murA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MurA

Synonyms

UDP-N-acetylglucosamine 1-carboxyvinyltransferase[1], B3189[2][1], MurZ[2][1], MrbA[2][1], MurA[2][1] , ECK3178, JW3156, mrbA, murZ, b3189

Product description

UDP-N-acetylglucosamine enoylpyruvyl transferase; fosfomycin resistance[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00111

C

Seeded from EcoCyc (v14.0)

complete

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

PMID:1512209[4]

IDA: Inferred from Direct Assay

F

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

PMID:8075064[5]

IDA: Inferred from Direct Assay

F

PMID:7608103[6] states MurZ is MurA

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0007047

cellular cell wall organization

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0961

P

Seeded from EcoCyc (v14.0)

complete

GO:0007049

cell cycle

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded from EcoCyc (v14.0)

complete

GO:0008360

regulation of cell shape

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0133

P

Seeded from EcoCyc (v14.0)

complete

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00111

F

Seeded from EcoCyc (v14.0)

complete

GO:0008760

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.5.1.7

F

Seeded from EcoCyc (v14.0)

complete

GO:0009252

peptidoglycan biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00111

P

Seeded from EcoCyc (v14.0)

complete

GO:0009252

peptidoglycan biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0573

P

Seeded from EcoCyc (v14.0)

complete

GO:0019277

UDP-N-acetylgalactosamine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005750

P

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0132

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

prsA

PMID:15690043[7]

Experiment(s):EBI-888887

Protein

ftsI

PMID:15690043[7]

Experiment(s):EBI-888887

Protein

tufA

PMID:15690043[7]

Experiment(s):EBI-888887

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rpsJ

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

yhgF

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

wzc

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

degQ

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rapA

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

pepB

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rplD

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rplK

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rplL

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

rplM

PMID:15690043[7]

Experiment(s):EBI-894012

Protein

umuC

PMID:16606699[8]

Experiment(s):EBI-1145112

Protein

glnE

PMID:16606699[8]

Experiment(s):EBI-1145112

Protein

nadE

PMID:16606699[8]

Experiment(s):EBI-1145112

Protein

matC

PMID:16606699[8]

Experiment(s):EBI-1145112

Protein

uvrA

PMID:16606699[8]

Experiment(s):EBI-1145112

Protein

rapA

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

dnaN

PMID:19402753[9]

MALDI(Z-score):36.388166

Protein

yhgF

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

prs

PMID:19402753[9]

MALDI(Z-score):33.865689

Protein

degQ

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

wzc

PMID:19402753[9]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MDKFRVQGPT KLQGEVTISG AKNAALPILF AALLAEEPVE IQNVPKLKDV DTSMKLLSQL
GAKVERNGSV HIDARDVNVF CAPYDLVKTM RASIWALGPL VARFGQGQVS LPGGCTIGAR
PVDLHISGLE QLGATIKLEE GYVKASVDGR LKGAHIVMDK VSVGATVTIM CAATLAEGTT
IIENAAREPE IVDTANFLIT LGAKISGQGT DRIVIEGVER LGGGVYRVLP DRIETGTFLV
AAAISRGKII CRNAQPDTLD AVLAKLRDAG ADIEVGEDWI SLDMHGKRPK AVNVRTAPHP
AFPTDMQAQF TLLNLVAEGT GFITETVFEN RFMHVPELSR MGAHAEIESN TVICHGVEKL
SGAQVMATDL RASASLVLAG CIAEGTTVVD RIYHIDRGYE RIEDKLRALG ANIERVKGE
Length

419

Mol. Wt

44.817 kDa

pI

6.1 (calculated)

Extinction coefficient

18,450 - 19,200 (calc based on 5 Y, 2 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

6..406

PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=murA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131079

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947703

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010479

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A749

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11358

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11358

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947703

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001327

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1333

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ Marquardt, JL et al. (1992) Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase. J. Bacteriol. 174 5748-52 PubMed
  5. ↑ Brown, ED et al. (1994) Detection and characterization of a phospholactoyl-enzyme adduct in the reaction catalyzed by UDP-N-acetylglucosamine enolpyruvoyl transferase, MurZ. Biochemistry 33 10638-45 PubMed
  6. ↑ Brown, ED et al. (1995) MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. J. Bacteriol. 177 4194-7 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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