & Moat, AG (1978) Mapping and characterization of the nad genes in Salmonella typhimurium LT-2. J. Bacteriol. 133 775-9 PubMed
  7. ↑ 7.0 7.1 7.2 Bhatia, R & Calvo, KC (1996) The sequencing expression, purification, and steady-state kinetic analysis of quinolinate phosphoribosyl transferase from Escherichia coli. Arch. Biochem. Biophys. 325 270-8 PubMed
  8. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ 10.0 10.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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